CR20230507A - Anticuerpos anti-il-2r agonistas y métodos de uso - Google Patents

Anticuerpos anti-il-2r agonistas y métodos de uso

Info

Publication number
CR20230507A
CR20230507A CR20230507A CR20230507A CR20230507A CR 20230507 A CR20230507 A CR 20230507A CR 20230507 A CR20230507 A CR 20230507A CR 20230507 A CR20230507 A CR 20230507A CR 20230507 A CR20230507 A CR 20230507A
Authority
CR
Costa Rica
Prior art keywords
antibodies
methods
agonistic anti
compositions
il2rb
Prior art date
Application number
CR20230507A
Other languages
English (en)
Inventor
Chaudhry Harbani Kaur Malik
Kaitlyn Loughlin
Nathan Trinklein
Kyle Lorentsen
Katherine Harris
Original Assignee
Teneobio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teneobio Inc filed Critical Teneobio Inc
Publication of CR20230507A publication Critical patent/CR20230507A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan anticuerpos anti-IL2R (por ejemplo, anti-IL2RB, anti-IL2RG, anti-IL2RB/G), junto con métodos de elaboración de estos anticuerpos, composiciones, incluidas composiciones farmacéuticas, que comprenden estos anticuerpos, y el uso de los anticuerpos y composiciones en el tratamiento de enfermedades y trastornos que se median por la vía de señalización de IL2/IL2R.
CR20230507A 2021-04-02 2022-04-01 Anticuerpos anti-il-2r agonistas y métodos de uso CR20230507A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163170383P 2021-04-02 2021-04-02
US202163239883P 2021-09-01 2021-09-01
PCT/US2022/023058 WO2022212848A1 (en) 2021-04-02 2022-04-01 Agonistic anti-il-2r antibodies and methods of use

Publications (1)

Publication Number Publication Date
CR20230507A true CR20230507A (es) 2023-12-12

Family

ID=81385128

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230507A CR20230507A (es) 2021-04-02 2022-04-01 Anticuerpos anti-il-2r agonistas y métodos de uso

Country Status (16)

Country Link
US (2) US11884735B2 (es)
EP (1) EP4314067A1 (es)
JP (1) JP2024512982A (es)
KR (1) KR20230165263A (es)
AU (1) AU2022252398A1 (es)
BR (1) BR112023020219A2 (es)
CA (1) CA3214587A1 (es)
CL (1) CL2023002895A1 (es)
CO (1) CO2023014054A2 (es)
CR (1) CR20230507A (es)
IL (1) IL305944A (es)
MX (1) MX2023011624A (es)
PE (1) PE20240913A1 (es)
TW (1) TW202304994A (es)
UY (1) UY39715A (es)
WO (1) WO2022212848A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202005880XA (en) 2017-12-22 2020-07-29 Teneobio Inc Heavy chain antibodies binding to cd22
CR20210622A (es) 2019-06-14 2022-06-27 Teneobio Inc Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DK0590058T3 (da) 1991-06-14 2004-03-29 Genentech Inc Humaniseret heregulin-antistof
JP3255699B2 (ja) 1992-04-23 2002-02-12 味の素株式会社 ヒトＩＬ−２レセプターγ鎖分子
EP0804578B1 (en) 1995-01-09 2008-07-16 Boehringer Ingelheim International GmbH Il-2r-associated polypeptide and dna molecules coding therefor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
AU728657B2 (en) 1996-03-18 2001-01-18 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
EP0918858A1 (en) 1996-05-10 1999-06-02 Biogen, Inc. Common gamma chain blocking agents
US6103879A (en) 1996-06-21 2000-08-15 Axys Pharmaceuticals, Inc. Bivalent molecules that form an activating complex with an erythropoietin receptor
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
HUE025086T2 (en) 2002-10-10 2016-02-29 Merck Patent Gmbh Pharmaceutical preparations for ERB-B1 receptor
CA2499300A1 (en) 2002-10-31 2004-05-21 Genentech, Inc. Methods and compositions for increasing antibody production
CA2513113A1 (en) 2003-01-23 2004-08-05 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
RU2398882C2 (ru) 2004-07-22 2010-09-10 Эрасмус Юниверсити Медикал Сентр Роттердам СПОСОБ ПОЛУЧЕНИЯ АНТИГЕН-СВЯЗЫВАЮЩЕГО ДОМЕНА Vh ИСПОЛЬЗОВАНИЕ
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
SI2235064T1 (sl) 2008-01-07 2016-04-29 Amgen Inc. Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
US20100122358A1 (en) 2008-06-06 2010-05-13 Crescendo Biologics Limited H-Chain-only antibodies
AU2010224160A1 (en) 2009-03-10 2011-09-22 Biogen Idec Ma Inc. Anti-BCMA antibodies
GB0905023D0 (en) 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
US9028830B2 (en) 2010-04-08 2015-05-12 JN Biosciences, LLC Antibodies to CD122
EP2691417B1 (en) 2011-03-29 2018-08-01 Roche Glycart AG Antibody fc variants
WO2014087248A2 (en) 2012-12-03 2014-06-12 Novimmune S.A. Anti-cd47 antibodies and methods of use thereof
US9546203B2 (en) 2013-03-14 2017-01-17 Amgen Inc. Aglycosylated Fc-containing polypeptides with cysteine substitutions
JP2016520586A (ja) 2013-05-08 2016-07-14 ザイムワークス，インコーポレイテッド 二重特異性ｈｅｒ２およびｈｅｒ３抗原結合性構築物
ES2710618T3 (es) 2015-08-06 2019-04-26 Agency Science Tech & Res Anticuerpos frente a IL2R-Beta/cadena gamma común
EP3471773A4 (en) 2016-06-21 2020-07-08 Teneobio, Inc. ANTIBODIES BINDING CD3
CA3034706A1 (en) 2016-08-24 2018-03-01 Teneobio, Inc. Transgenic non-human animals producing modified heavy chain-only antibodies
CR20220408A (es) 2016-09-14 2022-10-20 Teneobio Inc ANTICUERPOS DE UNIÓN A CD3(Divisional del Expediente 2019-198)
SG11202004172UA (en) 2017-11-10 2020-06-29 Agency Science Tech & Res Il2rbeta/common gamma chain antibodies
TW202039557A (zh) * 2018-11-09 2020-11-01 新加坡商優其洛伊生物私人有限公司 介白素2受體β(IL2Rβ)/共同γ鏈抗體
WO2020094834A1 (en) * 2018-11-09 2020-05-14 Euchloe Bio Pte. Ltd. Il2rbeta/common gamma chain antibodies
US11629195B2 (en) 2019-02-01 2023-04-18 Regeneron Pharmaceuticals, Inc. Anti-IL2 receptor gamma antigen-binding proteins

