GB644115A - Improvements in and relating to the preparation of new derivatives of tropine - Google Patents
Improvements in and relating to the preparation of new derivatives of tropineInfo
- Publication number
- GB644115A GB644115A GB563248A GB563248A GB644115A GB 644115 A GB644115 A GB 644115A GB 563248 A GB563248 A GB 563248A GB 563248 A GB563248 A GB 563248A GB 644115 A GB644115 A GB 644115A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tropine
- relating
- preparation
- aryl
- new derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
3-Aryl-tropan-3-ols are obtained by treating tropanone with an aryl lithium compound and hydrolysing the product. The aryl radical may contain alkyl and alkoxy substituents. The bases may be converted into salts, or, by the action of alkyl or aralkyl halides, methosulphates or other reactive acid salts, into quaternary salts. Examples show the production of 3-phenyltropan-3-o1 and its hydrochloride and methiodide.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB563248A GB644115A (en) | 1948-02-25 | 1948-02-25 | Improvements in and relating to the preparation of new derivatives of tropine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB563248A GB644115A (en) | 1948-02-25 | 1948-02-25 | Improvements in and relating to the preparation of new derivatives of tropine |
Publications (1)
Publication Number | Publication Date |
---|---|
GB644115A true GB644115A (en) | 1950-10-04 |
Family
ID=9799727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB563248A Expired GB644115A (en) | 1948-02-25 | 1948-02-25 | Improvements in and relating to the preparation of new derivatives of tropine |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB644115A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2921938A (en) * | 1960-01-19 | Certain | ||
US3073829A (en) * | 1963-01-15 | Certificate of correction | ||
US3120537A (en) * | 1958-04-30 | 1964-02-04 | Sterling Drug Inc | 3-(monocarbocyclic aryl)-3-carboxytropanes and esters thereof |
US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
US4393069A (en) * | 1980-12-04 | 1983-07-12 | C. H. Boehringer Sohn | 8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof |
EP0195498A2 (en) * | 1985-02-26 | 1986-09-24 | Mobil Oil Corporation | Tropane derivatives, their synthesis and their use |
-
1948
- 1948-02-25 GB GB563248A patent/GB644115A/en not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2921938A (en) * | 1960-01-19 | Certain | ||
US3073829A (en) * | 1963-01-15 | Certificate of correction | ||
US3120537A (en) * | 1958-04-30 | 1964-02-04 | Sterling Drug Inc | 3-(monocarbocyclic aryl)-3-carboxytropanes and esters thereof |
US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
US4393069A (en) * | 1980-12-04 | 1983-07-12 | C. H. Boehringer Sohn | 8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof |
EP0195498A2 (en) * | 1985-02-26 | 1986-09-24 | Mobil Oil Corporation | Tropane derivatives, their synthesis and their use |
EP0195498A3 (en) * | 1985-02-26 | 1988-12-14 | Mobil Oil Corporation | Tropane derivatives, their synthesis and their use |
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