CY1108829T1 - Ενεργοποιηση ace2 για θεραπεια καρδιακης, πνευμονικης και νεφρικης ασθενειας και υπερτασης - Google Patents
Ενεργοποιηση ace2 για θεραπεια καρδιακης, πνευμονικης και νεφρικης ασθενειας και υπερτασηςInfo
- Publication number
- CY1108829T1 CY1108829T1 CY20091100214T CY091100214T CY1108829T1 CY 1108829 T1 CY1108829 T1 CY 1108829T1 CY 20091100214 T CY20091100214 T CY 20091100214T CY 091100214 T CY091100214 T CY 091100214T CY 1108829 T1 CY1108829 T1 CY 1108829T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pulmonary
- cardiac
- disease
- renal disease
- ace2
- Prior art date
Links
- 102000053723 Angiotensin-converting enzyme 2 Human genes 0.000 title abstract 3
- 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 title abstract 3
- 208000019693 Lung disease Diseases 0.000 title abstract 3
- 208000017169 kidney disease Diseases 0.000 title abstract 3
- 208000020446 Cardiac disease Diseases 0.000 title 1
- 206010020772 Hypertension Diseases 0.000 title 1
- 230000004913 activation Effects 0.000 title 1
- 230000000747 cardiac effect Effects 0.000 title 1
- 208000019622 heart disease Diseases 0.000 title 1
- 230000002685 pulmonary effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2267/03—Animal model, e.g. for test or diseases
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Environmental Sciences (AREA)
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Abstract
Η εφεύρεση αφορά ενεργοποιητικές του ACE2 ενώσεις για την πρόληψη και θεραπεία καρδιαγγειακής ασθένειας, νεφρικής ασθένειας, πνευμονικής ασθένειας και υπέρτασης. Η εφεύρεση επίσης περιλαμβάνει μεθόδους διάγνωσης καρδιαγγειακής ασθένειας, νεφρικής ασθένειας, πνευμονικής ασθένειας και υπέρτασης με μέτρηση ACE2 έκφρασης ή ανάλυσης πολυμορφισμού νουκλεοτιδίων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38970902P | 2002-06-19 | 2002-06-19 | |
EP03729747A EP1515752B1 (en) | 2002-06-19 | 2003-06-19 | Ace2 activation for treatment of heart, lung and kidney disease and hypertension |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108829T1 true CY1108829T1 (el) | 2014-04-09 |
Family
ID=30000461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100214T CY1108829T1 (el) | 2002-06-19 | 2009-02-26 | Ενεργοποιηση ace2 για θεραπεια καρδιακης, πνευμονικης και νεφρικης ασθενειας και υπερτασης |
Country Status (14)
Country | Link |
---|---|
US (3) | US7794707B2 (el) |
EP (3) | EP1515752B1 (el) |
JP (1) | JP4598518B2 (el) |
CN (2) | CN101961493A (el) |
AT (1) | ATE415175T1 (el) |
AU (1) | AU2003240331B2 (el) |
CA (1) | CA2489873C (el) |
CY (1) | CY1108829T1 (el) |
DE (1) | DE60324925D1 (el) |
DK (2) | DK2332582T3 (el) |
ES (3) | ES2424971T3 (el) |
PT (2) | PT1515752E (el) |
SI (2) | SI1515752T1 (el) |
WO (1) | WO2004000367A1 (el) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2424971T3 (es) * | 2002-06-19 | 2013-10-10 | Apeiron Biologics Ag | Activación de ECA2 para el tratamiento de enfermedades cardíacas, pulmonares y renales e hipertensión |
EP1723962A1 (en) | 2005-05-19 | 2006-11-22 | IMBA-Institut für Molekulare Biotechnologie GmbH | Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries |
GB0511279D0 (en) * | 2005-06-02 | 2005-07-13 | Univ Warwick | Assay |
