CY1110113T1 - Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτων - Google Patents
Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτωνInfo
- Publication number
- CY1110113T1 CY1110113T1 CY20101100472T CY101100472T CY1110113T1 CY 1110113 T1 CY1110113 T1 CY 1110113T1 CY 20101100472 T CY20101100472 T CY 20101100472T CY 101100472 T CY101100472 T CY 101100472T CY 1110113 T1 CY1110113 T1 CY 1110113T1
- Authority
- CY
- Cyprus
- Prior art keywords
- phospholipid
- valproic acid
- mixes
- acid producers
- producers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/614,271 US6313106B1 (en) | 1995-06-07 | 2000-07-12 | Phospholipid derivatives of valproic acid and mixtures thereof |
| EP01949851A EP1315506B1 (en) | 2000-07-12 | 2001-07-10 | Phospholipid derivatives of valproic acid and mixtures thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110113T1 true CY1110113T1 (el) | 2015-01-14 |
Family
ID=24460534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100472T CY1110113T1 (el) | 2000-07-12 | 2010-05-28 | Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτων |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6313106B1 (https=) |
| EP (1) | EP1315506B1 (https=) |
| JP (1) | JP5140224B2 (https=) |
| KR (1) | KR100801213B1 (https=) |
| CN (1) | CN100536851C (https=) |
| AT (1) | ATE461697T1 (https=) |
| AU (2) | AU7096201A (https=) |
| BR (1) | BR0112337A (https=) |
| CA (1) | CA2415354C (https=) |
| CY (1) | CY1110113T1 (https=) |
| CZ (1) | CZ305745B6 (https=) |
| DE (1) | DE60141636D1 (https=) |
| DK (1) | DK1315506T3 (https=) |
| ES (1) | ES2343403T3 (https=) |
| HU (1) | HU229320B1 (https=) |
| IL (1) | IL153147A0 (https=) |
| MX (1) | MXPA03000326A (https=) |
| NZ (1) | NZ522788A (https=) |
| PT (1) | PT1315506E (https=) |
| WO (1) | WO2002007669A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313106B1 (en) * | 1995-06-07 | 2001-11-06 | D-Pharm Ltd. | Phospholipid derivatives of valproic acid and mixtures thereof |
| US6518311B2 (en) * | 1997-07-09 | 2003-02-11 | D-Pharm Ltd. | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
| US7582678B2 (en) | 1997-07-09 | 2009-09-01 | D-Pharm Limited | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
| CN1649600A (zh) | 2002-02-28 | 2005-08-03 | A&D生物科学公司 | 氟西汀及类似物的糖醛酰胺、苷和原酸酯苷及其应用 |
| WO2003079980A2 (en) * | 2002-03-19 | 2003-10-02 | A & D Bioscience, Inc. | Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof |
| WO2003086475A1 (en) * | 2002-04-12 | 2003-10-23 | A & D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof |
| CA2484891A1 (en) * | 2002-05-07 | 2003-11-20 | A & D Bioscience, Inc. | Conjugates comprising central nervous system active drug |
| US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
| US20050170063A1 (en) * | 2004-01-29 | 2005-08-04 | Lalit Chordia | Production of powder and viscous material |
| GB2460976B (en) * | 2005-03-24 | 2010-02-17 | John Marcell Davis | Methods of determining compounds useful in the treatment of bipolar disorder and methods of treating such disorders |
| WO2007028030A2 (en) * | 2005-09-02 | 2007-03-08 | Picobella, Llc | Oncogenic regulatory rnas for diagnostics and therapeutics |
| US7459280B2 (en) * | 2006-02-27 | 2008-12-02 | Picobella, Llc | Methods for diagnosing and treating kidney cancer |
| US20080267977A1 (en) * | 2007-04-26 | 2008-10-30 | Friedrich-Alexander University Of Erlangen-Nuremberg | Combined immunological agent and sensitizing agent for the treatment of cancer |
| KR200451744Y1 (ko) * | 2008-10-10 | 2011-01-10 | 이종희 | 휴대용 운동기구 |
| JP2015533114A (ja) * | 2012-05-08 | 2015-11-19 | セリックスビオ プライヴェート リミテッド | 神経疾患の治療のための組成物及び方法 |
| CN104230981B (zh) * | 2013-06-20 | 2016-05-18 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的制备方法 |
| PT3429580T (pt) * | 2016-03-16 | 2025-08-12 | Buzzelet Development And Technologies Ltd | Composição de canabinoides enriquecida em terpenos |
