CS200166B2 - Method of producing n-substituted prostaglandincarboxamides - Google Patents
Method of producing n-substituted prostaglandincarboxamides Download PDFInfo
- Publication number
- CS200166B2 CS200166B2 CS734136A CS413673A CS200166B2 CS 200166 B2 CS200166 B2 CS 200166B2 CS 734136 A CS734136 A CS 734136A CS 413673 A CS413673 A CS 413673A CS 200166 B2 CS200166 B2 CS 200166B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- trans
- cis
- substituted
- carboxamide
- multiplet
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 7
- -1 C 3-8 cycloalkanoyl Chemical group 0.000 claims abstract description 31
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 8
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- 229910052736 halogen Chemical group 0.000 claims abstract description 4
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- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 13
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- 230000008569 process Effects 0.000 claims description 6
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- 125000001424 substituent group Chemical group 0.000 claims description 4
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- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS774936A CS200167B2 (cs) | 1972-06-07 | 1977-07-25 | Způsob výroby ll,15-bis(tetrahydropyranyl)etheru prostaglandinkarboxamidu |
| CS774937A CS200168B2 (cs) | 1972-06-07 | 1977-07-25 | Způsob výroby substituovaného karboxamidtrifenylfosfoniumbromidu |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26051872A | 1972-06-07 | 1972-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS200166B2 true CS200166B2 (en) | 1980-08-29 |
Family
ID=22989486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS734136A CS200166B2 (en) | 1972-06-07 | 1973-06-07 | Method of producing n-substituted prostaglandincarboxamides |
Country Status (24)
| Country | Link |
|---|---|
| JP (2) | JPS5715591B2 (xx) |
| AR (1) | AR207434A1 (xx) |
| AT (1) | AT340069B (xx) |
| BE (1) | BE800580A (xx) |
| CA (1) | CA985280A (xx) |
| CH (3) | CH593929A5 (xx) |
| CS (1) | CS200166B2 (xx) |
| DD (2) | DD115687A5 (xx) |
| DE (1) | DE2329092A1 (xx) |
| ES (3) | ES415611A1 (xx) |
| FI (1) | FI58327C (xx) |
| FR (2) | FR2187344B1 (xx) |
| GB (2) | GB1439512A (xx) |
| HU (3) | HU170487B (xx) |
| IE (1) | IE38058B1 (xx) |
| IL (2) | IL42385A (xx) |
| IN (1) | IN138966B (xx) |
| LU (1) | LU67754A1 (xx) |
| NL (2) | NL160814C (xx) |
| NO (2) | NO146538C (xx) |
| PH (2) | PH14204A (xx) |
| SE (3) | SE415883B (xx) |
| YU (1) | YU36498B (xx) |
| ZA (1) | ZA733763B (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX3291E (es) * | 1975-04-23 | 1980-08-22 | Upjohn Co | Procedimiento para preparar analogos de prostaglandinas |
| US6395787B1 (en) | 2000-02-08 | 2002-05-28 | Allergan Sales, Inc. | Ocular hypotensive lipids |
| US6476064B1 (en) * | 2001-06-13 | 2002-11-05 | Allergan, Inc. | Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3187043A (en) * | 1962-05-18 | 1965-06-01 | Monsanto Co | Monohalophosphonium halides |
-
1973
- 1973-01-01 AR AR248467A patent/AR207434A1/es active
- 1973-05-28 SE SE7307522A patent/SE415883B/xx unknown
- 1973-05-29 GB GB4209675A patent/GB1439512A/en not_active Expired
- 1973-05-29 IL IL42385A patent/IL42385A/xx unknown
- 1973-05-29 CA CA172,672A patent/CA985280A/en not_active Expired
- 1973-05-29 GB GB2561373A patent/GB1439511A/en not_active Expired
- 1973-05-30 FI FI1762/73A patent/FI58327C/fi active
- 1973-05-31 IN IN1278/CAL/73A patent/IN138966B/en unknown
- 1973-06-04 ZA ZA733763A patent/ZA733763B/xx unknown
- 1973-06-04 PH PH14689A patent/PH14204A/en unknown
- 1973-06-05 IE IE896/73A patent/IE38058B1/xx unknown
- 1973-06-06 NL NL7307867.A patent/NL160814C/xx not_active IP Right Cessation
- 1973-06-06 NO NO2379/73A patent/NO146538C/no unknown
- 1973-06-06 HU HUPI384A patent/HU170487B/hu unknown
- 1973-06-06 HU HUPI476A patent/HU170491B/hu unknown
- 1973-06-06 HU HUPI477A patent/HU170200B/hu unknown
- 1973-06-06 ES ES415611A patent/ES415611A1/es not_active Expired
- 1973-06-07 CH CH831273A patent/CH593929A5/xx not_active IP Right Cessation
- 1973-06-07 FR FR7320753A patent/FR2187344B1/fr not_active Expired
- 1973-06-07 YU YU01526/73A patent/YU36498B/xx unknown
- 1973-06-07 DE DE2329092A patent/DE2329092A1/de not_active Ceased
- 1973-06-07 CH CH1535876A patent/CH591511A5/xx not_active IP Right Cessation
- 1973-06-07 CH CH1535976A patent/CH605887A5/xx not_active IP Right Cessation
- 1973-06-07 DD DD180810*A patent/DD115687A5/xx unknown
- 1973-06-07 CS CS734136A patent/CS200166B2/cs unknown
- 1973-06-07 JP JP6435173A patent/JPS5715591B2/ja not_active Expired
- 1973-06-07 AT AT504873A patent/AT340069B/de not_active IP Right Cessation
- 1973-06-07 DD DD171393A patent/DD109211A5/xx unknown
- 1973-06-07 LU LU67754A patent/LU67754A1/xx unknown
- 1973-06-07 BE BE1005125A patent/BE800580A/xx not_active IP Right Cessation
-
1974
- 1974-03-11 NO NO740850A patent/NO142784C/no unknown
- 1974-09-26 ES ES430416A patent/ES430416A1/es not_active Expired
- 1974-09-26 ES ES430417A patent/ES430417A1/es not_active Expired
-
1975
- 1975-06-06 FR FR7517790A patent/FR2273814A1/fr active Granted
- 1975-06-25 PH PH17314A patent/PH13092A/en unknown
-
1976
- 1976-07-19 SE SE7608224A patent/SE418744B/xx unknown
- 1976-07-19 SE SE7608225A patent/SE7608225L/xx not_active Application Discontinuation
-
1977
- 1977-02-23 IL IL51525A patent/IL51525A0/xx unknown
-
1978
- 1978-12-14 NL NL7812163A patent/NL7812163A/xx not_active Application Discontinuation
-
1981
- 1981-06-10 JP JP8940881A patent/JPS5731692A/ja active Pending
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