CS214887B2 - Method of preparation of new dihydrobenzopyranoxantheno - Google Patents

Method of preparation of new dihydrobenzopyranoxantheno Download PDF

Info

Publication number
CS214887B2
CS214887B2 CS78793A CS79378A CS214887B2 CS 214887 B2 CS214887 B2 CS 214887B2 CS 78793 A CS78793 A CS 78793A CS 79378 A CS79378 A CS 79378A CS 214887 B2 CS214887 B2 CS 214887B2
Authority
CS
Czechoslovakia
Prior art keywords
dimethyl
benzopyrano
compound
formula
mixture
Prior art date
Application number
CS78793A
Other languages
Czech (cs)
English (en)
Inventor
Michael E Flaugh
David A Hall
Richard E Heiney
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/800,674 external-priority patent/US4082627A/en
Priority claimed from US05/800,673 external-priority patent/US4081458A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to CS792143A priority Critical patent/CS214888B2/cs
Publication of CS214887B2 publication Critical patent/CS214887B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CS78793A 1977-05-26 1978-02-07 Method of preparation of new dihydrobenzopyranoxantheno CS214887B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS792143A CS214888B2 (cs) 1977-05-26 1979-03-30 Způsob přípravy nových liexahydrobenzopyraiioxanthenonů

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/800,674 US4082627A (en) 1977-05-26 1977-05-26 Electrolytic reduction of dihydrobenzopyranoxanthenones
US05/800,673 US4081458A (en) 1977-05-26 1977-05-26 Anti-androgen compounds

Publications (1)

Publication Number Publication Date
CS214887B2 true CS214887B2 (en) 1982-06-25

Family

ID=27122240

Family Applications (1)

Application Number Title Priority Date Filing Date
CS78793A CS214887B2 (en) 1977-05-26 1978-02-07 Method of preparation of new dihydrobenzopyranoxantheno

Country Status (25)

Country Link
JP (1) JPS53147099A (el)
AR (1) AR225133A1 (el)
AT (1) AT361920B (el)
AU (1) AU515424B2 (el)
BG (1) BG30020A3 (el)
CS (1) CS214887B2 (el)
DD (1) DD134766A5 (el)
DE (1) DE2804682A1 (el)
DK (1) DK52978A (el)
ES (1) ES466756A1 (el)
FR (1) FR2392026A1 (el)
GB (1) GB1593643A (el)
GR (1) GR69964B (el)
HU (1) HU180230B (el)
IE (1) IE46392B1 (el)
IL (1) IL53990A (el)
IT (1) IT1092577B (el)
NL (1) NL7801392A (el)
NZ (1) NZ186387A (el)
PL (1) PL110214B1 (el)
PT (1) PT67611B (el)
RO (1) RO74948A (el)
SE (1) SE7801419L (el)
SU (3) SU793395A3 (el)
YU (1) YU26378A (el)

Also Published As

Publication number Publication date
BG30020A3 (en) 1981-03-16
FR2392026B1 (el) 1980-12-26
FR2392026A1 (fr) 1978-12-22
AU3302278A (en) 1979-08-16
ES466756A1 (es) 1979-10-01
GB1593643A (en) 1981-07-22
PT67611B (en) 1979-07-16
AT361920B (de) 1981-04-10
IT7820058A0 (it) 1978-02-07
YU26378A (en) 1983-02-28
DD134766A5 (de) 1979-03-21
SE7801419L (sv) 1978-11-27
NL7801392A (nl) 1978-11-28
ATA85178A (de) 1980-09-15
PL204508A1 (pl) 1979-01-02
GR69964B (el) 1982-07-22
IT1092577B (it) 1985-07-12
AR225133A1 (es) 1982-02-26
DE2804682A1 (de) 1978-11-30
SU793395A3 (ru) 1980-12-30
SU927117A3 (ru) 1982-05-07
HU180230B (en) 1983-02-28
RO74948A (ro) 1980-10-30
SU818485A3 (ru) 1981-03-30
IE780232L (en) 1978-11-26
PT67611A (en) 1978-03-01
IE46392B1 (en) 1983-06-01
IL53990A (en) 1981-09-13
JPS53147099A (en) 1978-12-21
NZ186387A (en) 1979-06-08
DK52978A (da) 1978-11-27
PL110214B1 (en) 1980-07-31
AU515424B2 (en) 1981-04-02

