CS248032B2 - Determination method of substances in liquids and aid to perform this method - Google Patents
Determination method of substances in liquids and aid to perform this method Download PDFInfo
- Publication number
- CS248032B2 CS248032B2 CS826525A CS652582A CS248032B2 CS 248032 B2 CS248032 B2 CS 248032B2 CS 826525 A CS826525 A CS 826525A CS 652582 A CS652582 A CS 652582A CS 248032 B2 CS248032 B2 CS 248032B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- matrix
- impregnated
- sample
- reaction
- protein
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims description 36
- 239000000126 substance Substances 0.000 title claims description 33
- 239000011159 matrix material Substances 0.000 claims abstract description 76
- 238000006243 chemical reaction Methods 0.000 claims abstract description 63
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 35
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 26
- 239000008103 glucose Substances 0.000 claims description 26
- 102000004169 proteins and genes Human genes 0.000 claims description 20
- 108090000623 proteins and genes Proteins 0.000 claims description 20
- 210000002966 serum Anatomy 0.000 claims description 10
- 210000001124 body fluid Anatomy 0.000 claims description 7
- 239000010839 body fluid Substances 0.000 claims description 7
- 239000008363 phosphate buffer Substances 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 6
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- 102000003929 Transaminases Human genes 0.000 claims description 4
- 108090000340 Transaminases Proteins 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 238000009826 distribution Methods 0.000 claims description 4
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims description 4
- 102000009027 Albumins Human genes 0.000 claims description 3
- 108010088751 Albumins Proteins 0.000 claims description 3
- 229950006238 nadide Drugs 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims description 2
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims description 2
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims description 2
- KVRGDVMQISBTKV-UHFFFAOYSA-N acetic acid;oxalic acid Chemical compound CC(O)=O.OC(=O)C(O)=O KVRGDVMQISBTKV-UHFFFAOYSA-N 0.000 claims description 2
- 102000020006 aldose 1-epimerase Human genes 0.000 claims description 2
- 108091022872 aldose 1-epimerase Proteins 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- 238000001125 extrusion Methods 0.000 claims description 2
- 229930195712 glutamate Natural products 0.000 claims description 2
- 125000006306 4-iodophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1I 0.000 claims 1
- SHVOAEFVBWFZKE-UHFFFAOYSA-N 5-phenyl-2H-tetrazol-1-ium chloride Chemical compound [Cl-].C1=CC=CC=C1C1=[NH+]NN=N1 SHVOAEFVBWFZKE-UHFFFAOYSA-N 0.000 claims 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 230000001112 coagulating effect Effects 0.000 claims 1
- 229910000365 copper sulfate Inorganic materials 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 claims 1
- 229940074439 potassium sodium tartrate Drugs 0.000 claims 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 32
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 29
- 239000006260 foam Substances 0.000 description 21
- 239000010410 layer Substances 0.000 description 15
- 238000011156 evaluation Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 230000008033 biological extinction Effects 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 239000002250 absorbent Substances 0.000 description 6
- 230000002745 absorbent Effects 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- -1 blank Substances 0.000 description 5
- 230000002452 interceptive effect Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 239000012085 test solution Substances 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000002255 enzymatic effect Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229920002635 polyurethane Polymers 0.000 description 4
