CU20170105A7 - Derivados de nucleosidos sustituidos útiles como agentes antineoplásicos - Google Patents

Derivados de nucleosidos sustituidos útiles como agentes antineoplásicos

Info

Publication number
CU20170105A7
CU20170105A7 CUP2017000105A CU20170105A CU20170105A7 CU 20170105 A7 CU20170105 A7 CU 20170105A7 CU P2017000105 A CUP2017000105 A CU P2017000105A CU 20170105 A CU20170105 A CU 20170105A CU 20170105 A7 CU20170105 A7 CU 20170105A7
Authority
CU
Cuba
Prior art keywords
nucleosids
derivatives
antineoplastic agents
replaced
useful
Prior art date
Application number
CUP2017000105A
Other languages
English (en)
Inventor
Robert Arnold Kumpf
Indrawan James Mcalpine
Michele Ann Mctigue
Eugene Yuanjin Rui
John Howard Tatlock
Michelle Bich Tran-Dube
Martin James Wythes
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20170105A7 publication Critical patent/CU20170105A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Abstract

<p>Los compuestos de Ia Fórmula general (1):</p> <p>ESPACIO PARA FÓRMULA</p> <p>procesos para Ia preparación de estos compuestos, composiciones que contienen estos compuestos y los usos de estos compuestos.<br />  </p>
CUP2017000105A 2015-02-24 2016-02-15 Derivados de nucleosidos sustituidos útiles como agentes antineoplásicos CU20170105A7 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562119932P 2015-02-24 2015-02-24
US201562213801P 2015-09-03 2015-09-03
US201662279209P 2016-01-15 2016-01-15
PCT/IB2016/050803 WO2016135582A1 (en) 2015-02-24 2016-02-15 Substituted nucleoside derivatives useful as anticancer agents

Publications (1)

Publication Number Publication Date
CU20170105A7 true CU20170105A7 (es) 2017-10-05

Family

ID=55451515

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2017000105A CU20170105A7 (es) 2015-02-24 2016-02-15 Derivados de nucleosidos sustituidos útiles como agentes antineoplásicos

Country Status (29)

Country Link
US (1) US10428104B2 (es)
EP (1) EP3262057B1 (es)
JP (1) JP6584521B2 (es)
KR (1) KR20170119705A (es)
CN (1) CN107278205A (es)
AU (2) AU2016225133B2 (es)
BR (1) BR112017017396A2 (es)
CA (1) CA2921314A1 (es)
CL (1) CL2017002155A1 (es)
CO (1) CO2017008403A2 (es)
CR (1) CR20170384A (es)
CU (1) CU20170105A7 (es)
DO (1) DOP2017000195A (es)
EA (1) EA031895B1 (es)
ES (1) ES2792899T3 (es)
GT (1) GT201700189A (es)
IL (1) IL253637A0 (es)
MX (1) MX2017010844A (es)
NI (1) NI201700095A (es)
PE (1) PE20171449A1 (es)
PH (1) PH12017501413A1 (es)
SG (1) SG11201706050WA (es)
SV (1) SV2017005514A (es)
TN (1) TN2017000357A1 (es)
TW (1) TWI622595B (es)
UA (1) UA118315C2 (es)
UY (1) UY36564A (es)
WO (1) WO2016135582A1 (es)
ZA (1) ZA201705092B (es)

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US20210309687A1 (en) * 2018-08-07 2021-10-07 Merck Sharp & Dohme Corp. Prmt5 inhibitors
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EP3947387A4 (en) * 2019-03-25 2022-11-30 California Institute Of Technology PRMT5 INHIBITORS AND USES THEREOF
TW202112375A (zh) 2019-06-06 2021-04-01 比利時商健生藥品公司 使用ｐｒｍｔ５抑制劑治療癌症之方法
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CA3156135A1 (en) 2019-10-22 2021-04-29 Lupin Limited PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITORS
US20230066014A1 (en) 2019-12-03 2023-03-02 Lupin Limited Substituted nucleoside analogs as prmt5 inhibitors
JP2023538614A (ja) 2020-08-18 2023-09-08 インサイト・コーポレイション Ｊａｋ１阻害剤を調製するためのプロセス及び中間体
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Also Published As

Publication number Publication date
BR112017017396A2 (pt) 2018-04-03
UY36564A (es) 2016-09-30
DOP2017000195A (es) 2017-10-15
EA201791563A1 (ru) 2018-01-31
PE20171449A1 (es) 2017-10-02
AU2018278842A1 (en) 2019-01-03
TW201643176A (zh) 2016-12-16
CO2017008403A2 (es) 2017-10-31
TN2017000357A1 (en) 2019-01-16
PH12017501413A1 (en) 2018-01-29
EA031895B1 (ru) 2019-03-29
CN107278205A (zh) 2017-10-20
GT201700189A (es) 2019-06-10
EP3262057A1 (en) 2018-01-03
AU2016225133A1 (en) 2017-08-10
IL253637A0 (en) 2017-09-28
SG11201706050WA (en) 2017-09-28
NI201700095A (es) 2017-10-31
ZA201705092B (en) 2019-06-26
EP3262057B1 (en) 2020-04-15
CL2017002155A1 (es) 2018-05-11
US10428104B2 (en) 2019-10-01
UA118315C2 (uk) 2018-12-26
JP6584521B2 (ja) 2019-10-02
ES2792899T3 (es) 2020-11-12
WO2016135582A1 (en) 2016-09-01
US20160244475A1 (en) 2016-08-25
AU2016225133B2 (en) 2018-11-29
KR20170119705A (ko) 2017-10-27
CA2921314A1 (en) 2016-08-24
SV2017005514A (es) 2018-04-11
TWI622595B (zh) 2018-05-01
JP2018510850A (ja) 2018-04-19
CR20170384A (es) 2017-11-16
MX2017010844A (es) 2017-12-07

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