AU2007325761A1 (en) * | 2006-11-22 | 2008-06-05 | University Of Florida Research Foundation, Inc. | ACE2 activator compounds and methods of use thereof |
AT505262A1 (de) | 2007-06-12 | 2008-12-15 | Apeiron Biolog Forschungs Und | Rekombinantes ace2 polypeptid |
AT506258A1 (de) * | 2007-12-18 | 2009-07-15 | Apeiron Biolog Forschungs Und | Behandlung inflammatorischer krankheiten |
EP2077119A1 (de) * | 2007-12-21 | 2009-07-08 | Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H. | Behandlung von Fibrosen und Lebererkrankungen |
AT506632A1 (de) | 2008-04-09 | 2009-10-15 | Apeiron Biolog Forschungs Und | Behandlung von tumorerkrankungen |
CA2957211C (en) | 2013-10-18 | 2022-07-05 | Trustees Of The University Of Pennsylvania | Oral delivery of angiotensin converting enzyme 2 (ace2) or angiotensin-(1-7) bioencapsulated in plant cells |
EP3717077A1 (en) | 2017-11-29 | 2020-10-07 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation |
KR102592176B1 (ko) | 2018-01-05 | 2023-10-20 | 플레이틀렛 바이오제네시스, 인크. | 거핵구 생성을 위한 조성물 및 방법 |
CN108660205A (zh) * | 2018-07-04 | 2018-10-16 | 刘城 | 一种糖尿病遗传风险评估试剂盒及其运用 |
CN110577588B (zh) * | 2019-09-29 | 2020-12-29 | 苏州大学 | 一种凹耳蛙免疫调节肽及其应用 |
CN111087445B (zh) * | 2019-10-14 | 2021-08-24 | 浙江大学 | 一种用于ace2活性检测的质谱探针及其制备方法和应用 |
WO2021190980A1 (en) | 2020-03-22 | 2021-09-30 | Quadrucept Bio Limited | Multimers for viral strain evolution |
WO2021197501A1 (zh) * | 2020-04-02 | 2021-10-07 | 创观(苏州)生物科技有限公司 | 病毒不易感动物 |
US20240002935A1 (en) * | 2020-04-11 | 2024-01-04 | Geneticure Inc. | Genetic method for diagnosis and treatment of pre and post coronavirus infections |
WO2022008642A1 (en) | 2020-07-08 | 2022-01-13 | Apeiron Biologics Ag | Treatment of sars-cov-2 infection with a combination of targets |
JP7563940B2 (ja) * | 2020-10-22 | 2024-10-08 | シスメックス株式会社 | 呼吸器感染症に関する情報の取得方法、バイオマーカーの測定値のモニタリング方法、試薬キット、呼吸器感染症に関する情報の取得装置及びコンピュータプログラム |
EP4011387A1 (en) | 2020-12-11 | 2022-06-15 | IMBA-Institut für Molekulare Biotechnologie GmbH | Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2 |
WO2022184659A1 (en) | 2021-03-01 | 2022-09-09 | Quadrucept Bio Limited | Antibody domains & multimers |
WO2022207918A1 (en) | 2021-04-02 | 2022-10-06 | Apeiron Biologics Ag | COVID-19 Therapy |
CN118056013A (zh) * | 2021-08-31 | 2024-05-17 | 纽约大学 | 用于逐步转换抗生素抗性标记以进行整合(mSwAP-In)的组合物和方法 |
EP4147702A1 (en) | 2021-09-13 | 2023-03-15 | Medizinische Universität Graz | Novel combination of heparin and ace2 decoys for the treatment of covid-19 |
WO2023102156A1 (en) | 2021-12-03 | 2023-06-08 | Wisconsin Alumni Research Foundation | Mutant ace2 proteins and methods of using same |
WO2023144625A2 (en) * | 2022-01-27 | 2023-08-03 | The Chinese University Of Hong Kong | Enhanced hace2-based neutralizing agents against sars-cov-2 infection |
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AU4500200A (en) | 1999-04-30 | 2000-11-17 | Millennium Pharmaceuticals, Inc. | Ace-2 inhibiting compounds and methods of use thereof |
WO2001029040A2 (en) | 1999-10-21 | 2001-04-26 | Ciba Specialty Chemicals Holding Inc. | PROCESS FOR THE PREPARATION OF PYRIMIDO[5,4-g]PTERIDINE DERIVATIVES |
JP4520569B2 (ja) | 2000-02-18 | 2010-08-04 | 照彦 豊岡 | 拡張型心筋症の遺伝子治療剤 |
US6303830B1 (en) * | 2000-03-15 | 2001-10-16 | Union Carbide Chemicals & Plastics Technology Corporation | Metal-ligand complex catalyzed processes |
