CS226441B2 - Method of preparing bicyclic 1-oxa-beta-lactam antibiotics - Google Patents

Method of preparing bicyclic 1-oxa-beta-lactam antibiotics Download PDF

Info

Publication number
CS226441B2
CS226441B2 CS816870A CS687081A CS226441B2 CS 226441 B2 CS226441 B2 CS 226441B2 CS 816870 A CS816870 A CS 816870A CS 687081 A CS687081 A CS 687081A CS 226441 B2 CS226441 B2 CS 226441B2
Authority
CS
Czechoslovakia
Prior art keywords
group
formula
reaction
protecting group
cyanomethyl
Prior art date
Application number
CS816870A
Other languages
Czech (cs)
English (en)
Inventor
Allen S Katner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS226441B2 publication Critical patent/CS226441B2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D505/00Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS816870A 1980-09-17 1981-09-17 Method of preparing bicyclic 1-oxa-beta-lactam antibiotics CS226441B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/187,862 US4301282A (en) 1980-09-17 1980-09-17 1-Oxa-β-lactam antibiotics

Publications (1)

Publication Number Publication Date
CS226441B2 true CS226441B2 (en) 1984-03-19

Family

ID=22690804

Family Applications (1)

Application Number Title Priority Date Filing Date
CS816870A CS226441B2 (en) 1980-09-17 1981-09-17 Method of preparing bicyclic 1-oxa-beta-lactam antibiotics

Country Status (22)

Country Link
US (1) US4301282A (xx)
EP (1) EP0048166A1 (xx)
JP (1) JPS5781488A (xx)
KR (1) KR830007663A (xx)
AU (1) AU7528181A (xx)
BG (1) BG35044A3 (xx)
CA (1) CA1174676A (xx)
CS (1) CS226441B2 (xx)
DD (1) DD200300A5 (xx)
DK (1) DK411881A (xx)
ES (1) ES8303419A1 (xx)
FI (1) FI812779L (xx)
GB (1) GB2084143B (xx)
GR (1) GR75779B (xx)
HU (1) HU184880B (xx)
PH (1) PH16461A (xx)
PL (1) PL132040B1 (xx)
PT (1) PT73683B (xx)
RO (1) RO82035A (xx)
SU (1) SU1028249A3 (xx)
YU (1) YU222781A (xx)
ZA (1) ZA816227B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3365945D1 (en) * 1982-03-20 1986-10-16 Dynamit Nobel Ag Process for preparing 5-chloro-1h-tetrazolo-1-carboxylic-acid esters, and a process for preparing the appropriate dichloroisonitrile-carboxylic-acid esters
JPS60123490A (ja) * 1983-12-07 1985-07-02 Shionogi & Co Ltd マロニルオキサセフェムカルボン酸誘導体
US4855419A (en) * 1987-06-16 1989-08-08 University Of Cincinnati Application of 4-[1-oxoalkyl]-2,5-oxazolidinediones in selective stereospecific formation of biologically active α-lactams
US5006661A (en) * 1987-06-16 1991-04-09 University Of Cincinnati Selective stereospecific biologically active beta-lactams

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
GB1510794A (en) * 1974-08-06 1978-05-17 Univ Kingston 1-oxacephems and intermediates therefor
CA1085392A (en) * 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins

Also Published As

Publication number Publication date
PL233055A1 (xx) 1982-03-29
GR75779B (xx) 1984-08-02
BG35044A3 (en) 1984-01-16
ES505553A0 (es) 1983-02-01
DK411881A (da) 1982-03-18
RO82035A (ro) 1983-06-01
KR830007663A (ko) 1983-11-04
PL132040B1 (en) 1985-01-31
FI812779L (fi) 1982-03-18
RO82035B (ro) 1983-05-30
SU1028249A3 (ru) 1983-07-07
CA1174676A (en) 1984-09-18
JPS5781488A (en) 1982-05-21
AU7528181A (en) 1982-03-25
GB2084143B (en) 1984-11-14
PT73683B (en) 1982-11-26
PH16461A (en) 1983-10-14
YU222781A (en) 1983-10-31
GB2084143A (en) 1982-04-07
DD200300A5 (de) 1983-04-13
EP0048166A1 (en) 1982-03-24
US4301282A (en) 1981-11-17
ES8303419A1 (es) 1983-02-01
HU184880B (en) 1984-10-29
ZA816227B (en) 1983-04-27
PT73683A (en) 1981-10-01

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