JPS57176959A - 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation - Google Patents

1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation

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Publication number
JPS57176959A
JPS57176959A JP6124481A JP6124481A JPS57176959A JP S57176959 A JPS57176959 A JP S57176959A JP 6124481 A JP6124481 A JP 6124481A JP 6124481 A JP6124481 A JP 6124481A JP S57176959 A JPS57176959 A JP S57176959A
Authority
JP
Japan
Prior art keywords
acid
dichlorophenyl
methylthio
indole
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6124481A
Other languages
Japanese (ja)
Inventor
Genichi Dobashi
Katsuyuki Ogura
Ryozo Sakota
Shuichi Fukushima
Kazuo Nagano
Ikuo Kawakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP6124481A priority Critical patent/JPS57176959A/en
Publication of JPS57176959A publication Critical patent/JPS57176959A/en
Pending legal-status Critical Current

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  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:1-(2',6'-Dichlorophenyl)-2,3,-bis(methylthio)indole of formulaI.
USE: Useful as an intermediate for the preparation of diclofenac sodium (general name) having pharmacological activities such as antiphlogistic, analgesic and antipyretic activities, and useful as analgesic and antiphlogistic agent, and for the reMedy of rheumatoid arthritis, osteroarthritis, spondylitis deformans, lumbago, neuralgia, etc.
PROCESS: The compound of formulaIcan be prepared by treating 1-[o-(2',6'- dichloroanilino)-phenyl]-2-methylsulfinyl-2-methylthioethylene of formula II with heat or an acid such as a mineral acid e.g. hydrochloric acid, hydrobromic acid, etc. or a Lewis acid such as tin chloride, copper chloride, etc. The reaction proceeds by using a catalytic amount of the mineral acid; however, the use of the acid in excess promotes the reaction. The heat-treatment of the compound of formula II is carried out at ≥200°C.
COPYRIGHT: (C)1982,JPO&Japio
JP6124481A 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation Pending JPS57176959A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6124481A JPS57176959A (en) 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6124481A JPS57176959A (en) 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation

Publications (1)

Publication Number Publication Date
JPS57176959A true JPS57176959A (en) 1982-10-30

Family

ID=13165621

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6124481A Pending JPS57176959A (en) 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation

Country Status (1)

Country Link
JP (1) JPS57176959A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10266531B2 (en) 2016-10-21 2019-04-23 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10266531B2 (en) 2016-10-21 2019-04-23 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia
US10844055B2 (en) 2016-10-21 2020-11-24 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia
US11530213B2 (en) 2016-10-21 2022-12-20 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia

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