CY1105334T1 - Μεθοδος παρασκευης της 1,3- προπανοδιολης απο εναν ανασυνδυασμενο μικροοργανισμο εν απουσια συνενζυμου β12 ή ενος απο τους προδρομους του - Google Patents
Μεθοδος παρασκευης της 1,3- προπανοδιολης απο εναν ανασυνδυασμενο μικροοργανισμο εν απουσια συνενζυμου β12 ή ενος απο τους προδρομους τουInfo
- Publication number
- CY1105334T1 CY1105334T1 CY20061101294T CY061101294T CY1105334T1 CY 1105334 T1 CY1105334 T1 CY 1105334T1 CY 20061101294 T CY20061101294 T CY 20061101294T CY 061101294 T CY061101294 T CY 061101294T CY 1105334 T1 CY1105334 T1 CY 1105334T1
- Authority
- CY
- Cyprus
- Prior art keywords
- coenzyme
- propanediol
- precursors
- absence
- relates
- Prior art date
Links
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 title abstract 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 title abstract 3
- 239000002243 precursor Substances 0.000 title abstract 3
- 244000005700 microbiome Species 0.000 title abstract 2
- 239000005515 coenzyme Substances 0.000 title 1
- OAJLVMGLJZXSGX-SLAFOUTOSA-L (2s,3s,4r,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7 Chemical compound [Co+3].O[C@H]1[C@@H](O)[C@@H]([CH2-])O[C@@H]1N1C2=NC=NC(N)=C2N=C1.[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-SLAFOUTOSA-L 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 101710088194 Dehydrogenase Proteins 0.000 abstract 1
- 108010025885 Glycerol dehydratase Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003575 carbonaceous material Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μία μέθοδο παρασκευής της 1,3-προπανοδιόλης από μία ανθρακούχο ουσία, η οποία μέθοδος περιλαμβάνει ένα στάδιο καλλιεργείας ενός ανασυνδυασμένου μικροοργανισμού μη παραγωγού συνενζύμου Β12 εν απουσία προσθήκης συνενζύμου Β12 ή ενός από τους προδρόμους του. Η εφεύρεση αφορά επίσης ένα νουκλεϊνικό οξύ το οποίο κωδικοποιεί μία αφυδατάση γλυκερόλης της οποίας η καταλυτική δράση είναι ανεξάρτητη από την παρουσία συνενζύμου Β12 ή ενός από τους προδρόμους του καθώς και ένα νουκλεϊνικό οξύ το οποίο κωδικοποιεί την αφυδρογονάση της 1,3-προπανόλης η οποία παρεμβαίνει στη σύνθεση της 1,3-προπανοδιόλης. Η εφεύρεση είναι επίσης σχετική με ανασυνδυασμένους φορείς και κύτταρα ξενιστές περιλαμβάνοντα τέτοια νουκλεϊνικά οξέα καθώς και τα πολυπεπτίδια τα κωδικοποιούμενα από αυτά τα τελευταία.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9908939A FR2796081B1 (fr) | 1999-07-09 | 1999-07-09 | Procede de preparation du 1,3-propanediol par un micro-organisme recombinant en l'absence de coenzyme b12 ou de l'un de ses precurseurs |
| PCT/FR2000/001981 WO2001004324A1 (fr) | 1999-07-09 | 2000-07-07 | Procede de preparation du 1,3-propanediol par un micro-organisme recombinant en l'absence de coenzyme b12 ou de l'un de ses precurseurs |
| US10/043,639 US7267972B2 (en) | 1999-07-09 | 2002-01-09 | Method for preparing 1,3-propanediol by a recombinant micro-organism in the absence of coenzyme b12 or one of its precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105334T1 true CY1105334T1 (el) | 2010-03-03 |
Family
