CS195652B2 - Method of producing new 4-diphenylmethylen-1-hydroxy-benzylpiperidines - Google Patents

Method of producing new 4-diphenylmethylen-1-hydroxy-benzylpiperidines Download PDF

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Publication number
CS195652B2
CS195652B2 CS78170A CS17078A CS195652B2 CS 195652 B2 CS195652 B2 CS 195652B2 CS 78170 A CS78170 A CS 78170A CS 17078 A CS17078 A CS 17078A CS 195652 B2 CS195652 B2 CS 195652B2
Authority
CS
Czechoslovakia
Prior art keywords
found
calculated
piperidine
hcl
melting point
Prior art date
Application number
CS78170A
Other languages
Czech (cs)
English (en)
Inventor
Dusan Zivkovic
Original Assignee
Ucb S A Saint Gilles Lez Bruxe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S A Saint Gilles Lez Bruxe filed Critical Ucb S A Saint Gilles Lez Bruxe
Publication of CS195652B2 publication Critical patent/CS195652B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS78170A 1977-01-11 1978-01-09 Method of producing new 4-diphenylmethylen-1-hydroxy-benzylpiperidines CS195652B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB931/77A GB1542823A (en) 1977-01-11 1977-01-11 Piperidine derivatives

Publications (1)

Publication Number Publication Date
CS195652B2 true CS195652B2 (en) 1980-02-29

Family

ID=9713045

Family Applications (1)

Application Number Title Priority Date Filing Date
CS78170A CS195652B2 (en) 1977-01-11 1978-01-09 Method of producing new 4-diphenylmethylen-1-hydroxy-benzylpiperidines

Country Status (22)

Country Link
JP (1) JPS5387367A (fr)
BE (1) BE862769A (fr)
BG (1) BG28574A3 (fr)
CA (1) CA1101426A (fr)
CS (1) CS195652B2 (fr)
DD (1) DD134089A5 (fr)
DE (1) DE2800919A1 (fr)
DK (1) DK5778A (fr)
ES (1) ES465861A1 (fr)
FI (1) FI780028A (fr)
FR (1) FR2376846A1 (fr)
GB (1) GB1542823A (fr)
IL (1) IL53766A0 (fr)
IT (1) IT1103117B (fr)
LU (1) LU78839A1 (fr)
NL (1) NL7800146A (fr)
NO (1) NO780040L (fr)
PL (1) PL203912A1 (fr)
PT (1) PT67511B (fr)
SE (1) SE7800184L (fr)
SU (2) SU772482A3 (fr)
ZA (1) ZA78158B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650874A (en) * 1984-11-26 1987-03-17 G. D. Searle & Co. N-(aralkoxybenzyl)-4(benzhydryl) piperidines
US4628095A (en) * 1985-06-05 1986-12-09 G. D. Searle & Co. Substituted N-benzyl-4-(benzhydryl) piperidines
EP0235463A3 (fr) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl et arylalkylène piperidines substitués sur l'azote utilisés comme agents antihistaminiques cardiovasculaires et antisécrétion
GB9000305D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Anticholinergic agents
DE19681115D2 (de) * 1995-12-20 1999-11-25 Eckhart Pein Neue 1-Phenylalkyl/Alkylen-4-(.Alpha.-Hydroxydiphenylmethyl)-Piperidin Derivative und ihre Verwendung als Serotonin Antagonisten
ES2237078T3 (es) * 1998-01-16 2005-07-16 Eisai Co., Ltd. Procedimiento para producir derivados de donepezilo.
AU2003296373A1 (en) * 2002-12-18 2004-07-29 Bayer Cropscience Ag N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
WO2004103972A1 (fr) * 2003-05-20 2004-12-02 Ajinomoto Co.,Inc. Nouveau derive de piperidine

Also Published As

Publication number Publication date
BG28574A3 (en) 1980-05-15
BE862769A (fr) 1978-07-10
ES465861A1 (es) 1978-09-16
IT7847573A0 (it) 1978-01-10
FR2376846A1 (fr) 1978-08-04
PT67511B (fr) 1979-06-11
SU990761A1 (ru) 1983-01-23
DD134089A5 (de) 1979-02-07
GB1542823A (en) 1979-03-28
LU78839A1 (fr) 1978-09-18
IL53766A0 (en) 1978-04-30
JPS5387367A (en) 1978-08-01
ZA78158B (en) 1978-10-25
NO780040L (no) 1978-07-12
JPS6125031B2 (fr) 1986-06-13
NL7800146A (nl) 1978-07-13
PT67511A (fr) 1978-02-01
SE7800184L (sv) 1978-07-12
DE2800919A1 (de) 1978-07-13
CA1101426A (fr) 1981-05-19
SU772482A3 (ru) 1980-10-15
FI780028A (fi) 1978-07-12
PL203912A1 (pl) 1979-06-04
FR2376846B1 (fr) 1983-02-04
IT1103117B (it) 1985-10-14
DK5778A (da) 1978-07-12

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