CR20190201A - Naphthyridinone derivatives and their use in the treatment of arrhythmia - Google Patents

Naphthyridinone derivatives and their use in the treatment of arrhythmia

Info

Publication number
CR20190201A
CR20190201A CR20190201A CR20190201A CR20190201A CR 20190201 A CR20190201 A CR 20190201A CR 20190201 A CR20190201 A CR 20190201A CR 20190201 A CR20190201 A CR 20190201A CR 20190201 A CR20190201 A CR 20190201A
Authority
CR
Costa Rica
Prior art keywords
una
presente
invención
proporciona
present
Prior art date
Application number
CR20190201A
Other languages
Spanish (es)
Inventor
Guillaume Barbe
Sicong Geng
Ruowei Mo
Gregory Raymond Bebernitz
Kayo Yasoshima
David Thomas Parker
Efthymiou Hatice Belgin Gulgeze
Lv Liao
Fupeng Ma
Yunshan Peng
Stefan Peukert
Ken Yamada
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR20190201A publication Critical patent/CR20190201A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.La presente invención proporciona un compuesto de fórmula (I) o una sal farmacéuticamente aceptable del mismo; (I) donde R1, R3¿R6, X2 y X3 son como se define en la presente descripción, un método para elaborar los compuestos de la invención, y sus usos terapéuticos. La presente invención además proporciona una combinación de agentes farmacológicamente activos y una composición farmacéutica
CR20190201A 2016-10-21 2017-10-19 Naphthyridinone derivatives and their use in the treatment of arrhythmia CR20190201A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662410930P 2016-10-21 2016-10-21
CN2016102928 2016-10-21
US201662413292P 2016-10-26 2016-10-26
PCT/IB2017/056515 WO2018073788A1 (en) 2016-10-21 2017-10-19 Naphthyridinone derivatives and their use in the treatment of arrhythmia

Publications (1)

Publication Number Publication Date
CR20190201A true CR20190201A (en) 2019-06-04

Family

ID=60409317

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20190201A CR20190201A (en) 2016-10-21 2017-10-19 Naphthyridinone derivatives and their use in the treatment of arrhythmia

Country Status (33)

Country Link
US (3) US10266531B2 (en)
EP (2) EP3529251B1 (en)
JP (1) JP7030802B2 (en)
KR (1) KR102540872B1 (en)
CN (1) CN109843887B (en)
AU (2) AU2017344489C1 (en)
BR (1) BR112019007863A2 (en)
CA (1) CA3038624A1 (en)
CL (1) CL2019001023A1 (en)
CO (1) CO2019003894A2 (en)
CR (1) CR20190201A (en)
CU (1) CU24599B1 (en)
DO (1) DOP2019000100A (en)
EC (1) ECSP19026973A (en)
ES (1) ES2934234T3 (en)
FI (1) FI3529251T3 (en)
HR (1) HRP20221516T1 (en)
HU (1) HUE060882T2 (en)
IL (1) IL266128B (en)
JO (1) JOP20190086A1 (en)
LT (1) LT3529251T (en)
MX (1) MX2019004484A (en)
PE (1) PE20190735A1 (en)
PH (1) PH12019500849A1 (en)
PL (1) PL3529251T3 (en)
PT (1) PT3529251T (en)
RS (1) RS63841B1 (en)
SA (1) SA519401614B1 (en)
SG (1) SG11201902529WA (en)
SI (1) SI3529251T1 (en)
TW (1) TWI759343B (en)
UY (1) UY37445A (en)
WO (1) WO2018073788A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190086A1 (en) 2016-10-21 2019-04-18 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia
US11866430B2 (en) 2018-06-27 2024-01-09 Bristol-Myers Squibb Company Naphthyridinone compounds useful as T cell activators
WO2022074567A1 (en) * 2020-10-06 2022-04-14 Novartis Ag Pharmaceutical compositions comprising naphthyridinone derivatives and their use in the treatment of arrhythmia
AR127698A1 (en) * 2021-11-23 2024-02-21 Novartis Ag NAFTYRIDINOONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER

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Also Published As

Publication number Publication date
EP4141006A1 (en) 2023-03-01
CA3038624A1 (en) 2018-04-26
CO2019003894A2 (en) 2019-04-30
BR112019007863A2 (en) 2019-07-02
JP2019531326A (en) 2019-10-31
US20210284635A1 (en) 2021-09-16
SA519401614B1 (en) 2022-06-12
CL2019001023A1 (en) 2019-06-21
AU2017344489A1 (en) 2019-04-11
RU2019115344A (en) 2020-11-24
RS63841B1 (en) 2023-01-31
ECSP19026973A (en) 2019-04-30
TW201819377A (en) 2018-06-01
PT3529251T (en) 2022-12-23
AU2017344489B2 (en) 2020-04-02
RU2019115344A3 (en) 2021-02-20
US10266531B2 (en) 2019-04-23
MX2019004484A (en) 2019-08-05
AU2020204341B2 (en) 2021-07-01
WO2018073788A1 (en) 2018-04-26
CU24599B1 (en) 2022-06-06
FI3529251T3 (en) 2023-01-13
CU20190042A7 (en) 2019-11-04
CN109843887A (en) 2019-06-04
ES2934234T3 (en) 2023-02-20
US20190263803A1 (en) 2019-08-29
TWI759343B (en) 2022-04-01
JOP20190086A1 (en) 2019-04-18
SI3529251T1 (en) 2023-01-31
DOP2019000100A (en) 2019-06-16
CN109843887B (en) 2022-05-10
KR102540872B1 (en) 2023-06-08
IL266128B (en) 2021-06-30
HUE060882T2 (en) 2023-04-28
EP3529251A1 (en) 2019-08-28
PL3529251T3 (en) 2023-01-30
US11530213B2 (en) 2022-12-20
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