EA200301047A1 - Противоопухолевые составы, содержащие производные таксанов - Google Patents

Противоопухолевые составы, содержащие производные таксанов

Info

Publication number
EA200301047A1
EA200301047A1 EA200301047A EA200301047A EA200301047A1 EA 200301047 A1 EA200301047 A1 EA 200301047A1 EA 200301047 A EA200301047 A EA 200301047A EA 200301047 A EA200301047 A EA 200301047A EA 200301047 A1 EA200301047 A1 EA 200301047A1
Authority
EA
Eurasian Patent Office
Prior art keywords
taxans
compositions containing
containing derivatives
tumor compositions
tumor
Prior art date
Application number
EA200301047A
Other languages
English (en)
Other versions
EA006878B1 (ru
Inventor
Мари-Кристин Биссери
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200301047A1 publication Critical patent/EA200301047A1/ru
Publication of EA006878B1 publication Critical patent/EA006878B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Описан фармацевтический состав, содержащий ацетоциклопропилтаксотер или его производное, а также по крайней мере одно из соединений: алкилирующее средство, антиметаболит, веретенный яд, эпидофиллотоксин, антибиотик, фермент, ингибитор топоизомеразы, платиновый координационный комплекс, модификатор биологических реакций и/или ингибитор факторов роста.
EA200301047A 2001-03-21 2002-03-21 Противоопухолевые составы, содержащие производные таксанов EA006878B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/813,018 US6441026B1 (en) 1993-11-08 2001-03-21 Antitumor compositions containing taxane derivatives
PCT/IB2002/000853 WO2002074289A2 (en) 2001-03-21 2002-03-21 Antitumor compositions containing taxane derivatives

Publications (2)

Publication Number Publication Date
EA200301047A1 true EA200301047A1 (ru) 2004-06-24
EA006878B1 EA006878B1 (ru) 2006-04-28

Family

ID=25211230

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301047A EA006878B1 (ru) 2001-03-21 2002-03-21 Противоопухолевые составы, содержащие производные таксанов

Country Status (19)

Country Link
US (1) US6441026B1 (ru)
EP (1) EP1478355B1 (ru)
JP (1) JP4467885B2 (ru)
CN (2) CN1536995A (ru)
AT (1) ATE355837T1 (ru)
AU (1) AU2002244877B2 (ru)
BR (1) BR0208274A (ru)
CA (1) CA2440160C (ru)
CY (1) CY1106582T1 (ru)
DE (1) DE60218751T2 (ru)
DK (1) DK1478355T3 (ru)
EA (1) EA006878B1 (ru)
ES (1) ES2282400T3 (ru)
HU (1) HUP0500478A2 (ru)
IL (1) IL157992A (ru)
MX (1) MXPA03008539A (ru)
PT (1) PT1478355E (ru)
SI (1) SI1478355T1 (ru)
WO (2) WO2002074289A2 (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
WO2002072085A1 (en) * 2001-03-14 2002-09-19 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
ITRM20020191A1 (it) * 2002-04-08 2003-10-08 Sigma Tau Ind Farmaceuti Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie tumorali associate ad una alterata att
KR20050000544A (ko) * 2002-05-17 2005-01-05 아방티 파르마 소시에테 아노님 유방암 및 난소암의 보조 요법에서도세탁셀/독소루비신/사이클로포스파미드의 용도
AU2003287081A1 (en) * 2002-10-16 2004-05-04 Ilex Products, Inc. Clofarabine and taxane chemotherapy combination
ITMI20030317A1 (it) * 2003-02-21 2004-08-22 Pharmacia Italia Spa Terapia combinata comprendente un derivato dell'indolopirrolocarbazolo ed un altro agente antitumorale.
WO2004103344A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
CN100340296C (zh) * 2005-02-03 2007-10-03 山东蓝金生物工程有限公司 一种抗癌体内植入剂
US8735394B2 (en) * 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
CA3054535A1 (en) 2005-02-18 2006-08-24 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
JP5237821B2 (ja) 2005-12-05 2013-07-17 日東電工株式会社 ポリグルタミン酸−アミノ酸結合体および方法
EP1913958B1 (en) * 2006-08-03 2009-12-23 Sanofi-Aventis Antitumor compositions containing acetylcyclopropyl docetaxel and trastuzumab
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN104800856A (zh) * 2007-04-10 2015-07-29 日东电工株式会社 多功能聚谷氨酸盐药物载体
WO2008141111A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Polymers conjugated with platinum drugs
EP2155255B1 (en) 2007-05-09 2013-08-14 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
JP2010526917A (ja) * 2007-05-09 2010-08-05 日東電工株式会社 複数種の薬物を有するポリグルタミン酸塩複合体及びポリグルタミン酸塩−アミノ酸複合体
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
NZ602385A (en) 2010-03-29 2014-08-29 Abraxis Bioscience Llc Methods of treating cancer
CN107158389A (zh) 2010-03-29 2017-09-15 阿布拉科斯生物科学有限公司 增强药物递送和治疗剂有效性的方法
WO2011153010A1 (en) 2010-06-04 2011-12-08 Abraxis Biosciences, Llc Methods of treatment of pancreatic cancer
CA2817219A1 (en) * 2010-11-12 2012-05-18 Endocyte, Inc. Methods of treating cancer
CN102241648B (zh) * 2011-01-31 2016-08-03 沈阳东星医药科技有限公司 抗多药耐药紫杉烷类衍生物及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
AU2005692A (en) 1991-05-08 1992-12-21 United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method for designing cancer treatment regimens and methods and pharmaceutical compositions for the treatment of cancer
US5645988A (en) 1991-05-08 1997-07-08 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying drugs with selective effects against cancer cells
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5262409A (en) 1991-10-11 1993-11-16 Fred Hutchinson Cancer Research Center Binary tumor therapy
US5294737A (en) 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives

