CS207666B2 - Method of making the 2-bromergosin and the additive salts thereof with the acid - Google Patents

Method of making the 2-bromergosin and the additive salts thereof with the acid Download PDF

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Publication number
CS207666B2
CS207666B2 CS785746A CS574678A CS207666B2 CS 207666 B2 CS207666 B2 CS 207666B2 CS 785746 A CS785746 A CS 785746A CS 574678 A CS574678 A CS 574678A CS 207666 B2 CS207666 B2 CS 207666B2
Authority
CS
Czechoslovakia
Prior art keywords
bromoergosine
blood pressure
methanesulfonate
rats
effect
Prior art date
Application number
CS785746A
Other languages
Czech (cs)
English (en)
Inventor
Rudolf Rucman
Nebojsa Djordjevic
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Publication of CS207666B2 publication Critical patent/CS207666B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CS785746A 1977-09-09 1978-09-05 Method of making the 2-bromergosin and the additive salts thereof with the acid CS207666B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU02161/77A YU216177A (en) 1977-09-09 1977-09-09 Process for preparing 2-bromo ergosine

Publications (1)

Publication Number Publication Date
CS207666B2 true CS207666B2 (en) 1981-08-31

Family

ID=25557072

Family Applications (1)

Application Number Title Priority Date Filing Date
CS785746A CS207666B2 (en) 1977-09-09 1978-09-05 Method of making the 2-bromergosin and the additive salts thereof with the acid

Country Status (8)

Country Link
US (1) US4219555A (es)
EP (1) EP0001115A3 (es)
CS (1) CS207666B2 (es)
ES (1) ES472847A1 (es)
FI (1) FI782666A (es)
PT (1) PT68447A (es)
SU (1) SU891674A1 (es)
YU (1) YU216177A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU39786B (en) * 1976-12-23 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-alfa-ergocriptine
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
US4609731A (en) * 1979-10-10 1986-09-02 Sandoz Ltd. Process for brominating ergot alkaloids
CH649300A5 (de) * 1981-08-07 1985-05-15 Sandoz Ag Ergopeptinderivate, ihre herstellung und verwendung.
DE3340025C2 (de) * 1983-11-03 1986-01-09 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen
GB8426922D0 (en) * 1984-10-24 1984-11-28 Sandoz Ltd Galenic formulation
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
US5585347A (en) * 1988-05-10 1996-12-17 Ergo Science Incorporated Methods for the determination and adjustment of prolactin daily rhythms
US5668155A (en) * 1988-05-10 1997-09-16 The General Hospital Corporation Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders
US5830895A (en) * 1988-05-10 1998-11-03 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Methods for the determination and adjustment of prolactin daily rhythms
US5744477A (en) * 1988-05-10 1998-04-28 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for treatment of obesity using prolactin modulators and diet
US5006526A (en) * 1988-10-17 1991-04-09 Louisiana State University Method of treating a vertebrate animal to reduce plasma triglycerides and cholesterol levels and to alleviate and prevent atherosclerosis
IL112106A0 (en) * 1993-12-22 1995-03-15 Ergo Science Inc Accelerated release composition containing bromocriptine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2497214A (en) * 1946-03-18 1950-02-14 William F Dreyer Stud extractor tool
FR7775M (es) * 1967-06-28 1970-03-23
CH507249A (de) * 1968-05-31 1971-05-15 Sandoz Ag Verfahren zur Herstellung von 2-Brom-a-ergokryptin
GB1298277A (en) * 1969-04-18 1972-11-29 Sandoz Ltd Preparation of ergot peptide alkaloids
US3920664A (en) * 1972-07-21 1975-11-18 Lilly Co Eli D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US3883655A (en) * 1973-10-11 1975-05-13 Sandoz Ltd Ergocornine or 2-bromo-{60 -ergocyptine in the treatment of parkinsonism
US4138565A (en) * 1975-05-31 1979-02-06 Sandoz Ltd. Stable solutions and processes for their preparation
US4124712A (en) * 1976-09-06 1978-11-07 Sandoz Ltd. Ergot peptide alkaloid derivatives
YU39786B (en) 1976-12-23 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-alfa-ergocriptine

Also Published As

Publication number Publication date
EP0001115A3 (de) 1979-04-04
US4219555A (en) 1980-08-26
ES472847A1 (es) 1979-10-16
SU891674A1 (ru) 1981-12-23
YU216177A (en) 1984-02-29
FI782666A (fi) 1979-03-10
PT68447A (en) 1978-09-01
EP0001115A2 (de) 1979-03-21

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