CU20150165A7 - Proceso para la preparación de (2r,3r)-3-{[ 2-}[4-(s-ciclopropilsulfonimidoil)fenil]amino{ -5-(trifluorometil)pirimidin-4-il]oxi}butan-2-ol - Google Patents

Proceso para la preparación de (2r,3r)-3-{[ 2-}[4-(s-ciclopropilsulfonimidoil)fenil]amino{ -5-(trifluorometil)pirimidin-4-il]oxi}butan-2-ol

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Publication number
CU20150165A7
CU20150165A7 CUP2015000165A CU20150165A CU20150165A7 CU 20150165 A7 CU20150165 A7 CU 20150165A7 CU P2015000165 A CUP2015000165 A CU P2015000165A CU 20150165 A CU20150165 A CU 20150165A CU 20150165 A7 CU20150165 A7 CU 20150165A7
Authority
CU
Cuba
Prior art keywords
preparation
cyclopropilsulfonimidoil
trifluorometil
pirimidin
oxi
Prior art date
Application number
CUP2015000165A
Other languages
English (en)
Inventor
Joachim Krüger
Jörg Gries
Kai Lovis
Jorma Hassfeld
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44677881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20150165(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CU20150165A7 publication Critical patent/CU20150165A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La invención provee un nuevo proceso para la preparación deinhibidores de pan-CDK de la fórmula (I) ESPACIO PARA LA FÓRMULA que comprende pasos de alquilación, aminación oxidativa, oxidación, desprotección, separación de racemato, hidrogenación, preparación en dos etapas, acoplamiento, preparación de sales doblemente protegidas y separación de grupos protectores por hidrogenación y también por tratamiento con carbonato de potasio en metanol.
CUP2015000165A 2010-09-23 2015-11-30 Proceso para la preparación de (2r,3r)-3-{[ 2-}[4-(s-ciclopropilsulfonimidoil)fenil]amino{ -5-(trifluorometil)pirimidin-4-il]oxi}butan-2-ol CU20150165A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010046720A DE102010046720A1 (de) 2010-09-23 2010-09-23 Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung
PCT/EP2011/066295 WO2012038411A1 (de) 2010-09-23 2011-09-20 Verfahren zur herstellung von pan-cdk-inhibitoren der formel (i), sowie intermediate der herstellung

Publications (1)

Publication Number Publication Date
CU20150165A7 true CU20150165A7 (es) 2016-05-30

Family

ID=44677881

Family Applications (2)

Application Number Title Priority Date Filing Date
CU2013000044A CU20130044A7 (es) 2010-09-23 2013-03-22 Proceso para la preparación de inhibidores de pan-cdk de fórmula (i), e intermediarios de la preparación
CUP2015000165A CU20150165A7 (es) 2010-09-23 2015-11-30 Proceso para la preparación de (2r,3r)-3-{[ 2-}[4-(s-ciclopropilsulfonimidoil)fenil]amino{ -5-(trifluorometil)pirimidin-4-il]oxi}butan-2-ol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CU2013000044A CU20130044A7 (es) 2010-09-23 2013-03-22 Proceso para la preparación de inhibidores de pan-cdk de fórmula (i), e intermediarios de la preparación

Country Status (32)

Country Link
US (1) US9359306B2 (es)
EP (1) EP2619186A1 (es)
JP (1) JP5969993B2 (es)
KR (1) KR20130109145A (es)
CN (1) CN103119026B (es)
AP (1) AP2013006816A0 (es)
AR (1) AR083171A1 (es)
AU (1) AU2011304365B2 (es)
BR (1) BR112013006720A2 (es)
CA (1) CA2811807A1 (es)
CL (1) CL2013000797A1 (es)
CO (1) CO6690779A2 (es)
CR (1) CR20130138A (es)
CU (2) CU20130044A7 (es)
DE (1) DE102010046720A1 (es)
DO (1) DOP2013000063A (es)
EC (1) ECSP13012520A (es)
GT (1) GT201300078A (es)
HK (1) HK1185615A1 (es)
IL (1) IL225352A0 (es)
MX (1) MX2013003338A (es)
MY (1) MY160625A (es)
NZ (1) NZ608448A (es)
PE (1) PE20140182A1 (es)
RU (1) RU2585621C2 (es)
SA (1) SA111320775B1 (es)
SG (1) SG188967A1 (es)
TW (1) TWI530488B (es)
UA (1) UA110626C2 (es)
UY (1) UY33624A (es)
WO (1) WO2012038411A1 (es)
ZA (1) ZA201301799B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之ｎ－（吡啶－２－基）嘧啶－４－胺衍生物
WO2014173815A1 (en) * 2013-04-23 2014-10-30 Bayer Pharma Aktiengesellschaft Use of (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5- (trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide for the treatment of specific tumours
AR113344A1 (es) 2017-10-05 2020-04-22 Innovative Molecules Gmbh Enantiómeros de una serie de compuestos antivirales
AU2019221019B2 (en) 2018-02-13 2024-05-02 Bayer Ag Use of 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large B-cell lymphoma

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA964426B (en) * 1995-06-05 1997-03-06 Rhone Poulenc Agrochimie Pesticidal sulfur compounds
EP1291336A3 (en) 2001-09-05 2003-10-08 Solvias AG Preparation of optically active alpha-hydroxyethers
DE10349423A1 (de) * 2003-10-16 2005-06-16 Schering Ag Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
DE102005062742A1 (de) * 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
EP2022785A1 (en) * 2007-06-20 2009-02-11 Bayer Schering Pharma Aktiengesellschaft Alkynylpyrimidines as Tie2 kinase inhibitors
EP2179991A1 (de) 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel

Also Published As

Publication number Publication date
ECSP13012520A (es) 2013-05-31
ZA201301799B (en) 2014-05-28
DE102010046720A1 (de) 2012-03-29
AR083171A1 (es) 2013-02-06
UA110626C2 (uk) 2016-01-25
CO6690779A2 (es) 2013-06-17
SA111320775B1 (ar) 2015-02-03
SG188967A1 (en) 2013-05-31
IL225352A0 (en) 2013-06-27
CN103119026A (zh) 2013-05-22
TW201215596A (en) 2012-04-16
GT201300078A (es) 2014-11-26
CR20130138A (es) 2013-05-15
CU20130044A7 (es) 2013-07-31
MY160625A (en) 2017-03-15
WO2012038411A1 (de) 2012-03-29
RU2013118432A (ru) 2014-10-27
KR20130109145A (ko) 2013-10-07
RU2585621C2 (ru) 2016-05-27
TWI530488B (zh) 2016-04-21
EP2619186A1 (de) 2013-07-31
JP5969993B2 (ja) 2016-08-17
DOP2013000063A (es) 2013-04-30
BR112013006720A2 (pt) 2016-06-14
US9359306B2 (en) 2016-06-07
AU2011304365B2 (en) 2015-02-05
AU2011304365A1 (en) 2013-04-11
MX2013003338A (es) 2013-06-24
NZ608448A (en) 2014-10-31
HK1185615A1 (en) 2014-02-21
US20130245261A1 (en) 2013-09-19
PE20140182A1 (es) 2014-02-14
AP2013006816A0 (en) 2013-04-30
JP2013542189A (ja) 2013-11-21
CN103119026B (zh) 2015-08-19
CA2811807A1 (en) 2012-03-29
CL2013000797A1 (es) 2013-09-13
UY33624A (es) 2012-04-30

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