CY1111495T1 - Νεα παραγωγα του 3-φαινυλο-προπανοϊκου οξεος, ενεργοποιητες των υποδοχεων τυπου ppar, μεθοδος παρασκευης τους και χρηση αυτων σε κοσμητικες ή φαρμακευτικες συνθεσεις - Google Patents

Νεα παραγωγα του 3-φαινυλο-προπανοϊκου οξεος, ενεργοποιητες των υποδοχεων τυπου ppar, μεθοδος παρασκευης τους και χρηση αυτων σε κοσμητικες ή φαρμακευτικες συνθεσεις

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Publication number
CY1111495T1
CY1111495T1 CY20111100095T CY111100095T CY1111495T1 CY 1111495 T1 CY1111495 T1 CY 1111495T1 CY 20111100095 T CY20111100095 T CY 20111100095T CY 111100095 T CY111100095 T CY 111100095T CY 1111495 T1 CY1111495 T1 CY 1111495T1
Authority
CY
Cyprus
Prior art keywords
preparation
phenyl
receptor activators
ppar receptor
propanic acid
Prior art date
Application number
CY20111100095T
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English (en)
Inventor
Jean-Guy Boiteau
Laurence Clary
Jean-Claude Pascal
Véronique Parnet
Original Assignee
Galderma Research & Development
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Publication date
Application filed by Galderma Research & Development filed Critical Galderma Research & Development
Publication of CY1111495T1 publication Critical patent/CY1111495T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/08—Antiseborrheics
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07C233/00—Carboxylic acid amides
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    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
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    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/35—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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    • C07C2601/14—The ring being saturated

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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

Η ευρεσιτεχνία αναφέρεται σε νέα παράγωγα του 3-φαινυλο-προπανοϊκού οξέος που ανταποκρίνονται στον κατωτέρω γενικό τύπο (I) καθώς και σε μέθοδο παρασκευής τους, και στην χρήση τους σε φαρμακευτικές συνθέσεις προοριζόμενες για χρήση στην ιατρική ή στην κτηνιατρική (στην δερματολογία, καθώς και στον τομέα των καρδιοαγγειακών νόσων, των άνοσων ασθενειών και/ή των νόσων που συνδέονται με τον μεταβολισμό των λιπιδίων), ή ακόμη σε κοσμητικές συνθέσεις.
CY20111100095T 2007-06-05 2011-01-27 Νεα παραγωγα του 3-φαινυλο-προπανοϊκου οξεος, ενεργοποιητες των υποδοχεων τυπου ppar, μεθοδος παρασκευης τους και χρηση αυτων σε κοσμητικες ή φαρμακευτικες συνθεσεις CY1111495T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0755476A FR2917084B1 (fr) 2007-06-05 2007-06-05 Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
EP08805936A EP2155662B1 (fr) 2007-06-05 2008-06-04 Nouveaux derives d'acide 3-phenyl propanoique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques

Publications (1)

Publication Number Publication Date
CY1111495T1 true CY1111495T1 (el) 2015-08-05

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CY20111100095T CY1111495T1 (el) 2007-06-05 2011-01-27 Νεα παραγωγα του 3-φαινυλο-προπανοϊκου οξεος, ενεργοποιητες των υποδοχεων τυπου ppar, μεθοδος παρασκευης τους και χρηση αυτων σε κοσμητικες ή φαρμακευτικες συνθεσεις

Country Status (21)

