CU23679A1 - Variantes de pertactinas para uso vacunal - Google Patents
Variantes de pertactinas para uso vacunalInfo
- Publication number
- CU23679A1 CU23679A1 CU20070240A CU20070240A CU23679A1 CU 23679 A1 CU23679 A1 CU 23679A1 CU 20070240 A CU20070240 A CU 20070240A CU 20070240 A CU20070240 A CU 20070240A CU 23679 A1 CU23679 A1 CU 23679A1
- Authority
- CU
- Cuba
- Prior art keywords
- engineering
- vaccines
- pertactin
- pertactines
- vaccine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 108010021711 pertactin Proteins 0.000 abstract 2
- 241000588832 Bordetella pertussis Species 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 229960001212 bacterial vaccine Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000625 opsonophagocytic effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se enmarca en el campo de la biomedicina, y comprende la ingenierización de la proteína pertactina (Prn) para su obtención y uso en vacunas bacterianas, más particularmente en vacunas acelulares contra Bordetella pertussis. Las pertactinas ingenierizadas abarcan en su estructura el polimorfismo de diferentes cepas, y al ensayarse como vacunas inducen una respuesta de anticuerpos de mayor capacidad protectora y de mayor actividad opsonofagocítica. Las variantes ingenierizadas de pertactina de esta invención son aplicables en la medicina humana y veterinaria.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20070240A CU23679A1 (es) | 2007-10-30 | 2007-10-30 | Variantes de pertactinas para uso vacunal |
EP08845509A EP2216045A1 (en) | 2007-10-30 | 2008-10-17 | Engineered pertactin variants for vaccine use |
PCT/CU2008/000009 WO2009056076A1 (es) | 2007-10-30 | 2008-10-17 | Variantes ingenierizadas de pertactina para uso vacunal |
KR1020107011928A KR20100093548A (ko) | 2007-10-30 | 2008-10-17 | 백신 용도의 유전자 조작된 퍼탁틴 변이체 |
CA2702697A CA2702697A1 (en) | 2007-10-30 | 2008-10-17 | Engineered pertactin variants for vaccine use |
US12/739,658 US8569470B2 (en) | 2007-10-30 | 2008-10-17 | Engineered pertactin variants for vaccine use |
MX2010004706A MX2010004706A (es) | 2007-10-30 | 2008-10-17 | Variantes ingenierizadas de pertactina para uso vacunal. |
CN2008801141194A CN101878038B (zh) | 2007-10-30 | 2008-10-17 | 用于疫苗用途的经改造的百日咳杆菌粘附素变体 |
BRPI0817898 BRPI0817898A2 (pt) | 2007-10-30 | 2008-10-17 | Sequência polinucleotídica, composição farmacêutica, vacina, vetor de expressão em mamíferos, vacina, método para a deteccção de infecção por bordetella, e, kit diagnóstico para a detecção de presença ou ausência de anticorpos contra bordetella |
RU2010121646/10A RU2499046C2 (ru) | 2007-10-30 | 2008-10-17 | Полинуклеотидная последовательность, кодирующая сконструированный белок пертактин, вектор, включающий такую последовательность, и вакцинные композиции, содержащие белок пертактина или вектор |
ARP080104709A AR069086A1 (es) | 2007-10-30 | 2008-10-28 | Variantes ingenierizadas de pertactina para uso vacunal |
US13/966,948 US20140011216A1 (en) | 2007-10-30 | 2013-08-14 | Engineered pertactin variants for vaccine use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20070240A CU23679A1 (es) | 2007-10-30 | 2007-10-30 | Variantes de pertactinas para uso vacunal |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23679A1 true CU23679A1 (es) | 2011-07-11 |
Family
ID=40473455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20070240A CU23679A1 (es) | 2007-10-30 | 2007-10-30 | Variantes de pertactinas para uso vacunal |
Country Status (11)
Country | Link |
---|---|
US (2) | US8569470B2 (es) |
EP (1) | EP2216045A1 (es) |
KR (1) | KR20100093548A (es) |
CN (1) | CN101878038B (es) |
AR (1) | AR069086A1 (es) |
BR (1) | BRPI0817898A2 (es) |
CA (1) | CA2702697A1 (es) |
CU (1) | CU23679A1 (es) |
MX (1) | MX2010004706A (es) |
RU (1) | RU2499046C2 (es) |
WO (1) | WO2009056076A1 (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60133734T2 (de) | 2000-05-25 | 2009-05-14 | Institut Pasteur | Polypeptide die polymorphismen aus bordertella pertussis, bordetella parapertussis und bordetella bronchiseptica pertactin wiederholende regionen enthalten, ihre verwendung in diagnostik und immunogene zusammensetzungen |
EP1174505A1 (en) | 2000-06-30 | 2002-01-23 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | (Poly)peptides for the preparation of vaccines against Bordetella pertussis and/or Bordetella parapertussis, vaccines based upon such (poly)peptides, and antibodies against such peptides |
CA2539715C (en) * | 2003-10-02 | 2015-02-24 | Glaxosmithkline Biologicals S.A. | Pertussis antigens and use thereof in vaccination |
UA40596U (ru) * | 2006-05-16 | 2009-04-27 | Институт Проблем Безопасности Атомных Электростанций Национальной Академии Наук Украины | Энергоблок атомной электростанции |
-
2007
- 2007-10-30 CU CU20070240A patent/CU23679A1/es not_active IP Right Cessation
-
2008
- 2008-10-17 RU RU2010121646/10A patent/RU2499046C2/ru not_active IP Right Cessation
- 2008-10-17 CN CN2008801141194A patent/CN101878038B/zh not_active Expired - Fee Related
- 2008-10-17 EP EP08845509A patent/EP2216045A1/en not_active Withdrawn
- 2008-10-17 MX MX2010004706A patent/MX2010004706A/es active IP Right Grant
- 2008-10-17 KR KR1020107011928A patent/KR20100093548A/ko not_active Application Discontinuation
- 2008-10-17 US US12/739,658 patent/US8569470B2/en not_active Expired - Fee Related
- 2008-10-17 CA CA2702697A patent/CA2702697A1/en not_active Abandoned
- 2008-10-17 BR BRPI0817898 patent/BRPI0817898A2/pt not_active IP Right Cessation
- 2008-10-17 WO PCT/CU2008/000009 patent/WO2009056076A1/es active Application Filing
- 2008-10-28 AR ARP080104709A patent/AR069086A1/es unknown
-
2013
- 2013-08-14 US US13/966,948 patent/US20140011216A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0817898A2 (pt) | 2015-05-05 |
US20140011216A1 (en) | 2014-01-09 |
KR20100093548A (ko) | 2010-08-25 |
MX2010004706A (es) | 2010-05-27 |
CN101878038B (zh) | 2013-11-06 |
RU2499046C2 (ru) | 2013-11-20 |
CN101878038A (zh) | 2010-11-03 |
RU2010121646A (ru) | 2011-12-10 |
US20110070265A1 (en) | 2011-03-24 |
EP2216045A1 (en) | 2010-08-11 |
AR069086A1 (es) | 2009-12-30 |
WO2009056076A1 (es) | 2009-05-07 |
CA2702697A1 (en) | 2009-05-07 |
US8569470B2 (en) | 2013-10-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Lapse (for not paying fees) |