Also Published As

Publication number Publication date
BR0208274A (pt) 2004-07-13
CA2440160A1 (en) 2002-09-26
MXPA03008539A (es) 2004-08-11
EA006878B1 (ru) 2006-04-28
DE60218751D1 (de) 2007-04-19
US20020031505A1 (en) 2002-03-14
ATE355837T1 (de) 2007-03-15
CN101590057A (zh) 2009-12-02
JP4467885B2 (ja) 2010-05-26
EP1478355A2 (en) 2004-11-24
DK1478355T3 (da) 2007-07-02
SI1478355T1 (sl) 2007-08-31
JP2004536790A (ja) 2004-12-09
EP1478355B1 (en) 2007-03-07
PT1478355E (pt) 2007-05-31
CA2440160C (en) 2011-07-05
WO2002074289A3 (en) 2004-09-02
DE60218751T2 (de) 2007-11-22
AU2002244877B2 (en) 2006-07-20
IL157992A (en) 2008-08-07
ES2282400T3 (es) 2007-10-16
CY1106582T1 (el) 2012-01-25
WO2002074232A2 (en) 2002-09-26
HUP0500478A2 (hu) 2005-08-29
CN1536995A (zh) 2004-10-13
WO2002074289A2 (en) 2002-09-26
US6441026B1 (en) 2002-08-27

Similar Documents

Publication Publication Date Title
EA200301047A1 (ru) Противоопухолевые составы, содержащие производные таксанов
MY134586A (en) Novel pyrroles derivatives as pharmaceutical agents
EA200300248A1 (ru) Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
ES2182234T3 (es) Inhibidores de metaloproteasa.
AR011116A1 (es) Compuesto derivado de n-hidroxi-beta-sulfonil propionamida y composicion farmaceutica que lo contiene
DE60204452D1 (de) Pyrazolo[1,5]pyridinderivate
ES2175624T3 (es) Derivados de pirazolo(4,3-d)pirimidina y composiciones farmaceuticas que los contienen.
TR199800585T2 (xx) COX-2 �nhibit�rleri Olarak (Metils�lfonil)Fenil-2-(5H)-Furanonlar.
DE69232929D1 (de) Saccharinderivate als proteolytische Enzyminhibitoren
ECSP045378A (es) Derivados novedosos de diazabiciclononeno
NO20000313L (no) Nye forbindelser
ES2243579T3 (es) Derivados de pirazolopirideno.
DE60003220D1 (de) [1,2,3]-TRIAZOLO[4,5-d]PYRIMIDIN-DERIVATE ALS ANTITHROMBOTISCHE MITTEL
EA199800773A1 (ru) Производные пирролопирролона в качестве ингибиторов нейтрофильной эластазы
CA2238875A1 (en) Tri-aryl ethane derivatives as pde iv inhibitors
IL100612A0 (en) Cyclic ketal derivatives,their preparation and pharmaceutical compositions containing them
SE9804212D0 (sv) Compounds
CA2266759A1 (en) 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
ATE207076T1 (de) Ara-c derivate
SE9802574D0 (sv) Novel compounds
EA200100984A1 (ru) Новые кристаллические формы макролидного антибиотика
IS5390A (is) Bensoxazín og bensóþíazín afleiður og notkun þeirra í lyf
ATE274515T1 (de) Pyrazolopyridinderivate
AU2002357740A1 (en) Pyrazolo-pyridine derivatives as antiherpes agents

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU