CY1107276T1 - Μεταλλαγμενη ολοτοξινη χολερας ως ενα ανοσοενισχυτικο - Google Patents

Μεταλλαγμενη ολοτοξινη χολερας ως ενα ανοσοενισχυτικο

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Publication number
CY1107276T1
CY1107276T1 CY20081100125T CY081100125T CY1107276T1 CY 1107276 T1 CY1107276 T1 CY 1107276T1 CY 20081100125 T CY20081100125 T CY 20081100125T CY 081100125 T CY081100125 T CY 081100125T CY 1107276 T1 CY1107276 T1 CY 1107276T1
Authority
CY
Cyprus
Prior art keywords
amino acid
cholera
allotoxin
chlora
immune
Prior art date
Application number
CY20081100125T
Other languages
English (en)
Inventor
Randall K Holmes
Michael G Jobling
John H Eldridge
Bruce A Green
Gerald E Hancock
Joel A Peek
Original Assignee
Wyeth Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings Corporation filed Critical Wyeth Holdings Corporation
Publication of CY1107276T1 publication Critical patent/CY1107276T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
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    • A61K2039/53—DNA (RNA) vaccination
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    • A61K2039/541—Mucosal route
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2720/12311—Rotavirus, e.g. rotavirus A
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Μια μεταλλαγμένη ολοτοξίνη χολέρας η οποία παρουσιάζει μια σημειακή μετάλλαξη στο αμινοξύ 29 της Α υπομονάδας, όπου το κατάλοιπο γλουταμινικού οξέος αντικαθίσταται από ένα αμινοξύ διαφορετικό του ασπαρτικού οξέος, είναι χρήσιμη ως ένα ανοσοενισχυτικό σε μια αντιγονική σύνθεση για ενίσχυση της άνοσης απόκρισης σε έναν σπονδυλωτό ξενιστή προς ένα επιλεγμένο αντιγόνο από ένα παθογόνο βακτήριο, ιό, μύκητα ή παράσιτο. Σε μια συγκεκριμένη υλοποίηση, το αμινοξύ 29 είναι ιστιδίνη. Η μεταλλαγμένη ολοτοξίνη χολέρας μπορεί να περιέχει μία επιπρόσθετη μετάλλαξη στην Α υπομονάδα σε μια θέση διαφορετική από αυτή του αμινοξέος 29. Η αντιγονική σύνθεση μπορεί να περιλαμβάνει ένα δεύτερο ανοσοενισχυτικό εκτός από την μεταλλαγμένη ολοτοξίνη χολέρας.
CY20081100125T 1998-09-30 2008-02-01 Μεταλλαγμενη ολοτοξινη χολερας ως ενα ανοσοενισχυτικο CY1107276T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10243098P 1998-09-30 1998-09-30
EP99951639A EP1117435B1 (en) 1998-09-30 1999-09-30 Mutant cholera holotoxin as an adjuvant

Publications (1)

Publication Number Publication Date
CY1107276T1 true CY1107276T1 (el) 2012-11-21

Family

ID=22289805

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100125T CY1107276T1 (el) 1998-09-30 2008-02-01 Μεταλλαγμενη ολοτοξινη χολερας ως ενα ανοσοενισχυτικο

Country Status (16)

Country Link
EP (1) EP1117435B1 (el)
JP (1) JP4673974B2 (el)
KR (1) KR100659803B1 (el)
CN (1) CN1197618C (el)
AT (1) ATE378066T1 (el)
AU (1) AU770333B2 (el)
BR (1) BR9914160A (el)
CA (1) CA2344740C (el)
CY (1) CY1107276T1 (el)
DE (1) DE69937571T2 (el)
DK (1) DK1117435T3 (el)
ES (1) ES2293735T3 (el)
IL (2) IL142231A0 (el)
MX (1) MXPA01003228A (el)
PT (1) PT1117435E (el)
WO (1) WO2000018434A1 (el)

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DE69937571T2 (de) 2008-09-04
ATE378066T1 (de) 2007-11-15
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DK1117435T3 (da) 2008-03-17
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WO2000018434A1 (en) 2000-04-06
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KR100659803B1 (ko) 2006-12-19
IL142231A (en) 2010-05-31
AU770333B2 (en) 2004-02-19
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CN1320043A (zh) 2001-10-31
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