ID=29720861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101294T CY1105334T1 (el) | 1999-07-09 | 2006-09-12 | Μεθοδος παρασκευης της 1,3- προπανοδιολης απο εναν ανασυνδυασμενο μικροοργανισμο εν απουσια συνενζυμου β12 ή ενος απο τους προδρομους του |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7267972B2 (el) |
| EP (1) | EP1200597B1 (el) |
| AT (1) | ATE330014T1 (el) |
| AU (1) | AU6296400A (el) |
| CY (1) | CY1105334T1 (el) |
| DE (1) | DE60028777T2 (el) |
| DK (1) | DK1200597T3 (el) |
| ES (1) | ES2264936T3 (el) |
| FR (1) | FR2796081B1 (el) |
| PT (1) | PT1200597E (el) |
| WO (1) | WO2001004324A1 (el) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796081B1 (fr) | 1999-07-09 | 2003-09-26 | Agronomique Inst Nat Rech | Procede de preparation du 1,3-propanediol par un micro-organisme recombinant en l'absence de coenzyme b12 ou de l'un de ses precurseurs |
| EP1583818A4 (en) | 2002-12-16 | 2007-08-15 | Du Pont | B12 DEPENDENT DEHYDRATASES WITH IMPROVED REACTION KINETICS |
| CN1935991B (zh) * | 2006-06-21 | 2010-05-12 | 南宁中诺生物工程有限责任公司 | 产气荚膜梭菌甘油脱水酶基因及其1,3-丙二醇的生产方法 |
| WO2008052595A1 (en) | 2006-10-31 | 2008-05-08 | Metabolic Explorer | Process for the biological production of 1,3-propanediol from glycerol with high yield |
| WO2008052596A1 (en) * | 2006-10-31 | 2008-05-08 | Metabolic Explorer | Process for the biological production of n-butanol with high yield |
| DE102007027006A1 (de) * | 2007-06-08 | 2008-12-11 | Evonik Degussa Gmbh | Mikrobiologische Herstellung von Aldehyden, insbesondere von 3-Hydroxypropionaldehyd |
| CN102341502B (zh) | 2008-12-31 | 2015-07-01 | 代谢探索者公司 | 用于制备二醇的方法 |
| EP2248904A1 (en) * | 2009-05-05 | 2010-11-10 | Metabolic Explorer | Continuous culture for 1,3-propanediol production using high glycerine concentration |
| DE102009002811A1 (de) * | 2009-05-05 | 2010-11-11 | Evonik Degussa Gmbh | Enzymatisches Verfahren zur Herstellung von Aldehyden |
| NZ624392A (en) | 2009-08-21 | 2015-12-24 | Lallemand Hungary Liquidity Man Llc | Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms |
| WO2011042434A1 (en) | 2009-10-05 | 2011-04-14 | Metabolic Explorer | 1,3-propanediol production with immobilised cells reactors |
| KR101090362B1 (ko) | 2009-10-29 | 2011-12-07 | 한국생명공학연구원 | 글리세롤로부터 3-하이드록시프로피온산을 생산하는 새로운 방법 |
| KR101220499B1 (ko) * | 2010-05-25 | 2013-01-10 | 한국생명공학연구원 | 글리세롤로부터 3-하이드록시프로피온산을 고수율로 제조하는 방법 |
| AR083799A1 (es) | 2010-11-10 | 2013-03-20 | Metabolic Explorer Sa | Microorganismos para la produccion de 1,3-propanodiol usando concentracion de glicerina alta |
| EP2540834A1 (en) * | 2011-06-29 | 2013-01-02 | Metabolic Explorer | Method for the preparation of 1,3-propanediol |
| US8673602B2 (en) * | 2011-08-16 | 2014-03-18 | E I Du Pont De Nemours And Company | Recombinant bacteria having improved sucrose utilization |
| US9527953B2 (en) | 2012-11-19 | 2016-12-27 | Samsung Electronics Co., Ltd. | Continuous preparation for polyester |
| US9501147B2 (en) * | 2013-12-29 | 2016-11-22 | Immersion Corporation | Haptic device incorporating stretch characteristics |
| HUE053088T2 (hu) | 2015-07-27 | 2021-06-28 | Institut Nat Des Sciences Appliquees | Ferredoxin-NADP+ reduktáz aktivitású új polipeptid, az azt kódoló polinukleotid és alkalmazásaik |
