CS200341B1 - Pharmaceutical medicament against poisn by organophosphoric pesticides - Google Patents
Pharmaceutical medicament against poisn by organophosphoric pesticides Download PDFInfo
- Publication number
- CS200341B1 CS200341B1 CS775266A CS526677A CS200341B1 CS 200341 B1 CS200341 B1 CS 200341B1 CS 775266 A CS775266 A CS 775266A CS 526677 A CS526677 A CS 526677A CS 200341 B1 CS200341 B1 CS 200341B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- poisoning
- pesticides
- pharmaceutical composition
- pharmaceutical
- organophosphoric
- Prior art date
Links
- 239000000575 pesticide Substances 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 title description 3
- 231100000572 poisoning Toxicity 0.000 claims description 16
- 230000000607 poisoning effect Effects 0.000 claims description 16
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- PHTMLLGDZBZXMW-AERCQKQUSA-N etybenzatropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2CC)C(C=1C=CC=CC=1)C1=CC=CC=C1 PHTMLLGDZBZXMW-AERCQKQUSA-N 0.000 claims description 2
- 229960003561 etybenzatropine Drugs 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- XYEGKWRSSKWLAC-UHFFFAOYSA-N Cl.C1(=CC=CC=C1)C(C(C)C)(O)N Chemical compound Cl.C1(=CC=CC=C1)C(C(C)C)(O)N XYEGKWRSSKWLAC-UHFFFAOYSA-N 0.000 abstract 1
- HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 abstract 1
- 239000000729 antidote Substances 0.000 abstract 1
- 229960002028 atropine sulfate Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 description 20
- 208000005374 Poisoning Diseases 0.000 description 15
- 229930003347 Atropine Natural products 0.000 description 10
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 10
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 10
- 229960000396 atropine Drugs 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 5
- 231100000570 acute poisoning Toxicity 0.000 description 5
- GEPDYQSQVLXLEU-AATRIKPKSA-N methyl (e)-3-dimethoxyphosphoryloxybut-2-enoate Chemical compound COC(=O)\C=C(/C)OP(=O)(OC)OC GEPDYQSQVLXLEU-AATRIKPKSA-N 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- 238000010255 intramuscular injection Methods 0.000 description 4
- 239000007927 intramuscular injection Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 239000003708 ampul Substances 0.000 description 2
- -1 difluoro bromophenylacetate Chemical compound 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 231100000566 intoxication Toxicity 0.000 description 2
- 230000035987 intoxication Effects 0.000 description 2
- 231100000636 lethal dose Toxicity 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- JBKPUQTUERUYQE-UHFFFAOYSA-O pralidoxime Chemical compound C[N+]1=CC=CC=C1\C=N\O JBKPUQTUERUYQE-UHFFFAOYSA-O 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 231100001229 severe poisoning Toxicity 0.000 description 2
- 231100001274 therapeutic index Toxicity 0.000 description 2
- BZQGAPWJKAYCHR-UHFFFAOYSA-N 3,3-diphenylpropanoic acid Chemical compound C=1C=CC=CC=1C(CC(=O)O)C1=CC=CC=C1 BZQGAPWJKAYCHR-UHFFFAOYSA-N 0.000 description 1
- 206010008428 Chemical poisoning Diseases 0.000 description 1
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960002534 ephedrine hydrochloride Drugs 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- HIGRLDNHDGYWQJ-UHFFFAOYSA-P obidoxime Chemical compound C1=CC(=C[NH+]=O)C=CN1COCN1C=CC(=C[NH+]=O)C=C1 HIGRLDNHDGYWQJ-UHFFFAOYSA-P 0.000 description 1
- 229960004429 obidoxime Drugs 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 239000003987 organophosphate pesticide Substances 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- JHZHWVQTOXIXIV-UHFFFAOYSA-N oxo-[[1-[3-[4-(oxoazaniumylmethylidene)pyridin-1-yl]propyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCCN1C=CC(=C[NH+]=O)C=C1 JHZHWVQTOXIXIV-UHFFFAOYSA-N 0.000 description 1
- ZIFJVJZWVSPZLE-UHFFFAOYSA-N oxo-[[1-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxymethyl]pyridin-4-ylidene]methyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COCN1C=CC(=C[NH+]=O)C=C1 ZIFJVJZWVSPZLE-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229960003370 pralidoxime Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 239000005315 stained glass Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG33997A BG23257A1 (en:Method) | 1976-08-13 | 1976-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS200341B1 true CS200341B1 (en) | 1980-09-15 |
Family
ID=3902517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS775266A CS200341B1 (en) | 1976-08-13 | 1977-08-09 | Pharmaceutical medicament against poisn by organophosphoric pesticides |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5324034A (en:Method) |
| BE (1) | BE857727A (en:Method) |
| BG (1) | BG23257A1 (en:Method) |
| CA (1) | CA1087096A (en:Method) |
| CS (1) | CS200341B1 (en:Method) |
| DE (1) | DE2736060A1 (en:Method) |
| FR (1) | FR2361113B1 (en:Method) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2426464A1 (fr) * | 1978-05-23 | 1979-12-21 | Dso Pharmachim | Antidote prophylactique contre les pesticides organophosphoriques |
| JPS54160744A (en) * | 1978-06-06 | 1979-12-19 | Dso Pharmachim | Preventing and detoxifying agent against organic phosphorous insecticide |
| JPS5855093B2 (ja) * | 1979-02-16 | 1983-12-08 | 新日本製鐵株式会社 | スラグの安定化及び冷却のための処理方法 |
-
1976
- 1976-08-13 BG BG33997A patent/BG23257A1/xx unknown
-
1977
- 1977-08-05 FR FR7724229A patent/FR2361113B1/fr not_active Expired
- 1977-08-09 CS CS775266A patent/CS200341B1/cs unknown
- 1977-08-10 DE DE19772736060 patent/DE2736060A1/de not_active Withdrawn
- 1977-08-11 CA CA284,644A patent/CA1087096A/en not_active Expired
- 1977-08-12 BE BE2056156A patent/BE857727A/xx unknown
- 1977-08-12 JP JP9743477A patent/JPS5324034A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BE857727A (fr) | 1977-12-01 |
| FR2361113B1 (fr) | 1980-04-25 |
| JPS5324034A (en) | 1978-03-06 |
| BG23257A1 (en:Method) | 1977-08-10 |
| DE2736060A1 (de) | 1978-02-16 |
| FR2361113A1 (en) | 1978-03-10 |
| CA1087096A (en) | 1980-10-07 |
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