CY1106582T1 - Αντικαρκινικες συνθεσεις που περιεχουν παραγωγα ταξανης - Google Patents
Αντικαρκινικες συνθεσεις που περιεχουν παραγωγα ταξανηςInfo
- Publication number
- CY1106582T1 CY1106582T1 CY20071100643T CY071100643T CY1106582T1 CY 1106582 T1 CY1106582 T1 CY 1106582T1 CY 20071100643 T CY20071100643 T CY 20071100643T CY 071100643 T CY071100643 T CY 071100643T CY 1106582 T1 CY1106582 T1 CY 1106582T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compositions containing
- taxane derivatives
- containing taxane
- cancer compositions
- inhibitor
- Prior art date
Links
- 230000001093 anti-cancer Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000340 anti-metabolite Effects 0.000 abstract 1
- 229940100197 antimetabolite Drugs 0.000 abstract 1
- 239000002256 antimetabolite Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000008512 biological response Effects 0.000 abstract 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 230000000394 mitotic effect Effects 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- 229940063683 taxotere Drugs 0.000 abstract 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 abstract 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Στο παρόν κείμενο περιγράφονται ένα φαρμακευτικό σκεύασμα το οποίο αποτελείται από ακετοκυκλοπροπυλ taxotere ή κάποιο παράγωγο αυτού, και τουλάχιστον ένας εκ των αλκυλιωτικών παραγόντων, ένας αντιμεταβολίτης, ένας αναστολέας της μιτωτικής ατράκτου, μια επιδοφυλλοτοξίνη, ένα αντιβιοτικό, ένα ένζυμο, ένας αναστολέας τοποϊσομεράσης, ένα σύμπλεγμα συντονισμού λευκόχρυσου, ένας μετατροπέας βιολογικής αντίδρασης ή ένας αναστολέας παράγοντα ανάπτυξης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/813,018 US6441026B1 (en) | 1993-11-08 | 2001-03-21 | Antitumor compositions containing taxane derivatives |
PCT/IB2002/000853 WO2002074289A2 (en) | 2001-03-21 | 2002-03-21 | Antitumor compositions containing taxane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106582T1 true CY1106582T1 (el) | 2012-01-25 |
Family
ID=25211230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100643T CY1106582T1 (el) | 2001-03-21 | 2007-05-10 | Αντικαρκινικες συνθεσεις που περιεχουν παραγωγα ταξανης |
Country Status (19)
Country | Link |
---|---|
US (1) | US6441026B1 (el) |
EP (1) | EP1478355B1 (el) |
JP (1) | JP4467885B2 (el) |
CN (2) | CN1536995A (el) |
AT (1) | ATE355837T1 (el) |
AU (1) | AU2002244877B2 (el) |
BR (1) | BR0208274A (el) |
CA (1) | CA2440160C (el) |
CY (1) | CY1106582T1 (el) |
DE (1) | DE60218751T2 (el) |
DK (1) | DK1478355T3 (el) |
EA (1) | EA006878B1 (el) |
ES (1) | ES2282400T3 (el) |
HU (1) | HUP0500478A2 (el) |
IL (1) | IL157992A (el) |
MX (1) | MXPA03008539A (el) |
PT (1) | PT1478355E (el) |
SI (1) | SI1478355T1 (el) |
WO (2) | WO2002074232A2 (el) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
FR2698871B1 (fr) | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
BRPI0207961B8 (pt) * | 2001-03-14 | 2021-05-25 | Bristol Myers Squibb Co | uso de análogos de epotilona e capecitabina para fabricar medicamento para tratar tumores cancerosos sólidos e kit compreendendo os referidos compostos. |
ITRM20020191A1 (it) * | 2002-04-08 | 2003-10-08 | Sigma Tau Ind Farmaceuti | Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie tumorali associate ad una alterata att |
NZ535992A (en) * | 2002-05-17 | 2008-11-28 | Aventis Pharma Sa | Use of docetaxel/doxorubicin/cyclophosphamide in adjuvant therapy of breast and ovarian cancer |
WO2004035034A2 (en) * | 2002-10-16 | 2004-04-29 | Ilex Products, Inc. | Clofarabine and taxane chemotherapy combination |
ITMI20030317A1 (it) * | 2003-02-21 | 2004-08-22 | Pharmacia Italia Spa | Terapia combinata comprendente un derivato dell'indolopirrolocarbazolo ed un altro agente antitumorale. |
WO2004103344A1 (en) * | 2003-05-20 | 2004-12-02 | Aronex Pharmaceuticals, Inc. | Combination chemotherapy comprising a liposomal platinum complex |
CN100340296C (zh) * | 2005-02-03 | 2007-10-03 | 山东蓝金生物工程有限公司 | 一种抗癌体内植入剂 |
DK3248600T3 (da) * | 2005-02-18 | 2020-07-06 | Abraxis Bioscience Llc | Kombinationer og måder til administration af terapeutiske stoffer og kombinationsterapi |
US8735394B2 (en) * | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
DK2206736T3 (da) * | 2005-12-05 | 2012-04-23 | Nitto Denko Corp | Polyglutamat-aminosyre-konjugater og fremgangsmåder |
EP1913958B1 (en) * | 2006-08-03 | 2009-12-23 | Sanofi-Aventis | Antitumor compositions containing acetylcyclopropyl docetaxel and trastuzumab |
US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
WO2008124735A2 (en) * | 2007-04-10 | 2008-10-16 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
ES2430380T3 (es) | 2007-05-09 | 2013-11-20 | Nitto Denko Corporation | Composiciones que incluyen un compuesto hidrófobo y un conjugado de poliaminoácido |