| CN108659038B (zh) * | 2017-03-31 | 2022-01-11 | 江苏恩华药业股份有限公司 | 1-硬脂酰-2-丙戊酰-sn-甘油-3-磷脂酰胆碱的多晶型物及制备方法 |
| CN108659037B (zh) * | 2017-03-31 | 2022-01-11 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的多晶型物及制备方法 |
| KR101864085B1 (ko) * | 2017-09-22 | 2018-06-01 | 동아대학교 산학협력단 | 발프로산 유도체, 이의 제조방법 및 이를 포함하는 항경련제 |
| CN110407867A (zh) * | 2018-04-28 | 2019-11-05 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的新晶型及其制备方法 |
| CN114344303B (zh) * | 2022-01-13 | 2023-05-09 | 江苏海洋大学 | 一种新型精神药物固体分散体及制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654370A (en) * | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
| US4988731A (en) | 1979-08-20 | 1991-01-29 | Abbott Laboratories | Sodium hydrogen divalproate oligomer |
| US5212326A (en) | 1979-08-20 | 1993-05-18 | Abbott Laboratories | Sodium hydrogen divalproate oligomer |
| US4558070A (en) | 1983-10-26 | 1985-12-10 | Abbott Laboratories | Acid salts of valproic acid |
| CA1260393A (en) * | 1984-10-16 | 1989-09-26 | Lajos Tarcsay | Liposomes of synthetic lipids |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| IT1201149B (it) | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche |
| ATE151467T1 (de) | 1987-11-30 | 1997-04-15 | Univ Iowa Res Found | Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene |
| DE3801587A1 (de) | 1988-01-21 | 1989-08-03 | Hoechst Ag | Neue aminosaeureglyceride, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung |
| CA2049028A1 (en) | 1989-03-07 | 1990-09-08 | Genentech, Inc. | Covalent conjugates of lipid and oligonucleotide |
| JPH03133987A (ja) | 1989-10-18 | 1991-06-07 | Kowa Yakuhin Kogyo Kk | ２‐マイトマイシンｃ‐スクシニル‐１，３‐ジパルミトイルグリセロールおよびその製造法 |
| WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| CH679856A5 (https=) | 1990-07-04 | 1992-04-30 | Lonza Ag | |
| US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
| AU668873B2 (en) | 1991-07-12 | 1996-05-23 | Chimerix, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
| US6015834A (en) | 1992-10-20 | 2000-01-18 | Toronto Neuroprotection Group | In vivo treatment of mammalian cells with a cell membrane permeant calcium buffer |
| IL105244A (en) | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
| US6413949B1 (en) | 1995-06-07 | 2002-07-02 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
| US6313106B1 (en) * | 1995-06-07 | 2001-11-06 | D-Pharm Ltd. | Phospholipid derivatives of valproic acid and mixtures thereof |
| IL121268A0 (en) * | 1997-07-09 | 1998-01-04 | Dpharm Ltd | Branched chain fatty acids their derivatives and use in the treatment of central nervous system disorders |
| KR100301803B1 (ko) | 1998-06-05 | 2001-09-22 | 김영환 | 박막트랜지스터 및 그의 제조방법 |
-
2000
- 2000-07-12 US US09/614,271 patent/US6313106B1/en not_active Expired - Lifetime
-
2001
- 2001-07-10 HU HU0302635A patent/HU229320B1/hu not_active IP Right Cessation
- 2001-07-10 PT PT01949851T patent/PT1315506E/pt unknown
- 2001-07-10 CN CNB018151736A patent/CN100536851C/zh not_active Expired - Lifetime
- 2001-07-10 CZ CZ2003-86A patent/CZ305745B6/cs not_active IP Right Cessation
- 2001-07-10 CA CA002415354A patent/CA2415354C/en not_active Expired - Fee Related
- 2001-07-10 AT AT01949851T patent/ATE461697T1/de active
- 2001-07-10 NZ NZ522788A patent/NZ522788A/en not_active IP Right Cessation
- 2001-07-10 AU AU7096201A patent/AU7096201A/xx active Pending
- 2001-07-10 DE DE60141636T patent/DE60141636D1/de not_active Expired - Lifetime
- 2001-07-10 BR BR0112337-8A patent/BR0112337A/pt not_active Application Discontinuation
- 2001-07-10 DK DK01949851.8T patent/DK1315506T3/da active
- 2001-07-10 EP EP01949851A patent/EP1315506B1/en not_active Expired - Lifetime
- 2001-07-10 MX MXPA03000326A patent/MXPA03000326A/es active IP Right Grant
- 2001-07-10 AU AU2001270962A patent/AU2001270962B8/en not_active Ceased
