CS748988A2 - Method of quinolone derivatives production - Google Patents

Method of quinolone derivatives production

Info

Publication number
CS748988A2
CS748988A2 CS887489A CS748988A CS748988A2 CS 748988 A2 CS748988 A2 CS 748988A2 CS 887489 A CS887489 A CS 887489A CS 748988 A CS748988 A CS 748988A CS 748988 A2 CS748988 A2 CS 748988A2
Authority
CS
Czechoslovakia
Prior art keywords
quinolone derivatives
formula
compounds
derivatives production
cyclisation
Prior art date
Application number
CS887489A
Other languages
English (en)
Other versions
CS274487B2 (en
Inventor
Lachlan Maclean
David L Roberts
Kenneth Barron
Kenneth J Nichol
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Priority to CS236489A priority Critical patent/CS274499B2/cs
Publication of CS748988A2 publication Critical patent/CS748988A2/cs
Publication of CS274487B2 publication Critical patent/CS274487B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CS748988A 1987-11-18 1988-11-15 Method of quinolone derivatives production CS274487B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS236489A CS274499B2 (en) 1987-11-18 1989-04-17 Method of 7-fluor-1-methyl-3-methylthio-4-quinolone production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878726950A GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process

Publications (2)

Publication Number Publication Date
CS748988A2 true CS748988A2 (en) 1990-09-12
CS274487B2 CS274487B2 (en) 1991-04-11

Family

ID=10627131

Family Applications (1)

Application Number Title Priority Date Filing Date
CS748988A CS274487B2 (en) 1987-11-18 1988-11-15 Method of quinolone derivatives production

Country Status (28)

Country Link
US (2) US5011931A (cs)
EP (2) EP0317149B1 (cs)
JP (1) JPH02502013A (cs)
KR (1) KR890701563A (cs)
AT (1) ATE69221T1 (cs)
AU (1) AU628305B2 (cs)
BG (1) BG50157A3 (cs)
CS (1) CS274487B2 (cs)
DD (1) DD290188A5 (cs)
DE (1) DE3866086D1 (cs)
ES (1) ES2038310T3 (cs)
FI (1) FI91063C (cs)
GB (1) GB8726950D0 (cs)
GR (1) GR3003378T3 (cs)
HU (1) HU204511B (cs)
IE (1) IE883366L (cs)
IL (1) IL88358A (cs)
MX (1) MX168918B (cs)
NZ (1) NZ227008A (cs)
PH (1) PH27439A (cs)
PL (1) PL157191B1 (cs)
PT (1) PT89024B (cs)
RO (1) RO104615B1 (cs)
SU (1) SU1766255A3 (cs)
TW (1) TW204344B (cs)
WO (1) WO1989004827A1 (cs)
YU (1) YU46989B (cs)
ZA (1) ZA888241B (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132753A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6110489A (en) * 1998-05-01 2000-08-29 Cutler; Neal R. Use of quinolines and quinolones to treat male erectile dysfunction
US6194433B1 (en) 1998-10-05 2001-02-27 Neal R. Cutler Sexual dysfunction in females
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6303135B1 (en) 1999-07-08 2001-10-16 Neal R. Cutler Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6649764B2 (en) 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
CN102316902B (zh) 2009-02-20 2014-09-24 to-BBB控股股份有限公司 基于谷胱甘肽的药物递送系统
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920699A (en) * 1974-04-26 1975-11-18 Warner Lambert Co Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) * 1976-11-25 1980-03-11 Ciba-Geigy Corporation Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
DE3578374D1 (de) * 1984-01-13 1990-08-02 Boots Co Ltd Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen.
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process

Also Published As

Publication number Publication date
ZA888241B (en) 1989-10-25
FI893405L (fi) 1989-07-13
JPH02502013A (ja) 1990-07-05
RO104615B1 (en) 1992-11-03
HUT53085A (en) 1990-09-28
EP0317149A1 (en) 1989-05-24
DE3866086D1 (de) 1991-12-12
EP0343206A1 (en) 1989-11-29
KR890701563A (ko) 1989-12-21
FI91063C (fi) 1994-05-10
IE883366L (en) 1989-05-18
WO1989004827A1 (en) 1989-06-01
HU204511B (en) 1992-01-28
PT89024B (pt) 1993-02-26
PL275880A1 (en) 1989-06-12
ATE69221T1 (de) 1991-11-15
TW204344B (cs) 1993-04-21
PH27439A (en) 1993-07-02
SU1766255A3 (ru) 1992-09-30
US5079264A (en) 1992-01-07
FI893405A0 (fi) 1989-07-13
US5011931A (en) 1991-04-30
EP0317149B1 (en) 1991-11-06
BG50157A3 (bg) 1992-05-15
MX168918B (es) 1993-06-14
NZ227008A (en) 1991-10-25
IL88358A0 (en) 1989-06-30
PT89024A (pt) 1988-12-01
YU46989B (sh) 1994-09-09
GB8726950D0 (en) 1987-12-23
AU2616388A (en) 1989-06-14
ES2038310T3 (es) 1993-07-16
FI91063B (fi) 1994-01-31
DD290188A5 (de) 1991-05-23
YU209788A (en) 1990-08-31
GR3003378T3 (en) 1993-02-17
AU628305B2 (en) 1992-09-17
PL157191B1 (pl) 1992-05-29
IL88358A (en) 1993-02-21
CS274487B2 (en) 1991-04-11

Similar Documents

Publication Publication Date Title
CS748988A2 (en) Method of quinolone derivatives production
NO955023L (no) Piperidinderivater og fremgangsmåte for fremstilling derav
GR3004139T3 (cs)
ES2093013T3 (es) Derivados de alcoxiiminoacetamida y su aplicacion como fungicidas.
NO902301D0 (no) Fremgangsmaate for fremstilling av diarylstyrylkinolin-disyrer.
DK0503453T3 (da) Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde
ATE58532T1 (de) (2-amino-4-aryl-thiazol-5-yl)aethanol, und deren derivate mit diuretischer aktivitaet und verfahren zu deren herstellung.
NO842014L (no) Fremgangsmaate til fremstilling av beta-karbolin-3-karboksylsyrederivater
SE8602523L (sv) 2-alkyl- eller -aralkyltio-1-cykloalken-1-karboxamider och deras sulfoxider, sett for deras framstellning och deras anvendning for syntes av tri- och 4,5-tetrametylen-4-isotiazolin-3-oner
NO892973D0 (no) Fremgangsmaate for fremstilling av substituerte guanyltiourinstoff-forbindelser.
HUT34316A (en) Process for producing heterocyclic hydroximidates and thiohydroximidates and their carbamate-ester derivatives
DK46884D0 (da) 5-aminomethyl-imidazol-1-yl-1,3-dialkyl-1h-pyrazol-4-yl-aroyl-methanoner,fremgangsmaade til deres fremstilling samt deres anvendelse
DE60014556D1 (de) Verfahren zur Herstellung von (S)-N-tertbutyl-1,2,3,4- Tetrahydroisochinolin-3-carboxamid