CS228526B2 - Method of preparing 8-arylalkyl-3-phenyl-3-nortropanols - Google Patents
Method of preparing 8-arylalkyl-3-phenyl-3-nortropanols Download PDFInfo
- Publication number
- CS228526B2 CS228526B2 CS818894A CS889481A CS228526B2 CS 228526 B2 CS228526 B2 CS 228526B2 CS 818894 A CS818894 A CS 818894A CS 889481 A CS889481 A CS 889481A CS 228526 B2 CS228526 B2 CS 228526B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- formula
- acid
- hcl
- ch3so3h
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803045688 DE3045688A1 (de) | 1980-12-04 | 1980-12-04 | Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
CS228526B2 true CS228526B2 (en) | 1984-05-14 |
Family
ID=6118272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS818894A CS228526B2 (en) | 1980-12-04 | 1981-12-01 | Method of preparing 8-arylalkyl-3-phenyl-3-nortropanols |
Country Status (22)
Country | Link |
---|---|
US (1) | US4393069A (es) |
EP (1) | EP0053744A1 (es) |
JP (1) | JPS57120588A (es) |
KR (1) | KR830007571A (es) |
AR (1) | AR227450A1 (es) |
AU (1) | AU7822281A (es) |
CA (1) | CA1143734A (es) |
CS (1) | CS228526B2 (es) |
DE (1) | DE3045688A1 (es) |
DK (1) | DK536381A (es) |
ES (1) | ES8301980A1 (es) |
FI (1) | FI813862L (es) |
GB (1) | GB2088869B (es) |
GR (1) | GR77312B (es) |
HU (1) | HU185157B (es) |
IL (1) | IL64444A (es) |
NO (1) | NO814136L (es) |
NZ (1) | NZ199162A (es) |
PH (1) | PH17180A (es) |
PT (1) | PT74080B (es) |
SU (1) | SU1042617A3 (es) |
ZA (1) | ZA818371B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
SK232890A3 (en) * | 1989-05-17 | 1998-11-04 | Pfizer | 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof |
EP0398578B1 (en) * | 1989-05-17 | 1997-03-12 | Pfizer Inc. | 2-piperidino-1-alkanol derivatives as antiischemic agents |
US5272160A (en) * | 1989-05-17 | 1993-12-21 | Pfizer Inc | 2-piperidino-1-alkanol derivatives as antiischemic agents |
ES2146578T3 (es) * | 1990-05-10 | 2000-08-16 | Pfizer | Indolona neuroprotectora y derivados relacionados. |
US5340936A (en) * | 1991-02-04 | 1994-08-23 | Hoechst-Roussel Pharmaceuticals Inc. | 8-azabicyclo[3.2.1]octane methanone and corresponding oximes |
WO1992018502A1 (en) * | 1991-04-18 | 1992-10-29 | Pfizer Inc. | Prodrug esters of phenolic 2-piperidino-1-alkanols |
US5710168A (en) * | 1991-10-23 | 1998-01-20 | Pfizer Inc. | 2-piperidino-1-alkanol derivatives as neuroprotective agents |
US5527912A (en) * | 1991-10-23 | 1996-06-18 | Pfizer Inc. | Intermediates for 2-piperidino-1-alkanol derivatives |
US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
US5770180A (en) * | 1992-08-24 | 1998-06-23 | Organix, Inc. | Bridge-substituted tropanes for methods of imaging and therapy |
US5506359A (en) * | 1992-08-24 | 1996-04-09 | President And Fellows Of Harvard College | Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
ATE183184T1 (de) * | 1994-01-31 | 1999-08-15 | Pfizer | Neuroprotektive chroman verbindungen |
GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
IL126882A0 (en) * | 1996-05-13 | 1999-09-22 | Zeneca Ltd | Bicyclic amines as insecticides |
GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
WO1998025924A1 (en) | 1996-11-26 | 1998-06-18 | Zeneca Limited | 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides |
CA2438318A1 (en) * | 2001-02-16 | 2002-08-29 | Aventis Pharmaceuticals Inc. | Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2921938A (en) * | 1960-01-19 | Certain | ||
FR837273A (fr) | 1938-04-29 | 1939-02-07 | Blindage de guerre | |
GB644115A (en) * | 1948-02-25 | 1950-10-04 | Wellcome Found | Improvements in and relating to the preparation of new derivatives of tropine |
BE639446A (es) * | 1962-11-03 | |||
US3452029A (en) * | 1966-11-21 | 1969-06-24 | American Home Prod | 3-alpha-phenylbenzyloxy - 8 - substituted nortropanes and their substitutents |
US3657252A (en) * | 1968-10-25 | 1972-04-18 | Smith Kline French Lab | 3-phenyl - 8-benzofuranylalkyl derivatives of nortropine and notropidine |
-
1980
- 1980-12-04 DE DE19803045688 patent/DE3045688A1/de not_active Withdrawn