- 2001-07-10 WO PCT/IL2001/000629 patent/WO2002007669A2/en not_active Ceased
- 2001-07-10 JP JP2002513407A patent/JP5140224B2/ja not_active Expired - Fee Related
- 2001-07-10 ES ES01949851T patent/ES2343403T3/es not_active Expired - Lifetime
- 2001-07-10 KR KR1020027017319A patent/KR100801213B1/ko not_active Expired - Fee Related
- 2001-07-10 US US10/312,895 patent/US20040033987A1/en not_active Abandoned
- 2001-07-10 IL IL15314701A patent/IL153147A0/xx unknown
-
2010
- 2010-05-28 CY CY20101100472T patent/CY1110113T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60141636D1 (de) | 2010-05-06 |
| IL153147A0 (en) | 2003-06-24 |
| CA2415354A1 (en) | 2002-01-31 |
| PT1315506E (pt) | 2010-05-17 |
| AU2001270962B2 (en) | 2006-03-16 |
| DK1315506T3 (da) | 2010-05-31 |
| HUP0302635A2 (hu) | 2003-11-28 |
| BR0112337A (pt) | 2004-06-08 |
| US6313106B1 (en) | 2001-11-06 |
| JP2004509854A (ja) | 2004-04-02 |
| JP5140224B2 (ja) | 2013-02-06 |
| EP1315506A2 (en) | 2003-06-04 |
| AU7096201A (en) | 2002-02-05 |
| KR100801213B1 (ko) | 2008-02-05 |
| CN1774252A (zh) | 2006-05-17 |
| KR20030034099A (ko) | 2003-05-01 |
| CA2415354C (en) | 2009-09-29 |
| AU2001270962B8 (en) | 2006-08-10 |
| HUP0302635A3 (en) | 2007-06-28 |
| ATE461697T1 (de) | 2010-04-15 |
| WO2002007669A3 (en) | 2003-01-09 |
| NZ522788A (en) | 2005-04-29 |
| MXPA03000326A (es) | 2004-12-13 |
| WO2002007669A2 (en) | 2002-01-31 |
| EP1315506B1 (en) | 2010-03-24 |
| ES2343403T3 (es) | 2010-07-30 |
| CN100536851C (zh) | 2009-09-09 |
| CZ305745B6 (cs) | 2016-03-02 |
| US20040033987A1 (en) | 2004-02-19 |
| CZ200386A3 (cs) | 2003-06-18 |
| EP1315506A4 (en) | 2005-03-30 |
| HU229320B1 (en) | 2013-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1110113T1 (el) | Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτων | |
| CY1112055T1 (el) | Συνθεσεις και μεθοδοι για την διαγνωση και θεραπευτικη αγωγη ογκου πνευμονα | |
| PL360262A1 (pl) | Kompozycje polimerycznych micelli | |
| CY1107054T1 (el) | Ενωσεις διτοσυλικου αλατος κιναζολινης | |
| CY1105221T1 (el) | Ιατρικη χρηση θυρεοειδομιμητικων ενωσεων για την θepαπευτικη αγωγη της τριχοπτωσης και φαρμακευτικες συνθεσεις | |
| ATE365703T1 (de) | Substituierte 1,3-diphenylprop-2-en-1-on derivate,deren herstellung und anwendungen | |
| DE60204322D1 (de) | Stickstoffmonoxid bildende zusammensetzungen zur behandlung von nagelbettinfektionen | |
| ATE501722T1 (de) | Therapeutische behandlung androgenrezeptorbedingter leiden | |
| TR200000927T2 (tr) | Prostaglandin agonistleri ve kemik bozukluklarının tedavisi | |
| CY1108610T1 (el) | Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| DE69725825D1 (de) | 5-HT1F-Agonisten | |
| CY1109361T1 (el) | Υποκατεστημενες 4-αμινοκυκλοεξανολες | |
| DE60032795D1 (de) | Nordihydroguaiaretinsäurederivate zur behandlung von tumoren | |
| BR0201862A (pt) | Composições e métodos para tratar ou prevenir convulsões ou ataques apoplécticos | |
| MXPA03001643A (es) | Composiciones y metodos para el diagnostico y tratamiento de tumores. | |
| CY1107231T1 (el) | Υποκατεστημενα παραγωγα 4-αμινοκυκλοεξανολης | |
| ATE267816T1 (de) | Tan-1057 derivate | |
| AR024907A1 (es) | Uso de inhibidores de la produccion y/o accion de la il-18 y composiciones farmaceuticas formuladas con dichos inhibidores para el tratamiento demetastasis de tumores. | |
| TR200002203T2 (tr) | Lemfotoksin (LT) sentezlenme yolunun inhibitörleri kullanılarak foliküler lemfomaların tedavisi. | |
| TR200200278T2 (tr) | Kalsilitik bileşimler | |
| ID25478A (id) | Agonis 5-ht1f | |
| ATE261724T1 (de) | Antikonvulsive derivate zur behandlung von posttraumatischen stresserkrankungen | |
| BR0111785A (pt) | Composições e métodos para tratamento de candidìase | |
| ATE302009T1 (de) | Ubichinon qn zur behandlung von migräneschmerzen | |
| MXPA03001644A (es) | Composiciones y metodos para el diagnostico y tratamiento de tumor. |