WO2002012471A2 (en) * | 2000-08-09 | 2002-02-14 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and uses therefor |
ES2424971T3 (es) * | 2002-06-19 | 2013-10-10 | Apeiron Biologics Ag | Activación de ECA2 para el tratamiento de enfermedades cardíacas, pulmonares y renales e hipertensión |
-
2003
- 2003-06-19 ES ES08019249T patent/ES2424971T3/es not_active Expired - Lifetime
- 2003-06-19 WO PCT/CA2003/000882 patent/WO2004000367A1/en active Application Filing
- 2003-06-19 AU AU2003240331A patent/AU2003240331B2/en not_active Expired
- 2003-06-19 ES ES10178474.2T patent/ES2443305T3/es not_active Expired - Lifetime
- 2003-06-19 ES ES03729747T patent/ES2318137T3/es not_active Expired - Lifetime
- 2003-06-19 AT AT03729747T patent/ATE415175T1/de active
- 2003-06-19 EP EP03729747A patent/EP1515752B1/en not_active Expired - Lifetime
- 2003-06-19 CA CA2489873A patent/CA2489873C/en not_active Expired - Lifetime
- 2003-06-19 PT PT03729747T patent/PT1515752E/pt unknown
- 2003-06-19 EP EP08019249.5A patent/EP2047867B1/en not_active Expired - Lifetime
- 2003-06-19 EP EP10178474.2A patent/EP2332582B1/en not_active Expired - Lifetime
- 2003-06-19 JP JP2004514460A patent/JP4598518B2/ja not_active Expired - Lifetime
- 2003-06-19 CN CN2010101656787A patent/CN101961493A/zh active Pending
- 2003-06-19 SI SI200331524T patent/SI1515752T1/sl unknown
- 2003-06-19 DK DK10178474.2T patent/DK2332582T3/da active
- 2003-06-19 DE DE60324925T patent/DE60324925D1/de not_active Expired - Lifetime
- 2003-06-19 US US10/518,599 patent/US7794707B2/en not_active Expired - Lifetime
- 2003-06-19 SI SI200332334T patent/SI2332582T1/sl unknown
- 2003-06-19 CN CN038183595A patent/CN1671425B/zh not_active Expired - Lifetime
- 2003-06-19 DK DK03729747T patent/DK1515752T3/da active
- 2003-06-19 PT PT101784742T patent/PT2332582E/pt unknown
-
2009
- 2009-02-26 CY CY20091100214T patent/CY1108829T1/el unknown
-
2010
- 2010-07-06 US US12/830,782 patent/US8211426B2/en not_active Expired - Fee Related
-
2012
- 2012-05-31 US US13/484,585 patent/US8802084B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP4598518B2 (ja) | 2010-12-15 |
CA2489873A1 (en) | 2003-12-31 |
CN1671425B (zh) | 2013-07-10 |
US7794707B2 (en) | 2010-09-14 |
PT1515752E (pt) | 2009-03-05 |
DE60324925D1 (de) | 2009-01-08 |
EP1515752A1 (en) | 2005-03-23 |
AU2003240331B2 (en) | 2008-08-21 |
WO2004000367A1 (en) | 2003-12-31 |
EP2332582A1 (en) | 2011-06-15 |
US20050251873A1 (en) | 2005-11-10 |
US20120251520A1 (en) | 2012-10-04 |
JP2006504637A (ja) | 2006-02-09 |
CA2489873C (en) | 2016-08-09 |
US8802084B2 (en) | 2014-08-12 |
EP2332582B1 (en) | 2013-10-30 |
EP2047867A1 (en) | 2009-04-15 |
DK2332582T3 (da) | 2014-01-20 |
AU2003240331A1 (en) | 2004-01-06 |
ATE415175T1 (de) | 2008-12-15 |
SI1515752T1 (sl) | 2009-06-30 |
ES2424971T3 (es) | 2013-10-10 |
PT2332582E (pt) | 2014-01-28 |
CN1671425A (zh) | 2005-09-21 |
EP1515752B1 (en) | 2008-11-26 |
SI2332582T1 (sl) | 2014-03-31 |
US8211426B2 (en) | 2012-07-03 |
US20100311822A1 (en) | 2010-12-09 |
DK1515752T3 (da) | 2009-03-23 |
ES2318137T3 (es) | 2009-05-01 |
EP2047867B1 (en) | 2013-05-22 |
ES2443305T3 (es) | 2014-02-18 |
CN101961493A (zh) | 2011-02-02 |
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