-
1981
- 1981-11-19 EP EP81109767A patent/EP0053744A1/de not_active Ceased
- 1981-11-24 SU SU813355198A patent/SU1042617A3/ru active
- 1981-11-25 US US06/324,680 patent/US4393069A/en not_active Expired - Fee Related
- 1981-12-01 CS CS818894A patent/CS228526B2/cs unknown
- 1981-12-02 FI FI813862A patent/FI813862L/fi not_active Application Discontinuation
- 1981-12-02 AR AR287672A patent/AR227450A1/es active
- 1981-12-02 GR GR66672A patent/GR77312B/el unknown
- 1981-12-03 CA CA000391426A patent/CA1143734A/en not_active Expired
- 1981-12-03 DK DK536381A patent/DK536381A/da not_active Application Discontinuation
- 1981-12-03 HU HU813639A patent/HU185157B/hu unknown
- 1981-12-03 NO NO814136A patent/NO814136L/no unknown
- 1981-12-03 GB GB8136493A patent/GB2088869B/en not_active Expired
- 1981-12-03 JP JP56195082A patent/JPS57120588A/ja active Pending
- 1981-12-03 IL IL64444A patent/IL64444A/xx unknown
- 1981-12-03 ZA ZA818371A patent/ZA818371B/xx unknown
- 1981-12-03 AU AU78222/81A patent/AU7822281A/en not_active Abandoned
- 1981-12-03 PT PT74080A patent/PT74080B/pt unknown
- 1981-12-03 NZ NZ199162A patent/NZ199162A/en unknown
- 1981-12-03 ES ES507667A patent/ES8301980A1/es not_active Expired
- 1981-12-04 KR KR1019810004732A patent/KR830007571A/ko unknown
- 1981-12-04 PH PH26572A patent/PH17180A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI813862L (fi) | 1982-06-05 |
HU185157B (en) | 1984-12-28 |
GR77312B (es) | 1984-09-11 |
IL64444A (en) | 1985-02-28 |
KR830007571A (ko) | 1983-10-21 |
DE3045688A1 (de) | 1982-07-08 |
PT74080A (de) | 1982-01-01 |
ZA818371B (en) | 1983-08-31 |
ES507667A0 (es) | 1983-01-01 |
AR227450A1 (es) | 1982-10-29 |
NO814136L (no) | 1982-06-07 |
GB2088869B (en) | 1984-07-18 |
NZ199162A (en) | 1984-11-09 |
AU7822281A (en) | 1982-06-10 |
SU1042617A3 (ru) | 1983-09-15 |
GB2088869A (en) | 1982-06-16 |
PH17180A (en) | 1984-06-13 |
DK536381A (da) | 1982-06-05 |
CA1143734A (en) | 1983-03-29 |
US4393069A (en) | 1983-07-12 |
PT74080B (de) | 1983-12-19 |
ES8301980A1 (es) | 1983-01-01 |
EP0053744A1 (de) | 1982-06-16 |
IL64444A0 (en) | 1982-03-31 |
JPS57120588A (en) | 1982-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CS228526B2 (en) | Method of preparing 8-arylalkyl-3-phenyl-3-nortropanols | |
JPH02243688A (ja) | 新規キヌクリジン類、該化合物を含有する医薬組成物、及びその製造方法 | |
JP2661699B2 (ja) | ピペリジンオピオイド拮抗剤 | |
EP0372466A2 (en) | 2-Amino-4 or 5-methoxycyclohexyl amides useful as analgesics | |
JPH11503143A (ja) | 5ht▲下1d▼ アンタゴニストとしてのビフェニルアミド誘導体 | |
CZ113898A3 (cs) | Kondenzované tropanové deriváty, způsob jejich výroby, farmaceutické prostředky, které je obsahují a jejich použití k léčení | |
EP0029707B1 (en) | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | |
JPS6216952B2 (es) | ||
EP0325406B1 (en) | Diamine compounds | |
GB1563989A (en) | Sulfonamides | |
JP2003516967A (ja) | 1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用 | |
US9463187B2 (en) | Methylphenidate derivatives and uses of them | |
EP0981515B1 (en) | Piperidine derivatives as neurotransmitter re-uptake inhibitors | |
IE53959B1 (en) | 2,2-disubstituted-ethylamines | |
JPH0373551B2 (es) | ||
US4424225A (en) | Thienobenzodiazepinones, pharmaceutical compositions thereof and method of use thereof | |
KR100196263B1 (ko) | 아로일 우레아 유도체 | |
HU201759B (en) | Process for producing new condensed diazepinones and pharmaceutical compositions comprising same | |
US4410527A (en) | Substituted thienobenzodiazepinones and salts thereof | |
AU597187B2 (en) | 2-{ (4-piperidyl)methyl}benzofuro{2,3-c}pyridine derivatives, their preparation and their application in therapy | |
AU597936B2 (en) | Tetracyclic quinazolin derivatives | |
JPH0373550B2 (es) | ||
US3960872A (en) | 1 Alkyl-4-(10:oxo or hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compounds | |
EP0375536B1 (en) | Derivatives of 1,7'-(imidazo-(1,2-a)pyridine) 5'-(6'H) ones and process for their preparation | |
HU201758B (en) | Process for producing new condensed diazepinones and pharmaceutical compositions comprising same |