CU20150042A7 - Método de preparación de compuestos alfa-galactosil ceramidas - Google Patents

Método de preparación de compuestos alfa-galactosil ceramidas

Info

Publication number
CU20150042A7
CU20150042A7 CUP2015000042A CU20150042A CU20150042A7 CU 20150042 A7 CU20150042 A7 CU 20150042A7 CU P2015000042 A CUP2015000042 A CU P2015000042A CU 20150042 A CU20150042 A CU 20150042A CU 20150042 A7 CU20150042 A7 CU 20150042A7
Authority
CU
Cuba
Prior art keywords
galactosil
alfa
preparation
formula
compounds
Prior art date
Application number
CUP2015000042A
Other languages
English (en)
Other versions
CU24311B1 (es
Inventor
Vincet Serra
Original Assignee
Abivax
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abivax filed Critical Abivax
Publication of CU20150042A7 publication Critical patent/CU20150042A7/es
Publication of CU24311B1 publication Critical patent/CU24311B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se relaciona con un método de preparación de compuestos alfa-galactosilceramidas de la fórmula (I): ESPACIO PARA FÓRMULA que comprende un paso a) de glicosilación de un compuesto de la fórmula (II): ESPACIO PARA FÓRMULA con un compuesto de la fórmula (III): ESPACIO PARA FÓRMULA
CUP2015000042A 2012-10-30 2013-10-30 Método de preparación de compuestos alfa-galactosil ceramidas CU24311B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261720098P 2012-10-30 2012-10-30
EP12306355.4A EP2727929A1 (en) 2012-10-30 2012-10-30 Method of preparation of alpha galactosyl ceramides compounds
PCT/EP2013/072711 WO2014067995A1 (en) 2012-10-30 2013-10-30 METHOD OF PREPARATION OF α-GALACTOSYL CERAMIDES COMPOUNDS

Publications (2)

Publication Number Publication Date
CU20150042A7 true CU20150042A7 (es) 2016-04-25
CU24311B1 CU24311B1 (es) 2018-01-10

Family

ID=47172560

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2015000042A CU24311B1 (es) 2012-10-30 2013-10-30 Método de preparación de compuestos alfa-galactosil ceramidas

Country Status (23)

Country Link
US (1) US10870671B2 (es)
EP (2) EP2727929A1 (es)
JP (1) JP6140830B2 (es)
CN (2) CN109503682B (es)
AR (1) AR093270A1 (es)
AU (1) AU2013340901B2 (es)
BR (1) BR112015009720B1 (es)
CA (1) CA2888391C (es)
CU (1) CU24311B1 (es)
CY (1) CY1119697T1 (es)
DK (1) DK2920194T3 (es)
ES (1) ES2655655T3 (es)
HR (1) HRP20171687T1 (es)
HU (1) HUE035530T2 (es)
IL (1) IL238515B (es)
LT (1) LT2920194T (es)
MX (1) MX363944B (es)
PL (1) PL2920194T3 (es)
PT (1) PT2920194T (es)
RU (1) RU2662156C2 (es)
SI (1) SI2920194T1 (es)
WO (1) WO2014067995A1 (es)
ZA (1) ZA201502844B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3102486A1 (en) * 2018-06-15 2019-12-19 Carbocode S.A. Glycosylated sphingoid bases and production thereof
CN110479184B (zh) * 2019-08-05 2021-09-07 华侨大学 一种琼脂糖基乳化剂及其制备方法和应用
AU2022228420A1 (en) 2021-03-01 2023-10-05 Deciduous Therapeutics, Inc. Compounds for activating invariant natural killer t-cells and methods of use in eliminating inflammatory senescent cells
WO2024050020A1 (en) * 2022-08-31 2024-03-07 Deciduous Therapeutics, Inc. Invariant natural killer t-cell activators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758395A (fr) * 1969-11-03 1971-05-03 Upjohn Co Procede de conversion d'halogenures de cis-glucosyle peracyles et nouveaux composes en derivant
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
FR2711138B1 (fr) 1993-10-12 1995-11-24 Oreal Céramides, leur procédé de préparation et leurs applications en cosmétique et en dermopharmacie.
CN1405172A (zh) 2001-08-13 2003-03-26 青岛海洋大学 一种乳糖胺脂及其制备方法和应用
CA2626997C (en) * 2005-10-25 2014-12-23 Ludwig Institute For Cancer Research Analogs of alpha galactosylceramide and uses thereof
US8227581B2 (en) 2006-04-07 2012-07-24 The Scripps Research Institute Modified α-galactosyl ceramides for staining and stimulating natural killer T cells
CN101012254A (zh) 2006-08-29 2007-08-08 中国海洋大学 一种α－半乳糖鞘糖脂的2’－OH衍生物及其制备方法
BR112013017382B1 (pt) * 2011-01-05 2021-03-16 National Taiwan University método de preparação de um composto de fórmula (5)

Also Published As

Publication number Publication date
BR112015009720A2 (pt) 2017-07-04
PL2920194T3 (pl) 2018-03-30
US20150291646A1 (en) 2015-10-15
MX2015005592A (es) 2016-06-02
CY1119697T1 (el) 2018-04-04
JP6140830B2 (ja) 2017-05-31
DK2920194T3 (en) 2017-12-04
EP2727929A1 (en) 2014-05-07
CN109503682B (zh) 2023-07-07
CN109503682A (zh) 2019-03-22
ZA201502844B (en) 2016-09-28
AU2013340901A2 (en) 2015-05-14
WO2014067995A1 (en) 2014-05-08
IL238515A0 (en) 2015-06-30
JP2016500056A (ja) 2016-01-07
IL238515B (en) 2018-05-31
RU2015116422A (ru) 2016-11-20
AU2013340901B2 (en) 2017-08-10
CN104812769A (zh) 2015-07-29
US10870671B2 (en) 2020-12-22
CU24311B1 (es) 2018-01-10
RU2662156C2 (ru) 2018-07-24
HRP20171687T1 (hr) 2017-12-15
LT2920194T (lt) 2017-12-27
EP2920194B1 (en) 2017-10-11
EP2920194A1 (en) 2015-09-23
AU2013340901A1 (en) 2015-04-30
CA2888391A1 (en) 2014-05-08
PT2920194T (pt) 2018-01-09
CA2888391C (en) 2020-07-28
MX363944B (es) 2019-04-09
HUE035530T2 (en) 2018-05-02
BR112015009720B1 (pt) 2022-06-14
AR093270A1 (es) 2015-05-27
SI2920194T1 (en) 2018-02-28
ES2655655T3 (es) 2018-02-21

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