CY1109355T1 - Πυριμιδινες υποκατεστημενες με αρυλιο και η χρηση αυτων - Google Patents

Πυριμιδινες υποκατεστημενες με αρυλιο και η χρηση αυτων

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Publication number
CY1109355T1
CY1109355T1 CY20091100941T CY091100941T CY1109355T1 CY 1109355 T1 CY1109355 T1 CY 1109355T1 CY 20091100941 T CY20091100941 T CY 20091100941T CY 091100941 T CY091100941 T CY 091100941T CY 1109355 T1 CY1109355 T1 CY 1109355T1
Authority
CY
Cyprus
Prior art keywords
treatment
prevention
formula
relates
compounds
Prior art date
Application number
CY20091100941T
Other languages
English (en)
Inventor
R Richard Goehring
Sam F Victory
Donald J Kyle
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of CY1109355T1 publication Critical patent/CY1109355T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η εφεύρεση σχετίζεται με μια μέθοδο αγωγής διαταραχών που επηρεάζονται από τον αποκλεισμό των διαύλων του ιόντος νατρίου η οποία χρησιμοποιεί νέες υποκατεστημένες με αρύλιο ενώσεις πυριμιδίνης του Τύπου (I): ή ένα φαρμακευτικώς αποδεκτό άλας, ή μια ένωση διαλύτη με αυτές, όπου τα A, R1, R2, R3 και R4 ορίζονται στην περιγραφή. Η εφεύρεση σχετίζεται επίσης με τη χρήση ενώσεων του τύπου I για την αγωγή βλάβης των νευρώνων που ακολουθεί την σφαιρική και την εστιακή ισχαιμία, για την αγωγή ή πρόληψη νευροεκφυλιστικών καταστάσεων όπως η πλαγία μυατροφική σκλήρυνση (ALS), και για την αγωγή, την πρόληψη ή την βελτίωση τόσο του οξέος όσο και του χρονίου πόνου, ως μέσων κατά των εμβοών, ως μέσων κατά των σπασμών, και ως αντιμανιακών κατασταλτικών, ως τοπικών αναισθητικών, ως αντιαρρυθμικών και για την αγωγή ή την πρόληψη της διαβητικής νευροπάθειας.
CY20091100941T 2002-03-13 2009-09-10 Πυριμιδινες υποκατεστημενες με αρυλιο και η χρηση αυτων CY1109355T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36354402P 2002-03-13 2002-03-13
EP03719019A EP1483247B1 (en) 2002-03-13 2003-03-13 Aryl substituted pyrimidines and the use thereof

Publications (1)

Publication Number Publication Date
CY1109355T1 true CY1109355T1 (el) 2014-07-02

Family

ID=27805282

Family Applications (1)

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CY20091100941T CY1109355T1 (el) 2002-03-13 2009-09-10 Πυριμιδινες υποκατεστημενες με αρυλιο και η χρηση αυτων

Country Status (27)

Country Link
US (1) US7229993B2 (el)
EP (1) EP1483247B1 (el)
JP (1) JP4473583B2 (el)
KR (1) KR20040099324A (el)
CN (1) CN1646500A (el)
AP (1) AP2004003152A0 (el)
AT (1) ATE434610T1 (el)
AU (1) AU2003223049A1 (el)
BR (1) BR0308451A (el)
CA (1) CA2479036A1 (el)
CO (1) CO5611139A2 (el)
CR (1) CR7526A (el)
CY (1) CY1109355T1 (el)
DE (1) DE60328087D1 (el)
DK (1) DK1483247T3 (el)
EA (1) EA200401120A1 (el)
EC (1) ECSP045360A (el)
ES (1) ES2328471T3 (el)
IL (1) IL163940A0 (el)
IS (1) IS7468A (el)
MA (1) MA27196A1 (el)
MX (1) MXPA04008901A (el)
NO (1) NO20044311L (el)
PT (1) PT1483247E (el)
SI (1) SI1483247T1 (el)
TN (1) TNSN04174A1 (el)
WO (1) WO2003076414A2 (el)

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US7229993B2 (en) 2007-06-12
BR0308451A (pt) 2005-01-11
WO2003076414A2 (en) 2003-09-18
CA2479036A1 (en) 2003-09-18
WO2003076414A3 (en) 2003-12-24
AU2003223049A1 (en) 2003-09-22
EA200401120A1 (ru) 2005-02-24
JP4473583B2 (ja) 2010-06-02
DE60328087D1 (de) 2009-08-06
CR7526A (es) 2008-08-12
EP1483247B1 (en) 2009-06-24
JP2005526069A (ja) 2005-09-02
MA27196A1 (fr) 2005-01-03
EP1483247A2 (en) 2004-12-08
ES2328471T3 (es) 2009-11-13
NO20044311L (no) 2004-12-10
TNSN04174A1 (en) 2007-03-12
MXPA04008901A (es) 2004-11-26
AP2004003152A0 (en) 2004-12-31
IL163940A0 (en) 2005-12-18
US20030236273A1 (en) 2003-12-25
KR20040099324A (ko) 2004-11-26
DK1483247T3 (da) 2009-08-17
ATE434610T1 (de) 2009-07-15
PT1483247E (pt) 2009-08-18
SI1483247T1 (sl) 2009-12-31
IS7468A (is) 2004-09-24
ECSP045360A (es) 2005-01-03
CO5611139A2 (es) 2006-02-28
CN1646500A (zh) 2005-07-27

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