JPS57176959A - 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation - Google Patents
1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparationInfo
- Publication number
- JPS57176959A JPS57176959A JP6124481A JP6124481A JPS57176959A JP S57176959 A JPS57176959 A JP S57176959A JP 6124481 A JP6124481 A JP 6124481A JP 6124481 A JP6124481 A JP 6124481A JP S57176959 A JPS57176959 A JP S57176959A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- dichlorophenyl
- methylthio
- indole
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:1-(2',6'-Dichlorophenyl)-2,3,-bis(methylthio)indole of formulaI.
USE: Useful as an intermediate for the preparation of diclofenac sodium (general name) having pharmacological activities such as antiphlogistic, analgesic and antipyretic activities, and useful as analgesic and antiphlogistic agent, and for the reMedy of rheumatoid arthritis, osteroarthritis, spondylitis deformans, lumbago, neuralgia, etc.
PROCESS: The compound of formulaIcan be prepared by treating 1-[o-(2',6'- dichloroanilino)-phenyl]-2-methylsulfinyl-2-methylthioethylene of formula II with heat or an acid such as a mineral acid e.g. hydrochloric acid, hydrobromic acid, etc. or a Lewis acid such as tin chloride, copper chloride, etc. The reaction proceeds by using a catalytic amount of the mineral acid; however, the use of the acid in excess promotes the reaction. The heat-treatment of the compound of formula II is carried out at ≥200°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6124481A JPS57176959A (en) | 1981-04-24 | 1981-04-24 | 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6124481A JPS57176959A (en) | 1981-04-24 | 1981-04-24 | 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57176959A true JPS57176959A (en) | 1982-10-30 |
Family
ID=13165621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6124481A Pending JPS57176959A (en) | 1981-04-24 | 1981-04-24 | 1-(2',6'-dichlorophenyl)-2,3bis(methylthio) indole and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57176959A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10266531B2 (en) | 2016-10-21 | 2019-04-23 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
-
1981
- 1981-04-24 JP JP6124481A patent/JPS57176959A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10266531B2 (en) | 2016-10-21 | 2019-04-23 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
US10844055B2 (en) | 2016-10-21 | 2020-11-24 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
US11530213B2 (en) | 2016-10-21 | 2022-12-20 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
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