CS277375B6 - Matrica pre perkutánnu aplikáciu glyceroltrinitrátu transdermálnym terapeutickým systémom - Google Patents
Matrica pre perkutánnu aplikáciu glyceroltrinitrátu transdermálnym terapeutickým systémom Download PDFInfo
- Publication number
- CS277375B6 CS277375B6 CS911408A CS140891A CS277375B6 CS 277375 B6 CS277375 B6 CS 277375B6 CS 911408 A CS911408 A CS 911408A CS 140891 A CS140891 A CS 140891A CS 277375 B6 CS277375 B6 CS 277375B6
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- matrix
- drug
- glycerol trinitrate
- transdermal therapeutic
- release
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title claims description 30
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 title claims description 19
- 230000001225 therapeutic effect Effects 0.000 title claims description 17
- 229920001577 copolymer Polymers 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229920000249 biocompatible polymer Polymers 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 description 30
- 229940079593 drug Drugs 0.000 description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000002131 composite material Substances 0.000 description 2
- 238000013267 controlled drug release Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- NNKAHFKLYXCFDQ-UHFFFAOYSA-N [diethoxy(triethoxysilyloxy)silyl] diethyl triethoxysilyl silicate Chemical compound CCO[Si](OCC)(OCC)O[Si](OCC)(OCC)O[Si](OCC)(OCC)O[Si](OCC)(OCC)OCC NNKAHFKLYXCFDQ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- AYOHIQLKSOJJQH-UHFFFAOYSA-N dibutyltin Chemical compound CCCC[Sn]CCCC AYOHIQLKSOJJQH-UHFFFAOYSA-N 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940082615 organic nitrates used in cardiac disease Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS911408A CZ140891A3 (cs) | 1991-05-14 | 1991-05-14 | Matrica pre perkutánnu aplikáciu glyceroltrinítrátu transdermálnym terapeutickým systémem |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS911408A CZ140891A3 (cs) | 1991-05-14 | 1991-05-14 | Matrica pre perkutánnu aplikáciu glyceroltrinítrátu transdermálnym terapeutickým systémem |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS277375B6 true CS277375B6 (sk) | 1993-01-13 |
| CZ140891A3 CZ140891A3 (cs) | 1993-01-13 |
Family
ID=5348381
Country Status (1)
| Country | Link |
|---|---|
| CZ (1) | CZ140891A3 (sk) |
-
1991
- 1991-05-14 CZ CS911408A patent/CZ140891A3/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ140891A3 (cs) | 1993-01-13 |
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