Country Link
US (1) US7879907B2 (el)
EP (1) EP2155662B1 (el)
JP (1) JP2010529098A (el)
KR (1) KR20100028548A (el)
CN (1) CN101679216A (el)
AR (1) AR068974A1 (el)
AT (1) ATE490234T1 (el)
AU (1) AU2008263668A1 (el)
CA (1) CA2688239A1 (el)
CY (1) CY1111495T1 (el)
DE (1) DE602008003800D1 (el)
DK (1) DK2155662T3 (el)
ES (1) ES2357183T3 (el)
FR (1) FR2917084B1 (el)
HR (1) HRP20110133T1 (el)
MX (1) MX2009012841A (el)
PL (1) PL2155662T3 (el)
PT (1) PT2155662E (el)
RU (1) RU2009148335A (el)
SI (1) SI2155662T1 (el)
WO (1) WO2008152333A2 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2423793T3 (es) 2008-05-26 2013-09-24 Genfit Compuestos agonistas de PPAR, preparación y usos para el tratamiento de la diabetes y/o dislipidemias
FR2984730A1 (fr) * 2011-12-22 2013-06-28 Diverchim Nouvelles compositions cosmetiques anti-age et depigmentantes
CN103965048B (zh) * 2014-05-06 2016-02-17 西北农林科技大学 反式肉桂酸酯类化合物及其合成方法和应用

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FR2653119B1 (fr) * 1989-10-18 1994-08-05 Lipha Nouveaux aryloxy alcoyl benzenes, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
AU8750298A (en) * 1997-08-28 1999-03-22 Ono Pharmaceutical Co. Ltd. Peroxisome proliferator-activated receptor controllers
MA26634A1 (fr) * 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE9904421D0 (sv) * 1999-12-03 1999-12-03 Astra Ab New compounds
FR2812876B1 (fr) * 2000-08-08 2002-09-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
JP4529119B2 (ja) * 2001-08-09 2010-08-25 小野薬品工業株式会社 カルボン酸誘導体化合物およびその化合物を有効成分として含有する薬剤
FR2833949B1 (fr) * 2001-12-21 2005-08-05 Galderma Res & Dev NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
KR101106631B1 (ko) * 2003-02-13 2012-01-20 웰스태트 테러퓨틱스 코포레이션 대사 질환의 치료용 화합물
US7244763B2 (en) * 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
WO2005016862A1 (en) * 2003-08-14 2005-02-24 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivative and use thereof
WO2005019151A1 (en) * 2003-08-20 2005-03-03 Eli Lilly And Company Ppar modulators
JPWO2006057448A1 (ja) * 2004-11-26 2008-06-05 武田薬品工業株式会社 アリールアルカン酸誘導体
AU2006287521A1 (en) * 2005-09-07 2007-03-15 Plexxikon, Inc. PPARactive compounds
FR2892412B1 (fr) * 2005-10-26 2008-05-16 Galderma Res & Dev Composes biaromatiques modulateurs des ppars
JP5243696B2 (ja) * 2006-03-17 2013-07-24 田辺三菱製薬株式会社 ベンゼン誘導体
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations

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ATE490234T1 (de) 2010-12-15
ES2357183T3 (es) 2011-04-19
AU2008263668A1 (en) 2008-12-18
FR2917084B1 (fr) 2009-07-17
WO2008152333A3 (fr) 2009-02-19
EP2155662B1 (fr) 2010-12-01
FR2917084A1 (fr) 2008-12-12
DE602008003800D1 (de) 2011-01-13
US20100158843A1 (en) 2010-06-24
JP2010529098A (ja) 2010-08-26
PL2155662T3 (pl) 2011-04-29
SI2155662T1 (sl) 2011-04-29
US7879907B2 (en) 2011-02-01
WO2008152333A2 (fr) 2008-12-18
AR068974A1 (es) 2009-12-23
PT2155662E (pt) 2011-01-27
MX2009012841A (es) 2009-12-11
KR20100028548A (ko) 2010-03-12
CA2688239A1 (fr) 2008-12-18
DK2155662T3 (da) 2011-02-21
CN101679216A (zh) 2010-03-24
HRP20110133T1 (hr) 2011-04-30
EP2155662A2 (fr) 2010-02-24
WO2008152333A9 (fr) 2009-12-10
RU2009148335A (ru) 2011-07-20

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