CR20170022A - Anticuerpos biespecíficos anti-il4-il13 - Google Patents
Anticuerpos biespecíficos anti-il4-il13Info
- Publication number
- CR20170022A CR20170022A CR20170022A CR20170022A CR20170022A CR 20170022 A CR20170022 A CR 20170022A CR 20170022 A CR20170022 A CR 20170022A CR 20170022 A CR20170022 A CR 20170022A CR 20170022 A CR20170022 A CR 20170022A
- Authority
- CR
- Costa Rica
- Prior art keywords
- fragments
- double
- antibody
- region
- binding proteins
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/521—Chemokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
En el presente documento se desvelan dosis seguras de proteínas de unión de tipo anticuerpo de doble región Vo fragmentos de las mismas, así como métodos para evaluar la unión de proteínas de tipo anticuerpo de doble región V o fragmentos de las mismas a sus dianas y métodos para tratar la fibrosis pulmonar idiopática (FPI) mediante la administración de dosis seguras de proteínas de unión de tipo anticuerpo de doble región V o fragmentos de las mismas. En algunas realizaciones, las proteínas de unión de tipo anticuerpo de doble región V o fragmentos de las mismas se unen tanto a la IL-4 como a la IL-13.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462018253P | 2014-06-27 | 2014-06-27 | |
EP14306477 | 2014-09-24 | ||
US201562102097P | 2015-01-11 | 2015-01-11 | |
PCT/IB2015/001377 WO2015198146A2 (en) | 2014-06-27 | 2015-06-26 | Anti-il4-il 13 bispecific antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20170022A true CR20170022A (es) | 2017-04-04 |
Family
ID=51663114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20170022A CR20170022A (es) | 2014-06-27 | 2015-06-26 | Anticuerpos biespecíficos anti-il4-il13 |
Country Status (18)
Country | Link |
---|---|
US (2) | US20170145089A1 (es) |
EP (1) | EP3160502A2 (es) |
JP (1) | JP2017530089A (es) |
KR (1) | KR102558891B1 (es) |
CN (1) | CN106573975A (es) |
AU (1) | AU2015278829B2 (es) |
BR (1) | BR112016030568B8 (es) |
CA (1) | CA2952902C (es) |
CL (1) | CL2016003317A1 (es) |
CR (1) | CR20170022A (es) |
EA (1) | EA201692495A8 (es) |
MX (1) | MX2017000171A (es) |
NZ (1) | NZ728020A (es) |
PH (1) | PH12016502569A1 (es) |
SG (2) | SG11201610594WA (es) |
TN (1) | TN2016000569A1 (es) |
TW (2) | TWI745962B (es) |
WO (1) | WO2015198146A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
TWI745962B (zh) | 2014-06-27 | 2021-11-11 | 法商賽諾菲公司 | 測定投予至人類個體之包括雙-v-區類抗體蛋白或其片段的劑量是否在人類個體中與il-4或il-13特異性結合之方法 |
US11827671B2 (en) | 2019-05-24 | 2023-11-28 | Sanofi | Methods for treating systemic sclerosis |
WO2023166418A2 (en) * | 2022-03-03 | 2023-09-07 | Pfizer Inc. | Multispecific antibodies and uses thereof |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
IL89489A0 (en) | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
JPH02503867A (ja) | 1988-04-15 | 1990-11-15 | プロテイン デザイン ラブズ インコーポレーテッド | Il‐2レセプター特異的キメラ抗体 |
EP0338745B1 (en) | 1988-04-16 | 1995-03-01 | Celltech Limited | Method for producing recombinant DNA proteins |
US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
AU4025193A (en) | 1992-04-08 | 1993-11-18 | Cetus Oncology Corporation | Humanized C-erbB-2 specific antibodies |
WO1997014719A1 (en) | 1995-10-16 | 1997-04-24 | Unilever N.V. | A bifunctional or bivalent antibody fragment analogue |
JP2005512522A (ja) | 2001-10-26 | 2005-05-12 | セントカー・インコーポレーテツド | Il−13ムテインタンパク質、抗体、組成物、方法および使用 |
US20040023338A1 (en) | 2001-10-26 | 2004-02-05 | Heavner George A. | IL-4 mutein proteins, antibodies, compositions, methods and uses |
WO2006042333A2 (en) | 2004-10-12 | 2006-04-20 | Xencor, Inc. | Prediction and assessment of immunogenicity |
AU2005307831A1 (en) | 2004-11-17 | 2006-05-26 | Amgen, Inc. | Fully human monoclonal antibodies to IL-13 |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