Similar Documents

Publication Publication Date Title
Micheli et al. Total syntheses of optically active 19-nor steroids.(+)-Estr-4-ene-3, 17-dione and (+)-13. beta.-ethylgon-4-ene-3, 17-dione
Hauser et al. Anthra [1, 2-b] pyran antibiotics: total synthesis of O-methylkidamycinone
Harvey et al. Synthesis of the dihydrodiol and diol epoxide metabolites of chrysene and 5-methylchrysene
Hajos et al. Stereocontrolled total synthesis of 19-norsteroids
Hansen Jr et al. A stereospecific total synthesis of the anthracyclinones (.+-.)-daunomycinone and (.+-.)-isodaunomycinone
Grieco et al. Synthesis of mono-and bifunctional. alpha.-methylene lactone systems as potential tumor inhibitors
Sangaiah et al. Synthesis of new cyclopenta-fused polycyclic aromatic hydrocarbon isomers of cata-annelated benzenoid systems
TADA et al. Sesquiterpenes of lauraceae plants. IV. Germacranolides from Laurus nobilis L.
Van et al. Synthesis of 6H-naphtho [2, 3-c] chromene-7, 12-diones via palladium-catalyzed intramolecular cyclization of 2-bromo-3-aryloxymethyl-1, 4-naphthoquinones
Hauser et al. Syntheses of. alpha.-and. beta.-sorigenin methyl ethers
Blouin et al. Regiospecific and highly stereoselective formation of benzisochroman-6, 9-quinones. Synthesis of (.+-.)-ventilagone and (.+-.)-ventiloquinone H
Pataki et al. An efficient synthesis of the highly tumorigenic anti-diol epoxide derivative of benzo [c] phenanthrene
Chexal et al. The biosynthesis of fungal metabolites. Part V. Structure of variecoxanthones A, B, and C, metabolites of Aspergillus variecolor; conversion of variecoxanthone A into (±)-de-C-prenylepishamixanthone
CS214887B2 (en) Method of preparation of new dihydrobenzopyranoxantheno
US4264510A (en) Intermediates in the production of anthracycline antibiotics
Kumar Synthesis of trans-10, 11-dihydroxy-10, 11-dihydrodibenz (a, h) acridine and its diastereomeric epoxides. Possible carcinogenic metabolites of dibenz (a, h) acridine
Abad et al. Enantioselective synthesis of herbertane sesquiterpenes: synthesis of (−)-α-formylherbertenol
KR810001936B1 (ko) 항안드로겐 화합물의 제조방법
Bleasdale et al. 2-Benzopyran-3-ones as synthetic building blocks; regioselective Diels–Alder additions with simple olefins leading to aromatic steroids
Caine et al. Total synthesis of dl-3-oxodiplophyllin and dl-yomogin
Sicherer‐Roetman et al. Investigations into the total synthesis of momilactones. Stereoselective preparation of (±)‐4, 4‐dinor‐9βH‐pimara‐7, 19‐diene
Harvey et al. Synthesis of the trans-3, 4-dihydrodiol metabolites of the steroid-related carcinogen 15, 16-dihydrocyclopenta [a] phenanthren-17-one and its 11-methyl derivative
KR810001975B1 (ko) 항 안드로겐 화합물의 제조방법
CA1113105A (en) Anti-androgen compounds
Young et al. Synthesis of the active dihydrodiol and diol epoxide metabolites of the steroid-related carcinogen 15, 16-dihydrocyclopenta [a] phenanthrene and its 11-methyl derivative