CU23679A1 - Variantes de pertactinas para uso vacunal - Google Patents
Variantes de pertactinas para uso vacunalInfo
- Publication number
- CU23679A1 CU23679A1 CU20070240A CU20070240A CU23679A1 CU 23679 A1 CU23679 A1 CU 23679A1 CU 20070240 A CU20070240 A CU 20070240A CU 20070240 A CU20070240 A CU 20070240A CU 23679 A1 CU23679 A1 CU 23679A1
- Authority
- CU
- Cuba
- Prior art keywords
- engineering
- vaccines
- pertactin
- pertactines
- vaccine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 108010021711 pertactin Proteins 0.000 abstract 2
- 241000588832 Bordetella pertussis Species 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 229960001212 bacterial vaccine Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000625 opsonophagocytic effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se enmarca en el campo de la biomedicina, y comprende la ingenierización de la proteína pertactina (Prn) para su obtención y uso en vacunas bacterianas, más particularmente en vacunas acelulares contra Bordetella pertussis. Las pertactinas ingenierizadas abarcan en su estructura el polimorfismo de diferentes cepas, y al ensayarse como vacunas inducen una respuesta de anticuerpos de mayor capacidad protectora y de mayor actividad opsonofagocítica. Las variantes ingenierizadas de pertactina de esta invención son aplicables en la medicina humana y veterinaria.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20070240A CU23679A1 (es) | 2007-10-30 | 2007-10-30 | Variantes de pertactinas para uso vacunal |
EP08845509A EP2216045A1 (en) | 2007-10-30 | 2008-10-17 | Engineered pertactin variants for vaccine use |
BRPI0817898 BRPI0817898A2 (pt) | 2007-10-30 | 2008-10-17 | Sequência polinucleotídica, composição farmacêutica, vacina, vetor de expressão em mamíferos, vacina, método para a deteccção de infecção por bordetella, e, kit diagnóstico para a detecção de presença ou ausência de anticorpos contra bordetella |
MX2010004706A MX2010004706A (es) | 2007-10-30 | 2008-10-17 | Variantes ingenierizadas de pertactina para uso vacunal. |
RU2010121646/10A RU2499046C2 (ru) | 2007-10-30 | 2008-10-17 | Полинуклеотидная последовательность, кодирующая сконструированный белок пертактин, вектор, включающий такую последовательность, и вакцинные композиции, содержащие белок пертактина или вектор |
PCT/CU2008/000009 WO2009056076A1 (es) | 2007-10-30 | 2008-10-17 | Variantes ingenierizadas de pertactina para uso vacunal |
CN2008801141194A CN101878038B (zh) | 2007-10-30 | 2008-10-17 | 用于疫苗用途的经改造的百日咳杆菌粘附素变体 |
CA2702697A CA2702697A1 (en) | 2007-10-30 | 2008-10-17 | Engineered pertactin variants for vaccine use |
US12/739,658 US8569470B2 (en) | 2007-10-30 | 2008-10-17 | Engineered pertactin variants for vaccine use |
KR1020107011928A KR20100093548A (ko) | 2007-10-30 | 2008-10-17 | 백신 용도의 유전자 조작된 퍼탁틴 변이체 |
ARP080104709A AR069086A1 (es) | 2007-10-30 | 2008-10-28 | Variantes ingenierizadas de pertactina para uso vacunal |
US13/966,948 US20140011216A1 (en) | 2007-10-30 | 2013-08-14 | Engineered pertactin variants for vaccine use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20070240A CU23679A1 (es) | 2007-10-30 | 2007-10-30 | Variantes de pertactinas para uso vacunal |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23679A1 true CU23679A1 (es) | 2011-07-11 |
Family
ID=40473455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20070240A CU23679A1 (es) | 2007-10-30 | 2007-10-30 | Variantes de pertactinas para uso vacunal |
Country Status (11)
Country | Link |
---|---|
US (2) | US8569470B2 (es) |
EP (1) | EP2216045A1 (es) |
KR (1) | KR20100093548A (es) |
CN (1) | CN101878038B (es) |
AR (1) | AR069086A1 (es) |
BR (1) | BRPI0817898A2 (es) |
CA (1) | CA2702697A1 (es) |
CU (1) | CU23679A1 (es) |
MX (1) | MX2010004706A (es) |
RU (1) | RU2499046C2 (es) |
WO (1) | WO2009056076A1 (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003533990A (ja) * | 2000-05-25 | 2003-11-18 | インスティチュート・パスツール | 百日咳菌、パラ百日咳菌および気管支敗血症菌のペルタクチンの繰返し領域の多型性を有するポリペプチド、ならびに診断および免疫原性組成物におけるその使用 |
EP1174505A1 (en) | 2000-06-30 | 2002-01-23 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | (Poly)peptides for the preparation of vaccines against Bordetella pertussis and/or Bordetella parapertussis, vaccines based upon such (poly)peptides, and antibodies against such peptides |
WO2005032584A2 (en) * | 2003-10-02 | 2005-04-14 | Glaxosmithkline Biologicals S.A. | Pertussis antigens and use thereof in vaccination |
UA40596U (ru) * | 2006-05-16 | 2009-04-27 | Институт Проблем Безопасности Атомных Электростанций Национальной Академии Наук Украины | Энергоблок атомной электростанции |
-
2007
- 2007-10-30 CU CU20070240A patent/CU23679A1/es not_active IP Right Cessation
-
2008
- 2008-10-17 RU RU2010121646/10A patent/RU2499046C2/ru not_active IP Right Cessation
- 2008-10-17 CN CN2008801141194A patent/CN101878038B/zh not_active Expired - Fee Related
- 2008-10-17 WO PCT/CU2008/000009 patent/WO2009056076A1/es active Application Filing
- 2008-10-17 MX MX2010004706A patent/MX2010004706A/es active IP Right Grant
- 2008-10-17 KR KR1020107011928A patent/KR20100093548A/ko not_active Application Discontinuation
- 2008-10-17 CA CA2702697A patent/CA2702697A1/en not_active Abandoned
- 2008-10-17 BR BRPI0817898 patent/BRPI0817898A2/pt not_active IP Right Cessation
- 2008-10-17 US US12/739,658 patent/US8569470B2/en not_active Expired - Fee Related
- 2008-10-17 EP EP08845509A patent/EP2216045A1/en not_active Withdrawn
- 2008-10-28 AR ARP080104709A patent/AR069086A1/es unknown
-
2013
- 2013-08-14 US US13/966,948 patent/US20140011216A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2010121646A (ru) | 2011-12-10 |
BRPI0817898A2 (pt) | 2015-05-05 |
RU2499046C2 (ru) | 2013-11-20 |
CN101878038A (zh) | 2010-11-03 |
AR069086A1 (es) | 2009-12-30 |
WO2009056076A1 (es) | 2009-05-07 |
MX2010004706A (es) | 2010-05-27 |
US20140011216A1 (en) | 2014-01-09 |
CN101878038B (zh) | 2013-11-06 |
US8569470B2 (en) | 2013-10-29 |
CA2702697A1 (en) | 2009-05-07 |
KR20100093548A (ko) | 2010-08-25 |
EP2216045A1 (en) | 2010-08-11 |
US20110070265A1 (en) | 2011-03-24 |
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Legal Events
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