DK2155254T3 (da) * | 2007-05-09 | 2013-03-04 | Nitto Denko Corp | Med platinlægemidler konjugerede polymere |
CN101707869A (zh) * | 2007-05-09 | 2010-05-12 | 日东电工株式会社 | 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 |
MX2010009670A (es) * | 2008-03-06 | 2010-09-22 | Nitto Denko Corp | Conjugados de paclitaxel polimericos y metodos para tratamiento de cancer. |
CN105147613A (zh) | 2010-03-29 | 2015-12-16 | 阿布拉科斯生物科学有限公司 | 增强药物递送和治疗剂有效性的方法 |
SG10201906075VA (en) | 2010-03-29 | 2019-08-27 | Abraxis Bioscience Llc | Methods of treating cancer |
WO2011153010A1 (en) | 2010-06-04 | 2011-12-08 | Abraxis Biosciences, Llc | Methods of treatment of pancreatic cancer |
AU2011325982C1 (en) * | 2010-11-12 | 2015-08-20 | Endocyte, Inc. | Methods of treating cancer |
CN102241648B (zh) * | 2011-01-31 | 2016-08-03 | 沈阳东星医药科技有限公司 | 抗多药耐药紫杉烷类衍生物及其制备方法和应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601676B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
US4876399A (en) | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
US5136060A (en) | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
US5015744A (en) | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
US5645988A (en) | 1991-05-08 | 1997-07-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of identifying drugs with selective effects against cancer cells |
AU2005692A (en) | 1991-05-08 | 1992-12-21 | United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Method for designing cancer treatment regimens and methods and pharmaceutical compositions for the treatment of cancer |
US5229526A (en) | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
US5284864A (en) | 1991-09-23 | 1994-02-08 | Florida State University | Butenyl substituted taxanes and pharmaceutical compositions containing them |
US5262409A (en) | 1991-10-11 | 1993-11-16 | Fred Hutchinson Cancer Research Center | Binary tumor therapy |
US5294737A (en) | 1992-02-27 | 1994-03-15 | The Research Foundation State University Of New York | Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom |
FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
EP0982028A1 (en) * | 1998-08-20 | 2000-03-01 | Aventis Pharma S.A. | New use of taxoid derivatives |
-
2001
- 2001-03-21 US US09/813,018 patent/US6441026B1/en not_active Expired - Fee Related
-
2002
- 2002-03-21 PT PT02713093T patent/PT1478355E/pt unknown
- 2002-03-21 SI SI200230525T patent/SI1478355T1/sl unknown
- 2002-03-21 EP EP02713093A patent/EP1478355B1/en not_active Expired - Lifetime
- 2002-03-21 DK DK02713093T patent/DK1478355T3/da active
- 2002-03-21 DE DE60218751T patent/DE60218751T2/de not_active Expired - Lifetime
- 2002-03-21 WO PCT/IB2002/002239 patent/WO2002074232A2/en not_active Application Discontinuation
- 2002-03-21 ES ES02713093T patent/ES2282400T3/es not_active Expired - Lifetime
- 2002-03-21 CN CNA028068572A patent/CN1536995A/zh active Pending
- 2002-03-21 CN CNA2009101299448A patent/CN101590057A/zh active Pending
- 2002-03-21 HU HU0500478A patent/HUP0500478A2/hu unknown
- 2002-03-21 WO PCT/IB2002/000853 patent/WO2002074289A2/en active IP Right Grant
- 2002-03-21 EA EA200301047A patent/EA006878B1/ru not_active IP Right Cessation
- 2002-03-21 AU AU2002244877A patent/AU2002244877B2/en not_active Ceased
- 2002-03-21 BR BR0208274-8A patent/BR0208274A/pt not_active IP Right Cessation
- 2002-03-21 AT AT02713093T patent/ATE355837T1/de active
- 2002-03-21 JP JP2002572997A patent/JP4467885B2/ja not_active Expired - Lifetime
- 2002-03-21 MX MXPA03008539A patent/MXPA03008539A/es active IP Right Grant
- 2002-03-21 CA CA2440160A patent/CA2440160C/en not_active Expired - Lifetime
-
2003
- 2003-09-18 IL IL157992A patent/IL157992A/en not_active IP Right Cessation
-
2007
- 2007-05-10 CY CY20071100643T patent/CY1106582T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1478355B1 (en) | 2007-03-07 |
DE60218751D1 (de) | 2007-04-19 |
AU2002244877B2 (en) | 2006-07-20 |
SI1478355T1 (sl) | 2007-08-31 |
CN1536995A (zh) | 2004-10-13 |
US20020031505A1 (en) | 2002-03-14 |
CN101590057A (zh) | 2009-12-02 |
JP4467885B2 (ja) | 2010-05-26 |
WO2002074289A3 (en) | 2004-09-02 |
WO2002074232A2 (en) | 2002-09-26 |
EA200301047A1 (ru) | 2004-06-24 |
IL157992A (en) | 2008-08-07 |
MXPA03008539A (es) | 2004-08-11 |
DE60218751T2 (de) | 2007-11-22 |
BR0208274A (pt) | 2004-07-13 |
HUP0500478A2 (hu) | 2005-08-29 |
EP1478355A2 (en) | 2004-11-24 |
ATE355837T1 (de) | 2007-03-15 |
PT1478355E (pt) | 2007-05-31 |
DK1478355T3 (da) | 2007-07-02 |
ES2282400T3 (es) | 2007-10-16 |
CA2440160A1 (en) | 2002-09-26 |
WO2002074289A2 (en) | 2002-09-26 |
JP2004536790A (ja) | 2004-12-09 |
US6441026B1 (en) | 2002-08-27 |
CA2440160C (en) | 2011-07-05 |
EA006878B1 (ru) | 2006-04-28 |
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