CR20220018A - Derivados de imidazol [4,5-c] piridina como agonistas de receptores tipo toll - Google Patents

Derivados de imidazol [4,5-c] piridina como agonistas de receptores tipo toll

Info

Publication number
CR20220018A
CR20220018A CR20220018A CR20220018A CR20220018A CR 20220018 A CR20220018 A CR 20220018A CR 20220018 A CR20220018 A CR 20220018A CR 20220018 A CR20220018 A CR 20220018A CR 20220018 A CR20220018 A CR 20220018A
Authority
CR
Costa Rica
Prior art keywords
imidazo
agonsits
toll
receptor
pyridine derivatives
Prior art date
Application number
CR20220018A
Other languages
English (en)
Inventor
Andrew Fensome
Omar Khaled Ahmad
Ethan Lawrence Fisher
Lei Zhang
Erik Alphie Lachapelle
Jun Xiao
Rayomand J Unwalla
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CR20220018A publication Critical patent/CR20220018A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere a compuestos imidazo-piridinilo, o una sal de estos aceptable desde el punto de vista farmaceutico, a composiciones farmaceuticas que comprenden dichos compuestos y sales, y a metodos y usos de dichos compuestos, sales y composiciones para el tratamiento de crecimiento celular anormal, que incluye cancer, en un sujeto que lo necesita.
CR20220018A 2019-07-17 2020-07-14 Derivados de imidazol [4,5-c] piridina como agonistas de receptores tipo toll CR20220018A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875465P 2019-07-17 2019-07-17
US202062961288P 2020-01-15 2020-01-15
PCT/IB2020/056605 WO2021009676A1 (en) 2019-07-17 2020-07-14 Imidazo[4,5-c]pyridine derivatives as toll-like receptor agonsits

Publications (1)

Publication Number Publication Date
CR20220018A true CR20220018A (es) 2022-02-08

Family

ID=71728839

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220018A CR20220018A (es) 2019-07-17 2020-07-14 Derivados de imidazol [4,5-c] piridina como agonistas de receptores tipo toll

Country Status (20)

Country Link
US (2) US11339159B2 (es)
EP (1) EP3999507A1 (es)
JP (1) JP7137733B2 (es)
KR (1) KR20220034862A (es)
CN (1) CN114364677A (es)
AU (1) AU2020315210B2 (es)
BR (1) BR112022000341A2 (es)
CA (1) CA3147266C (es)
CL (1) CL2022000032A1 (es)
CO (1) CO2022000259A2 (es)
CR (1) CR20220018A (es)
CU (1) CU20220003A7 (es)
EC (1) ECSP22003665A (es)
IL (1) IL289877A (es)
MX (1) MX2022000656A (es)
PE (1) PE20220342A1 (es)
TW (1) TWI755788B (es)
UY (1) UY38786A (es)
WO (1) WO2021009676A1 (es)
ZA (1) ZA202201330B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
JP2022525594A (ja) 2019-03-15 2022-05-18 ボルト バイオセラピューティクス、インコーポレーテッド Ｈｅｒ２を標的とする免疫結合体
US11339159B2 (en) * 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists
WO2022153157A1 (en) 2021-01-13 2022-07-21 Pfizer Inc. A crystalline form of 2-((4-amino-2-(ethoxymethyl)-6,7-dimethyl-1 h-imidazo[4,5-c]pyridin-1-yl)methyl)-2-methylpropane-1,3-diol free base
WO2023079428A1 (en) 2021-11-03 2023-05-11 Pfizer Inc. Combination therapies using tlr7/8 agonist

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WO2016001810A1 (en) 2014-07-01 2016-01-07 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof
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ES2848648T3 (es) 2015-12-14 2021-08-11 Glaxosmithkline Biologicals Sa Imidazoquinolinas pegiladas como agonistas de TLR7 y TLR8
CN109563081A (zh) 2016-04-07 2019-04-02 葛兰素史克知识产权开发有限公司 可用作蛋白调节剂的杂环酰胺类
HRP20220936T1 (hr) 2016-04-07 2022-10-28 Glaxosmithkline Intellectual Property Development Limited Heterociklički amidi korisni kao modulatori proteina
US10533007B2 (en) * 2016-04-19 2020-01-14 Innate Tumor Immunity, Inc. NLRP3 modulators
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KR20200015602A (ko) 2017-05-31 2020-02-12 주식회사 에스티큐브앤컴퍼니 Btn1a1에 면역특이적으로 결합하는 항체 및 분자 및 이의 치료적 용도
TWI790120B (zh) 2017-06-02 2023-01-11 美商輝瑞大藥廠 對flt3具特異性之抗體及其用途
MA49772A (fr) 2017-08-04 2021-04-21 Merck Sharp & Dohme Agonistes benzo[b]thiophène de sting pour le traitement du cancer
US11339159B2 (en) * 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists

Also Published As

Publication number Publication date
AU2020315210B2 (en) 2023-01-12
CA3147266C (en) 2023-09-12
PE20220342A1 (es) 2022-03-14
CN114364677A (zh) 2022-04-15
US11339159B2 (en) 2022-05-24
TWI755788B (zh) 2022-02-21
ZA202201330B (en) 2022-10-26
CL2022000032A1 (es) 2022-09-02
CU20220003A7 (es) 2022-08-09
KR20220034862A (ko) 2022-03-18
US20220274986A1 (en) 2022-09-01
WO2021009676A8 (en) 2022-03-03
JP2022534125A (ja) 2022-07-27
JP7137733B2 (ja) 2022-09-14
US11976064B2 (en) 2024-05-07
WO2021009676A1 (en) 2021-01-21
TW202116770A (zh) 2021-05-01
CO2022000259A2 (es) 2022-01-17
MX2022000656A (es) 2022-02-16
BR112022000341A2 (pt) 2022-04-12
IL289877A (en) 2022-03-01
EP3999507A1 (en) 2022-05-25
AU2020315210A1 (en) 2022-02-03
ECSP22003665A (es) 2022-02-25
CA3147266A1 (en) 2021-01-21
UY38786A (es) 2021-02-26
US20210017172A1 (en) 2021-01-21

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