CL2023002895A1 - Anticuerpos anti-il-2r agonistas y métodos de uso - Google Patents
Anticuerpos anti-il-2r agonistas y métodos de usoInfo
- Publication number
- CL2023002895A1 CL2023002895A1 CL2023002895A CL2023002895A CL2023002895A1 CL 2023002895 A1 CL2023002895 A1 CL 2023002895A1 CL 2023002895 A CL2023002895 A CL 2023002895A CL 2023002895 A CL2023002895 A CL 2023002895A CL 2023002895 A1 CL2023002895 A1 CL 2023002895A1
- Authority
- CL
- Chile
- Prior art keywords
- antibodies
- methods
- agonist antibodies
- compositions
- il2rb
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 abstract 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Se divulgan anticuerpos anti-IL2R (por ejemplo, anti-IL2RB, anti-IL2RG, anti-IL2RB/G), junto con métodos de elaboración de estos anticuerpos, composiciones, incluidas composiciones farmacéuticas, que comprenden estos anticuerpos, y el uso de los anticuerpos y composiciones en el tratamiento de enfermedades y trastornos que se median por la vía de señalización de IL2/IL2R.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163170383P | 2021-04-02 | 2021-04-02 | |
US202163239883P | 2021-09-01 | 2021-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2023002895A1 true CL2023002895A1 (es) | 2024-02-02 |
Family
ID=81385128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2023002895A CL2023002895A1 (es) | 2021-04-02 | 2023-09-28 | Anticuerpos anti-il-2r agonistas y métodos de uso |
Country Status (14)
Country | Link |
---|---|
US (2) | US11884735B2 (es) |
EP (1) | EP4314067A1 (es) |
JP (1) | JP2024512982A (es) |
KR (1) | KR20230165263A (es) |
AU (1) | AU2022252398A1 (es) |
BR (1) | BR112023020219A2 (es) |
CA (1) | CA3214587A1 (es) |
CL (1) | CL2023002895A1 (es) |
CO (1) | CO2023014054A2 (es) |
CR (1) | CR20230507A (es) |
IL (1) | IL305944A (es) |
TW (1) | TW202304994A (es) |
UY (1) | UY39715A (es) |
WO (1) | WO2022212848A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11202005880XA (en) | 2017-12-22 | 2020-07-29 | Teneobio Inc | Heavy chain antibodies binding to cd22 |
AR119746A1 (es) | 2019-06-14 | 2022-01-05 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
JP3255699B2 (ja) | 1992-04-23 | 2002-02-12 | 味の素株式会社 | ヒトIL−2レセプターγ鎖分子 |
US6297028B1 (en) | 1995-01-09 | 2001-10-02 | Boehringer Ingelheim International Gmbh | IL-2R-associated polypeptide and DNA molecules coding therefor |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
WO1997043416A1 (en) | 1996-05-10 | 1997-11-20 | Biogen, Inc. | Common gamma chain blocking agents |
US6103879A (en) | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
PL374586A1 (en) | 2002-10-10 | 2005-10-31 | Merck Patent Gmbh | Bispecific anti-erb-b antibodies and their use in tumor therapy |
MXPA05004677A (es) | 2002-10-31 | 2005-11-17 | Genentech Inc | Metodos y composiciones para aumentar la produccion de anticuerpos. |
EP1585768A2 (en) | 2003-01-23 | 2005-10-19 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
JP2008512987A (ja) | 2004-07-22 | 2008-05-01 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | 結合分子 |
US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
EP2235064B1 (en) | 2008-01-07 | 2015-11-25 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
US20100122358A1 (en) | 2008-06-06 | 2010-05-13 | Crescendo Biologics Limited | H-Chain-only antibodies |
