CY1108330T1 - Ανθρωπινο κυκλοφορητικο ανασταλτικο για ιο πεπτιδιο (virip) και η χρησιμοποιηση του - Google Patents

Ανθρωπινο κυκλοφορητικο ανασταλτικο για ιο πεπτιδιο (virip) και η χρησιμοποιηση του

Info

Publication number
CY1108330T1
CY1108330T1 CY20081100976T CY081100976T CY1108330T1 CY 1108330 T1 CY1108330 T1 CY 1108330T1 CY 20081100976 T CY20081100976 T CY 20081100976T CY 081100976 T CY081100976 T CY 081100976T CY 1108330 T1 CY1108330 T1 CY 1108330T1
Authority
CY
Cyprus
Prior art keywords
virip
virus
activity
antagonist
inhibitor
Prior art date
Application number
CY20081100976T
Other languages
English (en)
Inventor
Frank Kirchhoff
Jan Münch
Ludger Ständker
Wolf-Georg Forssmann
Knut Adermann
Original Assignee
Ipf Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999153732 external-priority patent/DE19953732A1/de
Priority claimed from DE2000123665 external-priority patent/DE10023665A1/de
Application filed by Ipf Pharmaceuticals Gmbh filed Critical Ipf Pharmaceuticals Gmbh
Publication of CY1108330T1 publication Critical patent/CY1108330T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Πεπτίδιο με την παρακάτω ακολουθία αμινοξέων: Z1-LEAIPMSIPPEVKFNKPFVF-Z2 (VIRIP), καθώς και τα βιολογικά ενεργά θραύσματα και/ή οι εκδοχές και/ή τα παράγωγα του, ειδικότερα αμιδιωμένα, ακετυλιωμένα, σουλφουρωμένα, τροποποιημένα με πολυαιθυλενογλυκόλη (PEG), φωσφορυλιωμένα και/ή γλυκοζυλιωμένα παράγωγα, καθώς και τα παραγόμενα με πολλαπλή σύνθεση πεπτίδια, το οποία έχουν την βιολογική δραστικότητα του VIRIP, σε αυτά Ζ1, Ζ2 αντιπροσωπεύουν ανεξάρτητα μεταξύ τους έναν αριθμό από 0 έως 10 ρίζες αμινοξέων, και εφόσον Ζ1 ή Ζ2 = σημαίνουν 0 ρίζες αμινοξέων, τότε Ζ1 = Η και/ή Ζ2 = COOH.
CY20081100976T 1999-11-08 2008-09-10 Ανθρωπινο κυκλοφορητικο ανασταλτικο για ιο πεπτιδιο (virip) και η χρησιμοποιηση του CY1108330T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999153732 DE19953732A1 (de) 1999-11-08 1999-11-08 Humanes zirkulierendes Virus inhibierendes Peptid (VIRIP) und seine Verwendung
DE2000123665 DE10023665A1 (de) 2000-05-16 2000-05-16 Humanes zirkulierendes Virus inhibierendes Peptid (VIRIP) und seine Verwendung
EP00987221A EP1228203B1 (de) 1999-11-08 2000-11-08 Humanes zirkulierendes virus inhibierendes peptid (virip) und seine verwendung

Publications (1)

Publication Number Publication Date
CY1108330T1 true CY1108330T1 (el) 2014-02-12

Family

ID=26005679

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100976T CY1108330T1 (el) 1999-11-08 2008-09-10 Ανθρωπινο κυκλοφορητικο ανασταλτικο για ιο πεπτιδιο (virip) και η χρησιμοποιηση του

Country Status (13)

Country Link
US (1) US7037896B1 (el)
EP (2) EP1959013B1 (el)
JP (1) JP4813720B2 (el)
AT (1) ATE398674T1 (el)
AU (1) AU2354801A (el)
CA (1) CA2390652C (el)
CY (1) CY1108330T1 (el)
DE (1) DE50015216D1 (el)
DK (1) DK1228203T3 (el)
ES (1) ES2307549T3 (el)
HK (1) HK1124083A1 (el)
PT (1) PT1228203E (el)
WO (1) WO2001034640A2 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100144630A1 (en) * 1999-03-05 2010-06-10 Leland Shapiro Compositions, methods and uses for inhibition and/or treatment of influenza infection
US20100210528A1 (en) * 1999-03-05 2010-08-19 Leland Shapiro Compositions, methods and uses for inhibition and/or treatment of influenza infection
JP4505336B2 (ja) * 2002-12-19 2010-07-21 イーペーエフ ファルマシューティカルス ゲゼルシャフト ミット ベシュレンクテル ハフツング ペプチドおよびｈｉｖ感染の治療のためのその使用
BRPI0511005A (pt) * 2004-06-18 2007-11-20 Ipf Pharmaceuticals Gmbh peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv
AU2007207544A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
CN102507824B (zh) * 2011-11-01 2013-10-09 北京三元基因工程有限公司 聚乙二醇修饰蛋白质的修饰位点分析方法
EP3473650A1 (en) * 2017-10-18 2019-04-24 Universitätsklinikum Jena Antibody for the specific detection of caap47/48 fragments
US20230235022A1 (en) * 2020-01-16 2023-07-27 Case Western Reserve University Neutrophil elastase binding peptides and compositions thereof
US20230398177A1 (en) * 2020-10-22 2023-12-14 The University Of Hong Kong Compositions of anti-viral peptides and/or compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3482840D1 (de) 1983-01-21 1990-09-06 Transgene Sa Expressionsvektoren und deren verwendung zur herstellung eines proteins mit menschlicher alpha-antitrypsin-aktivitaet.
US5827662A (en) 1989-06-23 1998-10-27 The Trustees Of The University Of Pennsylvania Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
JPH06509327A (ja) 1991-04-18 1994-10-20 ザ　ユー　エー　ビー　リサーチ　ファンデーション エラスターゼ抑制のための組成とその方法
US5175253A (en) 1991-04-24 1992-12-29 Washington University Binding peptides
US5972901A (en) * 1994-03-23 1999-10-26 Case Western Reserve University Serpin enzyme complex receptor--mediated gene transfer
CA2391348A1 (en) 1999-07-29 2001-02-08 Assem Ziady Enhanced delivery via serpin enzyme complex receptor

Also Published As

Publication number Publication date
ATE398674T1 (de) 2008-07-15
DE50015216D1 (de) 2008-07-31
CA2390652C (en) 2011-03-29
EP1228203A2 (de) 2002-08-07
US7037896B1 (en) 2006-05-02
EP1959013B1 (de) 2014-04-23
WO2001034640A3 (de) 2001-11-01
AU2354801A (en) 2001-06-06
JP2003516729A (ja) 2003-05-20
DK1228203T3 (da) 2008-10-20
JP4813720B2 (ja) 2011-11-09
HK1124083A1 (en) 2009-07-03
CA2390652A1 (en) 2001-05-17
EP1959013A1 (de) 2008-08-20
EP1228203B1 (de) 2008-06-18
PT1228203E (pt) 2008-09-03
WO2001034640A2 (de) 2001-05-17
ES2307549T3 (es) 2008-12-01

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