CY1105936T1 - Μεταλλαγμενα στελεχη ικανα να παραγουν πρωτεϊνες χημικως διαφοροποιημενες με ενσωματωση μη συμβατικων αμινοξεων - Google Patents
Μεταλλαγμενα στελεχη ικανα να παραγουν πρωτεϊνες χημικως διαφοροποιημενες με ενσωματωση μη συμβατικων αμινοξεωνInfo
- Publication number
- CY1105936T1 CY1105936T1 CY20071100069T CY071100069T CY1105936T1 CY 1105936 T1 CY1105936 T1 CY 1105936T1 CY 20071100069 T CY20071100069 T CY 20071100069T CY 071100069 T CY071100069 T CY 071100069T CY 1105936 T1 CY1105936 T1 CY 1105936T1
- Authority
- CY
- Cyprus
- Prior art keywords
- incorporation
- amino acids
- mutant strains
- chemically different
- produce proteins
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 238000010348 incorporation Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000006065 biodegradation reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 210000001236 prokaryotic cell Anatomy 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
Abstract
Η παρούσα εφεύρεση έχει ως αντικείμενο μεταλλαγμένα προκαρυωτικά κύτταρα, και ιδιαίτερα Ε. coli, ικανά να παράγουν πρωτεΐνες των οποίων οι αμινοξικές αλληλουχίες περιέχουν τουλάχιστον ένα μη συμβατικό αμινοξύ, μεθόδους παραγωγής και καθαρισμού των αναφερόμενων πρωτεϊνών όπως επίσης και των πρωτεϊνών που λαμβάνονται με τις μεθόδους σύμφωνα με την εφεύρεση. Η εφεύρεση περιλαμβάνει επίσης εφαρμογές των αναφερόμενων κυττάρων και πρωτεϊνών σε διαφορετικούς τομείς όπως στην θεραπεία, τα καλλυντικά, τη διάγνωση ή τη βιοσύνθεση ή βιοαποικοδόμηση οργανικών ενώσεων.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0005547A FR2808284B1 (fr) | 2000-04-28 | 2000-04-28 | Souches mutantes capables de produire des proteines chimiquement diversifiees par incorporation d'acides amines non conventionnels |
| PCT/FR2001/001306 WO2001083718A1 (fr) | 2000-04-28 | 2001-04-27 | Souches mutantes capables de produire des proteines chimiquement diversifiees par incorporation d'acides amines non conventionnels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105936T1 true CY1105936T1 (el) | 2011-04-06 |
Family
ID=8849772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100069T CY1105936T1 (el) | 2000-04-28 | 2007-01-17 | Μεταλλαγμενα στελεχη ικανα να παραγουν πρωτεϊνες χημικως διαφοροποιημενες με ενσωματωση μη συμβατικων αμινοξεων |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040014942A1 (el) |
| EP (1) | EP1280890B1 (el) |
| JP (1) | JP2004518404A (el) |
| AT (1) | ATE350469T1 (el) |
| AU (2) | AU5643301A (el) |
| CA (1) | CA2407595A1 (el) |
| CY (1) | CY1105936T1 (el) |
| DE (1) | DE60125754T2 (el) |
| DK (1) | DK1280890T3 (el) |
| ES (1) | ES2273836T3 (el) |
| FR (1) | FR2808284B1 (el) |
| MX (1) | MXPA02010462A (el) |
| NZ (1) | NZ522805A (el) |
| PT (1) | PT1280890E (el) |
| WO (1) | WO2001083718A1 (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE344836T1 (de) | 2001-04-19 | 2006-11-15 | Pasteur Institut | Methode für die erweiterung der chemischen zusammensetzung von proteinen produziert in vivo unter verwendung von mutierten aminoacyl-trna- synthetasen ohne korrekturfunktion |
| EP1251175B1 (en) * | 2001-04-19 | 2006-11-08 | Institut Pasteur | Method for diversifying the chemical composition of protein produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2785291B1 (fr) * | 1998-10-28 | 2003-03-07 | Pasteur Institut | Procede de production in vivo de proteines chimiquement diversifiees par incorporation d'acides amines non conventionnels |
-
2000
- 2000-04-28 FR FR0005547A patent/FR2808284B1/fr not_active Expired - Fee Related
-
2001
- 2001-04-27 AU AU5643301A patent/AU5643301A/xx active Pending
- 2001-04-27 DK DK01929739T patent/DK1280890T3/da active
- 2001-04-27 ES ES01929739T patent/ES2273836T3/es not_active Expired - Lifetime
- 2001-04-27 MX MXPA02010462A patent/MXPA02010462A/es active IP Right Grant
- 2001-04-27 AU AU2001256433A patent/AU2001256433B2/en not_active Ceased
- 2001-04-27 WO PCT/FR2001/001306 patent/WO2001083718A1/fr active IP Right Grant
- 2001-04-27 JP JP2001580326A patent/JP2004518404A/ja active Pending
- 2001-04-27 DE DE60125754T patent/DE60125754T2/de not_active Expired - Lifetime
- 2001-04-27 AT AT01929739T patent/ATE350469T1/de active
- 2001-04-27 EP EP01929739A patent/EP1280890B1/fr not_active Expired - Lifetime
- 2001-04-27 US US10/258,795 patent/US20040014942A1/en not_active Abandoned
- 2001-04-27 NZ NZ522805A patent/NZ522805A/en not_active IP Right Cessation
- 2001-04-27 PT PT01929739T patent/PT1280890E/pt unknown
- 2001-04-27 CA CA002407595A patent/CA2407595A1/fr not_active Abandoned
-
2007
- 2007-01-17 CY CY20071100069T patent/CY1105936T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2808284A1 (fr) | 2001-11-02 |
| JP2004518404A (ja) | 2004-06-24 |
| DE60125754D1 (de) | 2007-02-15 |
| MXPA02010462A (es) | 2003-05-23 |
| AU2001256433C1 (en) | 2001-11-12 |
| DE60125754T2 (de) | 2007-10-31 |
| CA2407595A1 (fr) | 2001-11-08 |
| EP1280890A1 (fr) | 2003-02-05 |
| EP1280890B1 (fr) | 2007-01-03 |
| ES2273836T3 (es) | 2007-05-16 |
| AU2001256433B2 (en) | 2006-07-06 |
| WO2001083718A1 (fr) | 2001-11-08 |
| PT1280890E (pt) | 2007-02-28 |
| AU5643301A (en) | 2001-11-12 |
| FR2808284B1 (fr) | 2004-11-19 |
| DK1280890T3 (da) | 2007-03-12 |
| US20040014942A1 (en) | 2004-01-22 |
| ATE350469T1 (de) | 2007-01-15 |
| NZ522805A (en) | 2004-09-24 |
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