| PT3583221T (pt) | 2017-02-20 | 2021-09-24 | Metabolic Explorer Sa | Consórcio microbiano compreendendo clostridia para a produção de 1,3-propanodiol a partir de glicerol |
| EP3438270A1 (en) | 2017-08-04 | 2019-02-06 | Metabolic Explorer | Microorganism and method for improved 1,3-propanediol production by fermentation on a culture medium with high glycerine content |
| AR114547A1 (es) | 2018-08-10 | 2020-09-16 | Metabolic Explorer Sa | Microorganismos con producción mejorada de 1,3-propanodiol y ácido butírico |
| JP2023544155A (ja) * | 2020-09-30 | 2023-10-20 | ゲノミウム，インコーポレイテッド | バイオアクロレイン及びバイオアクリル酸を生成するための発酵プロセス |
| CN112358986B (zh) * | 2020-11-09 | 2022-10-21 | 华南理工大学 | 一种丁酸梭菌及其在固定化发酵生产1，3-丙二醇的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633362A (en) | 1995-05-12 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Production of 1,3-propanediol from glycerol by recombinant bacteria expressing recombinant diol dehydratase |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| KR100509310B1 (ko) | 1996-11-13 | 2005-08-22 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 재조합 유기체에 의한 1,3-프로판디올의 생산 방법 |
| FR2796081B1 (fr) | 1999-07-09 | 2003-09-26 | Agronomique Inst Nat Rech | Procede de preparation du 1,3-propanediol par un micro-organisme recombinant en l'absence de coenzyme b12 ou de l'un de ses precurseurs |
-
1999
- 1999-07-09 FR FR9908939A patent/FR2796081B1/fr not_active Expired - Lifetime
-
2000
- 2000-07-07 DK DK00949686T patent/DK1200597T3/da active
- 2000-07-07 AU AU62964/00A patent/AU6296400A/en not_active Abandoned
- 2000-07-07 EP EP00949686A patent/EP1200597B1/fr not_active Expired - Lifetime
- 2000-07-07 WO PCT/FR2000/001981 patent/WO2001004324A1/fr active IP Right Grant
- 2000-07-07 ES ES00949686T patent/ES2264936T3/es not_active Expired - Lifetime
- 2000-07-07 DE DE60028777T patent/DE60028777T2/de not_active Expired - Lifetime
- 2000-07-07 PT PT00949686T patent/PT1200597E/pt unknown
- 2000-07-07 AT AT00949686T patent/ATE330014T1/de active
-
2002
- 2002-01-09 US US10/043,639 patent/US7267972B2/en not_active Expired - Lifetime
-
2006
- 2006-09-12 CY CY20061101294T patent/CY1105334T1/el unknown
-
2007
- 2007-08-15 US US11/839,455 patent/US7695943B2/en not_active Expired - Fee Related
-
2010
- 2010-01-04 US US12/651,899 patent/US7858355B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE330014T1 (de) | 2006-07-15 |
| DK1200597T3 (da) | 2006-10-23 |
| US20100129892A1 (en) | 2010-05-27 |
| EP1200597B1 (fr) | 2006-06-14 |
| ES2264936T3 (es) | 2007-02-01 |
| US20090029431A1 (en) | 2009-01-29 |
| FR2796081B1 (fr) | 2003-09-26 |
| WO2001004324A1 (fr) | 2001-01-18 |
| EP1200597A1 (fr) | 2002-05-02 |
| FR2796081A1 (fr) | 2001-01-12 |
| DE60028777D1 (de) | 2006-07-27 |
| US7858355B2 (en) | 2010-12-28 |
| US7267972B2 (en) | 2007-09-11 |
| US7695943B2 (en) | 2010-04-13 |
| AU6296400A (en) | 2001-01-30 |
| PT1200597E (pt) | 2006-09-29 |
| DE60028777T2 (de) | 2007-05-31 |
| US20030175916A1 (en) | 2003-09-18 |
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