LT2406284T (lt) | 2009-03-10 | 2016-10-10 | Biogen Ma Inc. | Antikūnai prieš b ląstelių subrendimo antigenus |
GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
WO2011127324A2 (en) | 2010-04-08 | 2011-10-13 | JN Biosciences, LLC | Antibodies to cd122 |
KR101614195B1 (ko) | 2011-03-29 | 2016-04-20 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
US11059910B2 (en) | 2012-12-03 | 2021-07-13 | Novimmune Sa | Anti-CD47 antibodies and methods of use thereof |
US9546203B2 (en) | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
CA2910945A1 (en) | 2013-05-08 | 2014-11-13 | Zymeworks Inc. | Bispecific her2 and her3 antigen binding constructs |
US10472421B2 (en) | 2015-08-06 | 2019-11-12 | Agency For Science, Technology And Research | Method for expansion of a population of cells with IL2R beta/common gamma chain antibodies |
KR20190053835A (ko) | 2016-06-21 | 2019-05-20 | 테네오바이오, 인코포레이티드 | Cd3 결합 항체 |
CA3034706A1 (en) | 2016-08-24 | 2018-03-01 | Teneobio, Inc. | Transgenic non-human animals producing modified heavy chain-only antibodies |
UA126384C2 (uk) | 2016-09-14 | 2022-09-28 | Тенеобіо, Інк. | Антитіло, яке зв'язує cd3 |
WO2019092181A1 (en) | 2017-11-10 | 2019-05-16 | Agency For Science, Technology And Research | Il2rbeta/common gamma chain antibodies |
WO2020094834A1 (en) * | 2018-11-09 | 2020-05-14 | Euchloe Bio Pte. Ltd. | Il2rbeta/common gamma chain antibodies |
WO2020094836A1 (en) * | 2018-11-09 | 2020-05-14 | Euchloe Bio Pte. Ltd. | Il2rbeta/common gamma chain antibodies |
EP3917962A1 (en) | 2019-02-01 | 2021-12-08 | Regeneron Pharmaceuticals, Inc. | Anti-il2 receptor gamma antigen-binding proteins |
-
2022
- 2022-03-31 TW TW111112596A patent/TW202304994A/zh unknown
- 2022-04-01 IL IL305944A patent/IL305944A/en unknown
- 2022-04-01 AU AU2022252398A patent/AU2022252398A1/en active Pending
- 2022-04-01 JP JP2023559727A patent/JP2024512982A/ja active Pending
- 2022-04-01 KR KR1020237035936A patent/KR20230165263A/ko unknown
- 2022-04-01 CA CA3214587A patent/CA3214587A1/en active Pending
- 2022-04-01 WO PCT/US2022/023058 patent/WO2022212848A1/en active Application Filing
- 2022-04-01 UY UY0001039715A patent/UY39715A/es unknown
- 2022-04-01 BR BR112023020219A patent/BR112023020219A2/pt unknown
- 2022-04-01 CR CR20230507A patent/CR20230507A/es unknown
- 2022-04-01 EP EP22718473.6A patent/EP4314067A1/en active Pending
-
2023
- 2023-02-03 US US18/164,442 patent/US11884735B2/en active Active
- 2023-08-29 US US18/457,553 patent/US20240018250A1/en active Pending
- 2023-09-28 CL CL2023002895A patent/CL2023002895A1/es unknown
- 2023-10-23 CO CONC2023/0014054A patent/CO2023014054A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW202304994A (zh) | 2023-02-01 |
KR20230165263A (ko) | 2023-12-05 |
US20230242653A1 (en) | 2023-08-03 |
CO2023014054A2 (es) | 2023-11-10 |
JP2024512982A (ja) | 2024-03-21 |
CA3214587A1 (en) | 2022-10-06 |
US20240018250A1 (en) | 2024-01-18 |
AU2022252398A9 (en) | 2024-01-11 |
AU2022252398A1 (en) | 2023-09-21 |
UY39715A (es) | 2022-10-31 |
BR112023020219A2 (pt) | 2024-02-06 |
CR20230507A (es) | 2023-12-12 |
EP4314067A1 (en) | 2024-02-07 |
IL305944A (en) | 2023-11-01 |
US11884735B2 (en) | 2024-01-30 |
WO2022212848A1 (en) | 2022-10-06 |
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