- 239000004814 polyurethane Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 229920005830 Polyurethane Foam Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000011496 polyurethane foam Substances 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- JJMQRJKPLUACSO-UHFFFAOYSA-N 3-(4-iodophenyl)-2-(4-nitrophenyl)-5-phenyl-1,3-dihydrotetrazol-3-ium;chloride Chemical compound [Cl-].C1=CC([N+](=O)[O-])=CC=C1N1N(C=2C=CC(I)=CC=2)[NH2+]C(C=2C=CC=CC=2)=N1 JJMQRJKPLUACSO-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 108010044467 Isoenzymes Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241001558496 Talpa caeca Species 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000007812 electrochemical assay Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- HELHAJAZNSDZJO-UHFFFAOYSA-L sodium tartrate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)C(O)C([O-])=O HELHAJAZNSDZJO-UHFFFAOYSA-L 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813137014 DE3137014A1 (de) | 1981-09-17 | 1981-09-17 | "testsystem und verfahren zur bestimmung von inhaltsstoffen von fluessigkeiten". |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS248032B2 true CS248032B2 (en) | 1987-01-15 |
Family
ID=6141969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS826525A CS248032B2 (en) | 1981-09-17 | 1982-09-09 | Determination method of substances in liquids and aid to perform this method |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0075184B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS5862561A (enrdf_load_stackoverflow) |
| CS (1) | CS248032B2 (enrdf_load_stackoverflow) |
| DD (1) | DD204164A5 (enrdf_load_stackoverflow) |
| DE (2) | DE3137014A1 (enrdf_load_stackoverflow) |
| IL (1) | IL66808A0 (enrdf_load_stackoverflow) |
| ZA (1) | ZA826768B (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3505631A1 (de) * | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren und vorrichtung zur herstellung von reagenzloesungen |
| US4898813A (en) * | 1986-04-04 | 1990-02-06 | Albarella James P | Catalytic test composition intended to produce a range of colors |
| FR2610112A1 (fr) * | 1987-01-26 | 1988-07-29 | Ibal | Dispositif pour l'analyse d'une substance par un reactif |
| ATE170981T1 (de) * | 1991-03-28 | 1998-09-15 | Nippon Shoji Kk | Einfache analysenvorrichtung |
| EP0941306A1 (en) * | 1996-11-27 | 1999-09-15 | Durand (Assignees) Limited | Methods and apparatus for enhancement of mass transfer of a fluid in a porous matrix system containing biomass |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3275416A (en) * | 1962-12-10 | 1966-09-27 | Pharmica Ab | Process and device for separating barbituric acid derivatives from biological samples, and for analyzing same |
| IT1006557B (it) * | 1971-09-08 | 1976-10-20 | Bagshawe Kenneth Dawson | Cella di reazione particolarmente utile in prove di radioimmunita |
| US3917453A (en) * | 1974-08-16 | 1975-11-04 | Polaroid Corp | Method and device for determining the concentration of a substance in a fluid |
| US3933594A (en) * | 1974-08-16 | 1976-01-20 | Polaroid Corporation | Method and device for determining the concentration of a substance in a fluid |
| DE2557060C3 (de) * | 1975-12-18 | 1979-07-19 | Riedel-De Haen Ag, 3016 Seelze | Verfahren und Vorrichtung zur Bestimmung von in Lösung befindlichen Ionen |
-
1981
- 1981-09-17 DE DE19813137014 patent/DE3137014A1/de not_active Withdrawn
-
1982
- 1982-09-08 EP EP82108237A patent/EP0075184B1/de not_active Expired
- 1982-09-08 DE DE8282108237T patent/DE3262156D1/de not_active Expired
- 1982-09-09 CS CS826525A patent/CS248032B2/cs unknown
- 1982-09-15 DD DD82243273A patent/DD204164A5/de unknown
- 1982-09-15 ZA ZA826768A patent/ZA826768B/xx unknown
- 1982-09-16 IL IL66808A patent/IL66808A0/xx unknown
- 1982-09-17 JP JP57161079A patent/JPS5862561A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5862561A (ja) | 1983-04-14 |
| IL66808A0 (en) | 1982-12-31 |
| DD204164A5 (de) | 1983-11-16 |
| DE3262156D1 (en) | 1985-03-14 |
| EP0075184A1 (de) | 1983-03-30 |
| DE3137014A1 (de) | 1983-03-24 |
| EP0075184B1 (de) | 1985-01-30 |
| ZA826768B (en) | 1983-07-27 |
| JPH0321070B2 (enrdf_load_stackoverflow) | 1991-03-20 |
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