CS235986B2 - Method of 1,1-dioxopenicilanoyloxy-methyl-6-beta-amino- penicilanate production - Google Patents

Method of 1,1-dioxopenicilanoyloxy-methyl-6-beta-amino- penicilanate production Download PDF

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Publication number
CS235986B2
CS235986B2 CS838030A CS803083A CS235986B2 CS 235986 B2 CS235986 B2 CS 235986B2 CS 838030 A CS838030 A CS 838030A CS 803083 A CS803083 A CS 803083A CS 235986 B2 CS235986 B2 CS 235986B2
Authority
CS
Czechoslovakia
Prior art keywords
mixture
formula
solution
temperature
vacuo
Prior art date
Application number
CS838030A
Other languages
Czech (cs)
English (en)
Inventor
Paul D Weeks
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS235986B2 publication Critical patent/CS235986B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cultivation Of Plants (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS838030A 1982-11-01 1983-10-26 Method of 1,1-dioxopenicilanoyloxy-methyl-6-beta-amino- penicilanate production CS235986B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/438,228 US4530792A (en) 1982-11-01 1982-11-01 Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate

Publications (1)

Publication Number Publication Date
CS235986B2 true CS235986B2 (en) 1985-05-15

Family

ID=23739781

Family Applications (1)

Application Number Title Priority Date Filing Date
CS838030A CS235986B2 (en) 1982-11-01 1983-10-26 Method of 1,1-dioxopenicilanoyloxy-methyl-6-beta-amino- penicilanate production

Country Status (25)

Country Link
US (1) US4530792A (fr)
EP (1) EP0108545B1 (fr)
JP (1) JPS5998090A (fr)
KR (1) KR860001494B1 (fr)
AT (1) ATE24322T1 (fr)
AU (1) AU541962B2 (fr)
CA (1) CA1204736A (fr)
CS (1) CS235986B2 (fr)
DD (1) DD213926A5 (fr)
DE (1) DE3368417D1 (fr)
DK (1) DK163515C (fr)
EG (1) EG15987A (fr)
ES (1) ES8602014A1 (fr)
FI (1) FI76576C (fr)
GR (1) GR78943B (fr)
GT (1) GT198303898A (fr)
HU (1) HU189769B (fr)
IE (1) IE56179B1 (fr)
IL (1) IL70095A (fr)
NZ (1) NZ206108A (fr)
PH (1) PH19573A (fr)
PL (1) PL142735B1 (fr)
PT (1) PT77580B (fr)
YU (1) YU43989B (fr)
ZA (1) ZA838091B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法
GB2231049A (en) * 1989-04-14 1990-11-07 Yoshitomi Pharmaceutical Method for producing diester compounds
DE69103003T2 (de) * 1990-04-13 1994-11-03 Pfizer Inc., Groton, Conn. Verfahren für sultamicillinzwischenprodukt.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896110A (en) * 1971-10-04 1975-07-22 American Home Prod Process for preparation of 6-aminopenicillanic acid
GB1382736A (en) * 1971-11-16 1975-02-05 Yamanouchi Pharma Co Ltd Process of producing semi-synthetic penicillin
FR2275460A1 (fr) * 1974-06-20 1976-01-16 Schmoller & Bompard Procede pour la preparation de l'acide 6-aminopenicillanique
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4364957A (en) * 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4376076A (en) * 1981-03-23 1983-03-08 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4375434A (en) * 1982-06-21 1983-03-01 Pfizer Inc. Process for 6'-amino-penicillanoyloxymethyl penicillanate 1,1-dioxide

Also Published As

Publication number Publication date
US4530792A (en) 1985-07-23
CA1204736A (fr) 1986-05-20
HU189769B (en) 1986-07-28
FI833961A0 (fi) 1983-10-28
YU43989B (en) 1990-02-28
YU216283A (en) 1986-02-28
FI833961A (fi) 1984-05-02
IE832539L (en) 1984-05-01
DK497483D0 (da) 1983-10-31
PT77580A (en) 1983-11-01
NZ206108A (en) 1986-06-11
GT198303898A (es) 1985-04-20
EP0108545A1 (fr) 1984-05-16
EG15987A (en) 1989-03-30
DD213926A5 (de) 1984-09-26
FI76576C (fi) 1988-11-10
AU2082183A (en) 1984-05-10
KR840007009A (ko) 1984-12-04
ZA838091B (en) 1985-06-26
PL142735B1 (en) 1987-11-30
PT77580B (en) 1986-05-27
IE56179B1 (en) 1991-05-08
DK497483A (da) 1984-05-02
JPS5998090A (ja) 1984-06-06
IL70095A (en) 1988-03-31
IL70095A0 (en) 1984-01-31
AU541962B2 (en) 1985-01-31
EP0108545B1 (fr) 1986-12-17
DK163515B (da) 1992-03-09
GR78943B (fr) 1984-10-02
DE3368417D1 (en) 1987-01-29
ATE24322T1 (de) 1987-01-15
JPH0329796B2 (fr) 1991-04-25
KR860001494B1 (ko) 1986-09-27
FI76576B (fi) 1988-07-29
ES526942A0 (es) 1985-11-01
DK163515C (da) 1992-08-24
PL244352A1 (en) 1985-02-27
ES8602014A1 (es) 1985-11-01
PH19573A (en) 1986-05-21

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