CR20230303A - Composiciones y métodos para reducir el mhc de clase ii en una célula - Google Patents

Composiciones y métodos para reducir el mhc de clase ii en una célula

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Publication number
CR20230303A
CR20230303A CR20230303A CR20230303A CR20230303A CR 20230303 A CR20230303 A CR 20230303A CR 20230303 A CR20230303 A CR 20230303A CR 20230303 A CR20230303 A CR 20230303A CR 20230303 A CR20230303 A CR 20230303A
Authority
CR
Costa Rica
Prior art keywords
cell
compositions
methods
mhc class
reducing
Prior art date
Application number
CR20230303A
Other languages
English (en)
Spanish (es)
Inventor
Yong Zhang
William Frederick Harrington
Surbhi Goel
Srijani Sridhar
Original Assignee
Intellia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellia Therapeutics Inc filed Critical Intellia Therapeutics Inc
Publication of CR20230303A publication Critical patent/CR20230303A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C07K2319/00—Fusion polypeptide
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CR20230303A 2020-12-11 2021-12-10 Composiciones y métodos para reducir el mhc de clase ii en una célula CR20230303A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063124064P 2020-12-11 2020-12-11
US202063130106P 2020-12-23 2020-12-23
PCT/US2021/062946 WO2022125982A1 (en) 2020-12-11 2021-12-10 Compositions and methods for reducing mhc class ii in a cell

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