JP2008087194A (ja) | 2006-09-29 | 2008-04-17 | Brother Ind Ltd | インクジェットプリンタ |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
WO2009069355A1 (ja) * | 2007-11-28 | 2009-06-04 | Riken | Il-17rb陽性nkt細胞を用いたアレルギー性気道炎症及び/又は気道過敏症の治療薬のスクリーニング方法 |
JP5439915B2 (ja) | 2009-04-09 | 2014-03-12 | ユニマテック株式会社 | 硬化性含フッ素ポリエーテル組成物 |
EP2427203B1 (en) * | 2009-05-05 | 2018-10-17 | Novimmune S.A. | Anti-il-17f antibodies and use thereof |
JP5305366B2 (ja) | 2009-10-26 | 2013-10-02 | 国立大学法人大阪大学 | 画像特徴抽出装置、画像特徴抽出方法、画像認識装置、及び画像認識方法 |
CN102640001A (zh) * | 2009-11-05 | 2012-08-15 | 诺瓦提斯公司 | 预测纤维化进展的生物标记物 |
SG10201401746TA (en) | 2010-12-16 | 2014-10-30 | Genentech Inc | Diagnosis And Treatments Relating To TH2 Inhibition |
JP2014510730A (ja) | 2011-03-16 | 2014-05-01 | サノフイ | デュアルv領域抗体様タンパク質の使用 |
PL3470432T3 (pl) * | 2012-08-21 | 2022-02-07 | Sanofi Biotechnology | Sposoby leczenia lub zapobiegania astmie przez podawanie antagonisty IL-4R |
RU2698907C2 (ru) * | 2012-09-07 | 2019-09-02 | Ридженерон Фармасьютикалз, Инк. | Способы лечения атопического дерматита с помощью антагониста il-4r |
TWI679019B (zh) | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | 抗il-4/抗il-13之雙特異性抗體調配物 |
WO2015121318A1 (en) | 2014-02-12 | 2015-08-20 | Sanofi | Anti-il-4/anti-il-13 bispecific antibody/polyglutamate formulations |
TWI745962B (zh) | 2014-06-27 | 2021-11-11 | 法商賽諾菲公司 | 測定投予至人類個體之包括雙-v-區類抗體蛋白或其片段的劑量是否在人類個體中與il-4或il-13特異性結合之方法 |
-
2015
- 2015-06-25 TW TW109115991A patent/TWI745962B/zh active
- 2015-06-25 TW TW104120426A patent/TW201628647A/zh unknown
- 2015-06-26 WO PCT/IB2015/001377 patent/WO2015198146A2/en active Application Filing
- 2015-06-26 CR CR20170022A patent/CR20170022A/es unknown
- 2015-06-26 NZ NZ728020A patent/NZ728020A/en unknown
- 2015-06-26 EA EA201692495A patent/EA201692495A8/ru unknown
- 2015-06-26 KR KR1020177002123A patent/KR102558891B1/ko active IP Right Grant
- 2015-06-26 EP EP15775787.3A patent/EP3160502A2/en active Pending
- 2015-06-26 US US15/320,106 patent/US20170145089A1/en not_active Abandoned
- 2015-06-26 SG SG11201610594WA patent/SG11201610594WA/en unknown
- 2015-06-26 AU AU2015278829A patent/AU2015278829B2/en active Active
- 2015-06-26 TN TN2016000569A patent/TN2016000569A1/en unknown
- 2015-06-26 MX MX2017000171A patent/MX2017000171A/es unknown
- 2015-06-26 SG SG10201811562YA patent/SG10201811562YA/en unknown
- 2015-06-26 JP JP2016575577A patent/JP2017530089A/ja active Pending
- 2015-06-26 CA CA2952902A patent/CA2952902C/en active Active
- 2015-06-26 BR BR112016030568A patent/BR112016030568B8/pt active IP Right Grant
- 2015-06-26 CN CN201580045437.XA patent/CN106573975A/zh active Pending
-
2016
- 2016-12-21 PH PH12016502569A patent/PH12016502569A1/en unknown
- 2016-12-23 CL CL2016003317A patent/CL2016003317A1/es unknown
-
2019
- 2019-03-08 US US16/297,419 patent/US11136388B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2952902C (en) | 2024-02-13 |
WO2015198146A3 (en) | 2016-03-31 |
PH12016502569A1 (en) | 2017-04-17 |
MX2017000171A (es) | 2017-04-25 |
JP2017530089A (ja) | 2017-10-12 |
EA201692495A8 (ru) | 2017-07-31 |
US20190359703A1 (en) | 2019-11-28 |
CL2016003317A1 (es) | 2017-08-11 |
US20170145089A1 (en) | 2017-05-25 |
CA2952902A1 (en) | 2015-12-30 |
SG11201610594WA (en) | 2017-01-27 |
SG10201811562YA (en) | 2019-01-30 |
TN2016000569A1 (en) | 2018-04-04 |
TWI745962B (zh) | 2021-11-11 |
BR112016030568B1 (pt) | 2023-10-17 |
EA201692495A1 (ru) | 2017-05-31 |
WO2015198146A2 (en) | 2015-12-30 |
TW201628647A (zh) | 2016-08-16 |
NZ728020A (en) | 2022-07-01 |
EP3160502A2 (en) | 2017-05-03 |
BR112016030568B8 (pt) | 2023-12-05 |
AU2015278829B2 (en) | 2021-03-25 |
KR102558891B1 (ko) | 2023-07-21 |
CN106573975A (zh) | 2017-04-19 |
KR20170020519A (ko) | 2017-02-22 |
BR112016030568A2 (pt) | 2018-02-20 |
TW202034954A (zh) | 2020-10-01 |
US11136388B2 (en) | 2021-10-05 |
AU2015278829A1 (en) | 2017-02-02 |
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