CS622779A2 - Zpusob vyroby 9 (hydroxyalkyl) hypoxanthinu - Google Patents

Zpusob vyroby 9 (hydroxyalkyl) hypoxanthinu

Info

Publication number
CS622779A2
CS622779A2 CS796227A CS622779A CS622779A2 CS 622779 A2 CS622779 A2 CS 622779A2 CS 796227 A CS796227 A CS 796227A CS 622779 A CS622779 A CS 622779A CS 622779 A2 CS622779 A2 CS 622779A2
Authority
CS
Czechoslovakia
Prior art keywords
hypoxanthinu
hydroxyalkyl
zpusob vyroby
vyroby
zpusob
Prior art date
Application number
CS796227A
Other languages
English (en)
Other versions
CS241023B2 (en
Inventor
Sorolla Alfredo Giner
Original Assignee
Newport Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newport Pharmaceuticals filed Critical Newport Pharmaceuticals
Publication of CS622779A2 publication Critical patent/CS622779A2/cs
Publication of CS241023B2 publication Critical patent/CS241023B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS796227A 1978-09-15 1979-09-14 Method of 9-(hydroxylakyl)-hypoxanthines production CS241023B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/942,804 US4221910A (en) 1978-09-15 1978-09-15 9-(Hydroxy alkyl)purines

Publications (2)

Publication Number Publication Date
CS622779A2 true CS622779A2 (en) 1985-06-13
CS241023B2 CS241023B2 (en) 1986-03-13

Family

ID=25478624

Family Applications (1)

Application Number Title Priority Date Filing Date
CS796227A CS241023B2 (en) 1978-09-15 1979-09-14 Method of 9-(hydroxylakyl)-hypoxanthines production

Country Status (26)

Country Link
US (1) US4221910A (cs)
EP (1) EP0009155B1 (cs)
JP (1) JPS5559188A (cs)
AT (1) ATE1814T1 (cs)
AU (1) AU527881B2 (cs)
CA (1) CA1121818A (cs)
CS (1) CS241023B2 (cs)
DD (1) DD146050A5 (cs)
DE (1) DE2964059D1 (cs)
DK (1) DK145627C (cs)
ES (1) ES484168A1 (cs)
FI (1) FI67847C (cs)
GR (1) GR72523B (cs)
HU (1) HU180892B (cs)
IE (1) IE48826B1 (cs)
IL (1) IL58086A (cs)
IN (1) IN153050B (cs)
MX (1) MX6270E (cs)
NO (1) NO152446C (cs)
NZ (1) NZ191482A (cs)
PH (1) PH15921A (cs)
PL (2) PL124228B1 (cs)
PT (1) PT70179A (cs)
RO (1) RO77559A (cs)
YU (1) YU41885B (cs)
ZA (1) ZA793972B (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4340726A (en) * 1980-03-14 1982-07-20 Newport Pharmaceuticals International, Inc. Esters
US4457919A (en) * 1980-03-14 1984-07-03 Newport Pharmaceutical International, Inc. Method of imparting immunomodulating, antiviral or antitumor activity
US4388308A (en) * 1980-06-09 1983-06-14 G.D. Searle & Co. N6 -[(2-Hydroxypropyl)aryl]adenosines
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds
SE8203856D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine ii
SE8203855D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine i
JPS59135334A (ja) * 1983-01-24 1984-08-03 Kawasaki Steel Corp デジタル式張力測定装置
IT1213495B (it) * 1986-09-17 1989-12-20 Sigma Tau Ind Farmaceuti Processo per la preparazione dell'alfa-n-[(ipoxatin-9-il)pentilossicarbonil-]arginina
IT1215339B (it) * 1987-01-14 1990-02-08 Co Pharma Corp Srl Procedimento per la preparazione di 9-(idrossialchil)-ipoxantine
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
US5091432A (en) * 1990-03-28 1992-02-25 Glasky Alvin J 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5801184A (en) * 1994-07-25 1998-09-01 Glasky; Alvin J. Carbon monoxide dependent guanylyl cyclase modifiers and methods of use
US5447939A (en) * 1994-07-25 1995-09-05 Glasky; Alvin J. Carbon monoxide dependent guanylyl cyclase modifiers and methods of use
JPH10504814A (ja) * 1994-07-25 1998-05-12 ジェイ． グラスキー，アルヴィン 一酸化炭素依存性グアニリルシクラーゼ修飾因子
AU3786299A (en) 1998-05-04 1999-11-23 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
US6297226B1 (en) 1999-10-15 2001-10-02 Neotherapeutics, Inc. Synthesis and methods of use of 9-substituted guanine derivatives
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
DK1790344T3 (da) 2000-07-07 2011-05-02 Spectrum Pharmaceuticals Inc Fremgangsmåder til behandling af sygdomsfremkaldt perifer neuropati og beslægtede tilstande
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
CA2540598C (en) * 2003-10-03 2013-09-24 3M Innovative Properties Company Pyrazolopyridines and analogs thereof
WO2005074946A1 (en) * 2004-02-10 2005-08-18 Adenobio N.V. Stable and active complexes of adenosine and adenosine phosphates with aminoalcohols for the treatment of pulmonary artery hypertension, cardiac failure and other diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH443312A (fr) * 1963-10-29 1967-09-15 Ajinomoto Kk Procédé de préparation du 1-N-oxyde d'hypoxanthine et du 1-N-oxyde d'inosine substituée ou non, et utilisation des produits obtenus par ce procédé poutilisation des produits obtenus par ce procédé pour la préparation de la 2,6-dichloro-purine et 9-B-D-ribofuranosyl purine substitua ée ou non
DE1911279A1 (de) * 1969-03-05 1970-11-12 Eckert Dr Theodor Verfahren zur Erhoehung der Resorptionsfaehigkeit von Arzneistoffen
US3813394A (en) * 1969-08-18 1974-05-28 Fujisawa Pharmaceutical Co Purine derivatives having hypocholesterolemic activity
JPS504012A (cs) * 1972-12-16 1975-01-16
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
US4031218A (en) * 1976-04-28 1977-06-21 Mallinckrodt, Inc. 7-(2,3-Dihydroxypropyl-1,3-di-n-propylxanthine and a pharmaceutical composition containing same useful as a bronchial muscle relaxant