Also Published As

Publication number Publication date
MX2023011624A (es) 2023-10-11
WO2022212848A1 (en) 2022-10-06
US20230242653A1 (en) 2023-08-03
CO2023014054A2 (es) 2023-11-10
UY39715A (es) 2022-10-31
CL2023002895A1 (es) 2024-02-02
AU2022252398A1 (en) 2023-09-21
AU2022252398A9 (en) 2024-01-11
US20240018250A1 (en) 2024-01-18
TW202304994A (zh) 2023-02-01
IL305944A (en) 2023-11-01
PE20240913A1 (es) 2024-04-30
JP2024512982A (ja) 2024-03-21
CA3214587A1 (en) 2022-10-06
KR20230165263A (ko) 2023-12-05
EP4314067A1 (en) 2024-02-07
BR112023020219A2 (pt) 2024-02-06
US11884735B2 (en) 2024-01-30

Similar Documents

Publication Publication Date Title
MX2023011624A (es) Anticuerpos anti-il-2r agonistas y metodos de uso.
PH12020500241A1 (en) Cytokine conjugates for the treatment of autoimmune diseases
PH12019502058A1 (en) Farnesoid x receptor agonists and uses thereof
CR20210500A (es) Anticuerpos de cadena pesada que se unen al psma
PH12021550605A1 (en) Farnesoid x receptor agonists and uses thereof
MX2022001776A (es) Terapias de combinacion de inmuno oncologia con conjugados de il-2.
JOP20210323A1 (ar) ارتباط أجسام مضادة ثقيلة السلسلة ومتعددة النوعية بـ cd22 وcd3
MX2018010032A (es) Formulaciones de antagonista de il-6 y sus usos.
MX2021004517A (es) Inhibidores de cinasa de janus 1 triciclicos y composiciones y metodos de los mismos.
MX2021002916A (es) Pirfenidona enriquecida con deuterio y métodos para su uso.
MX2021007235A (es) Tubulisinas y conjugados de proteina-tubulisina.
MX2023003677A (es) Inhibidores de hidroxiesteroide 17beta- deshidrogenasa 13 (hsd17b13) y usos de estos.
CR20230180A (es) Inhibidores de interleucina-17
MX2023010711A (es) Fenalquilaminas y métodos de preparación y uso de las mismas.
MX2023009874A (es) Anticuerpos anti-psma y estructuras car-t.
MX2023009882A (es) Anticuerpos anti-muc1-c y estructuras car-t.
CR20230525A (es) Anticuerpos anti-cd20 y estructuras car-t
MX2023005693A (es) Anticuerpos de cadena pesada que se unen al receptor de folato alfa.
EA202191115A1 (ru) Новые пиридазины
MX2021011596A (es) Compuestos y composiciones como moduladores de se?alizacion tlr.
MX2023003675A (es) Inhibidores de hidroxiesteroide 17beta-deshidrogenasa 13 (hsd17b13) y usos de estos.
MX2021008941A (es) Moduladores gpr35.
WO2018129451A3 (en) Anti-fgfr antibodies and methods of use
MX2022015769A (es) Tubulisinas y conjugados de proteina-tubulisina.
MX2021008507A (es) Moleculas que se unen al receptor leucocitario similar a inmunoglobulina subfamilia b miembro 3 (lilrb3) y usos para las mismas.