CR20210559A - Anticuerpos anti-sema3a y sus usos para tratar enfermedades oculares - Google Patents

Anticuerpos anti-sema3a y sus usos para tratar enfermedades oculares

Info

Publication number
CR20210559A
CR20210559A CR20210559A CR20210559A CR20210559A CR 20210559 A CR20210559 A CR 20210559A CR 20210559 A CR20210559 A CR 20210559A CR 20210559 A CR20210559 A CR 20210559A CR 20210559 A CR20210559 A CR 20210559A
Authority
CR
Costa Rica
Prior art keywords
ocular diseases
treating eye
sema3a
antibodies
sema3a antibodies
Prior art date
Application number
CR20210559A
Other languages
English (en)
Inventor
Fei Han
Juergen Prestle
Leo Thomas
Kristin Laura Bovat
Dongmei Liu
Helen Haixia Wu
Nina Zippel
Sathyadevi Venkataramani
Priyanka Gupta
Rachel Rebecca Barrett
Sanjaya Singh
Rajkumar Ganesan
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CR20210559A publication Critical patent/CR20210559A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a anticuerpos y fragmentos de estos que actúan sobre semaforina 3A (Sema3A). Más específicamente, se divulgan anticuerpos anti-Sema3A y métodos de uso para el tratamiento de varias enfermedades o trastornos.
CR20210559A 2019-05-09 2020-05-08 Anticuerpos anti-sema3a y sus usos para tratar enfermedades oculares CR20210559A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19173454 2019-05-09
PCT/EP2020/062802 WO2020225400A1 (en) 2019-05-09 2020-05-08 Anti-sema3a antibodies and their uses for treating eye or ocular diseases

Publications (1)

Publication Number Publication Date
CR20210559A true CR20210559A (es) 2021-12-23

Family

ID=66476463

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210559A CR20210559A (es) 2019-05-09 2020-05-08 Anticuerpos anti-sema3a y sus usos para tratar enfermedades oculares

Country Status (22)

Country Link
US (2) US11267880B2 (es)
EP (1) EP3966239A1 (es)
JP (2) JP7314310B2 (es)
KR (1) KR20220007128A (es)
CN (1) CN113795509A (es)
AR (1) AR122266A1 (es)
AU (1) AU2020267874A1 (es)
BR (1) BR112021019854A2 (es)
CA (1) CA3137377A1 (es)
CL (1) CL2021002795A1 (es)
CO (1) CO2021014768A2 (es)
CR (1) CR20210559A (es)
DO (1) DOP2021000226A (es)
EA (1) EA202193038A1 (es)
EC (1) ECSP21082527A (es)
IL (1) IL287758A (es)
JO (1) JOP20210300A1 (es)
MA (1) MA55872A (es)
MX (1) MX2021013671A (es)
PE (1) PE20220287A1 (es)
SG (1) SG11202110842QA (es)
WO (1) WO2020225400A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113795509A (zh) 2019-05-09 2021-12-14 勃林格殷格翰国际有限公司 抗-sema3a抗体及其用于治疗眼或眼部疾病的用途
US20220127344A1 (en) * 2020-10-23 2022-04-28 Boehringer Ingelheim International Gmbh Anti-sema3a antibodies and their uses for treating a thrombotic disease of the retina
KR20230162800A (ko) * 2021-03-30 2023-11-28 바이엘 악티엔게젤샤프트 항-sema3a 항체 및 그의 용도
CN116790610A (zh) * 2023-05-18 2023-09-22 四川大学 一种治疗骨科疾病的基因及以aav为载体的基因治疗药物

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Also Published As

Publication number Publication date
JP7314310B2 (ja) 2023-07-25
JP2023130473A (ja) 2023-09-20
CO2021014768A2 (es) 2021-11-19
US20220144929A1 (en) 2022-05-12
MX2021013671A (es) 2021-12-10
AU2020267874A1 (en) 2021-10-28
JP2022531698A (ja) 2022-07-08
WO2020225400A1 (en) 2020-11-12
ECSP21082527A (es) 2021-12-30
DOP2021000226A (es) 2021-12-15
EP3966239A1 (en) 2022-03-16
CN113795509A (zh) 2021-12-14
TW202108621A (zh) 2021-03-01
CA3137377A1 (en) 2020-11-12
SG11202110842QA (en) 2021-10-28
JOP20210300A1 (ar) 2023-01-30
AR122266A1 (es) 2022-08-31
KR20220007128A (ko) 2022-01-18
US11267880B2 (en) 2022-03-08
CL2021002795A1 (es) 2022-08-05
PE20220287A1 (es) 2022-02-25
US20200385446A1 (en) 2020-12-10
EA202193038A1 (ru) 2022-03-30
IL287758A (en) 2022-01-01
MA55872A (fr) 2022-03-16
BR112021019854A2 (pt) 2022-02-15

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