Also Published As

Publication number Publication date
DK145627C (da) 1983-06-20
FI792848A (fi) 1980-03-16
JPS5559188A (en) 1980-05-02
PL124228B1 (en) 1983-01-31
EP0009155A1 (en) 1980-04-02
PT70179A (en) 1979-10-01
ZA793972B (en) 1980-09-24
US4221910A (en) 1980-09-09
DE2964059D1 (en) 1982-12-23
NO792791L (no) 1980-03-18
DK385579A (da) 1980-03-16
IL58086A (en) 1982-04-30
PH15921A (en) 1983-04-22
PL124177B1 (en) 1982-12-31
ES484168A1 (es) 1980-09-01
AU5055679A (en) 1980-03-20
HU180892B (en) 1983-05-30
MX6270E (es) 1985-02-27
CS241023B2 (en) 1986-03-13
DK145627B (da) 1983-01-03
YU224679A (en) 1984-06-30
AU527881B2 (en) 1983-03-31
YU41885B (en) 1988-02-29
IE791752L (en) 1980-03-15
FI67847B (fi) 1985-02-28
PL218318A1 (cs) 1980-06-16
NZ191482A (en) 1984-04-27
JPH031310B2 (cs) 1991-01-10
NO152446C (no) 1985-10-02
CA1121818A (en) 1982-04-13
ATE1814T1 (de) 1982-12-15
RO77559A (ro) 1982-02-01
IE48826B1 (en) 1985-05-29
GR72523B (cs) 1984-11-16
IL58086A0 (en) 1979-12-30
FI67847C (fi) 1985-06-10
IN153050B (cs) 1984-05-26
DD146050A5 (de) 1981-01-21
NO152446B (no) 1985-06-24
EP0009155B1 (en) 1982-11-17

Similar Documents

Publication Publication Date Title
CS622779A2 (en) Zpusob vyroby 9 (hydroxyalkyl) hypoxanthinu
ES464193A1 (es) Procedimiento para la preparacion de espirolactonas.
JPS5432460A (en) Cycloalkylidenemethylphenylacetic acid derivative and their preparation
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
DE3262905D1 (en) Chlorinated beta-ketoesters, their preparation and their use
DE3560110D1 (en) Derivatives of 2-alkoxyaminosulfonylbenzenesulfonylurea
IE791781L (en) 4, 5-methano-bufadienolide rhamnosides
GB2019843A (en) N-Alkenylmoranoline derivatives
DE3172309D1 (en) Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them
DE3160968D1 (en) Cardenolide-bis-digitoxoside derivatives, process for their preparation and their utilization as medicines
JPS5427578A (en) 1-carboxyalkylcarbamoyl-5-fluorouracil derivatives and their preparation
JPS5321170A (en) Preparation of branched 2-deoxy-alpha-glycosides
ES479478A1 (es) Procedimiento para preparar derivados del isocromano.
JPS5384935A (en) N-substitute benzanilides and bactericides containing the same
JPS5414961A (en) Novel 3-hydroxyazetidine-3-carboxylic derivative
JPS53124276A (en) Uracil derivatives
JPS5439080A (en) Isoquinolinoacetic acids
JPS5427560A (en) Novel imidazole derivatives
ES8407044A1 (es) "un procedimiento para preparar nuevos compuestos de urea"
JPS5414995A (en) Alpha-acylaminobenzylpenicillin