CR20160348A - Compuestos - Google Patents

Compuestos

Info

Publication number
CR20160348A
CR20160348A CR20160348A CR20160348A CR20160348A CR 20160348 A CR20160348 A CR 20160348A CR 20160348 A CR20160348 A CR 20160348A CR 20160348 A CR20160348 A CR 20160348A CR 20160348 A CR20160348 A CR 20160348A
Authority
CR
Costa Rica
Prior art keywords
disease
activity
compounds
lrrk2 kinases
lrrk2
Prior art date
Application number
CR20160348A
Other languages
English (en)
Spanish (es)
Inventor
Xiao; Ding
Colin Michael Edge
Yingxia; Sang
Baowei; Zhao
Qian; Liu
Luigi Piero Stasi
Zehong; Wan
Original Assignee
Glaxosmithline Intellectual Property Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithline Intellectual Property Dev Ltd filed Critical Glaxosmithline Intellectual Property Dev Ltd
Publication of CR20160348A publication Critical patent/CR20160348A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CR20160348A 2014-01-29 2015-01-28 Compuestos CR20160348A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2014000139 2014-01-29
PCT/CN2015/000055 WO2015113452A1 (en) 2014-01-29 2015-01-28 Compounds

Publications (1)

Publication Number Publication Date
CR20160348A true CR20160348A (es) 2017-04-28

Family

ID=53756224

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160348A CR20160348A (es) 2014-01-29 2015-01-28 Compuestos

Country Status (20)

Country Link
US (2) US10087186B2 (enExample)
EP (1) EP3099695B1 (enExample)
JP (1) JP6422986B2 (enExample)
KR (1) KR20160106622A (enExample)
CN (1) CN105940004B (enExample)
AU (2) AU2015210593A1 (enExample)
CA (1) CA2937431A1 (enExample)
CL (1) CL2016001895A1 (enExample)
CR (1) CR20160348A (enExample)
DO (2) DOP2016000195A (enExample)
EA (1) EA029774B1 (enExample)
ES (1) ES2802174T3 (enExample)
IL (1) IL246579B (enExample)
MA (1) MA39219B1 (enExample)
MX (1) MX367370B (enExample)
PE (1) PE20161443A1 (enExample)
PH (1) PH12016501307A1 (enExample)
SG (1) SG11201605342UA (enExample)
UA (1) UA118369C2 (enExample)
WO (1) WO2015113452A1 (enExample)

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CN105348270B (zh) * 2015-11-09 2018-01-09 吕显艳 一种防治牙体牙髓感染的药物组合物
US11214565B2 (en) 2015-11-20 2022-01-04 Denali Therapeutics Inc. Compound, compositions, and methods
CN108934162A (zh) 2015-12-16 2018-12-04 南方研究所 吡咯并嘧啶化合物、作为激酶lrrk2抑制剂的用途及其制备方法
CN105418616B (zh) * 2015-12-26 2018-01-12 山东大学 一种含有 4‑氨基吡唑结构的jak 激酶抑制剂及其制备方法和应用
US11028080B2 (en) 2016-03-11 2021-06-08 Denali Therapeutics Inc. Substituted pyrimidines as LRKK2 inhibitors
PT3472153T (pt) 2016-06-16 2021-12-31 Denali Therapeutics Inc Pirimidin-2-ilamino-1h-pirazóis como inibidores de lrrk2 para uso no tratamento de distúrbios neurodegenerativos
EP3573956A4 (en) * 2017-01-25 2020-08-12 GlaxoSmithKline Intellectual Property Management Limited COMPOUNDS
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FI3604304T3 (fi) 2017-03-23 2022-12-15 Pyrrolopyridiinijohdannaisyhdiste, menetelmä sen valmistamiseksi ja sitä vaikuttavana ainesosana sisältävä farmaseuttinen koostumus proteiinikinaasiin liittyvien tautien ehkäisemiseksi tai hoitamiseksi
JP7230053B2 (ja) * 2017-12-05 2023-02-28 オスコテック インコーポレイテッド Ｌｒｒｋ２阻害剤としてのピロロ（ピラゾロ）ピリミジン誘導体
CN108715834B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种富含cd41+、cd81+微囊的血小板裂解液制备方法
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JP7447098B2 (ja) * 2018-09-25 2024-03-11 カーデュリオン・ファーマシューティカルズ・インコーポレイテッド アミノピリミジン化合物
EP3915985A4 (en) 2019-01-18 2022-09-28 Voronoi Co., Ltd. PYRROLOPYRIDE DERIVATIVE AND USE THEREOF FOR THE PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED DISEASES
CZ308800B6 (cs) 2019-02-12 2021-05-26 Univerzita Palackého v Olomouci Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci
AU2021371136A1 (en) 2020-10-29 2023-05-11 Merck Sharp & Dohme Llc N-linked isoquinoline amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
AU2021371697B2 (en) * 2020-10-29 2024-10-24 Suzhou Yabao Pharmaceutical R&D Co., Ltd. Substituted diarylamine compound, pharmaceutical composition thereof, preparation method therefor, and use thereof
KR20220081631A (ko) 2020-12-09 2022-06-16 보로노이 주식회사 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도
WO2023073013A1 (en) 2021-10-27 2023-05-04 H. Lundbeck A/S Lrrk2 inhibitors
WO2023076404A1 (en) 2021-10-27 2023-05-04 Aria Pharmaceuticals, Inc. Methods for treating systemic lupus erythematosus
US11958865B1 (en) 2022-09-15 2024-04-16 H. Lundbeck A/S Leucine-rich repeat kinase 2 (LRRK2) inhibitors

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WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
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RU2016134751A (ru) 2014-01-29 2018-03-02 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Соединения
SG11201605342UA (en) 2014-01-29 2016-08-30 Glaxosmithkline Ip Dev Ltd Compounds

Also Published As

Publication number Publication date
MA39219A1 (fr) 2017-09-29
ES2802174T3 (es) 2021-01-15
EA029774B1 (ru) 2018-05-31
PE20161443A1 (es) 2017-01-06
WO2015113452A1 (en) 2015-08-06
JP6422986B2 (ja) 2018-11-14
JP2017504631A (ja) 2017-02-09
MX367370B (es) 2019-08-16
MX2016009893A (es) 2016-10-31
EP3099695A1 (en) 2016-12-07
CA2937431A1 (en) 2015-08-06
US10087186B2 (en) 2018-10-02
DOP2019000010A (es) 2019-03-15
AU2018200277B2 (en) 2019-09-26
EA201691514A1 (ru) 2016-12-30
EP3099695A4 (en) 2017-07-12
MA39219B1 (fr) 2018-11-30
IL246579B (en) 2019-05-30
UA118369C2 (uk) 2019-01-10
IL246579A0 (en) 2016-08-31
DOP2016000195A (es) 2016-10-31
US10618901B2 (en) 2020-04-14
AU2015210593A1 (en) 2016-07-07
US20170015668A1 (en) 2017-01-19
PH12016501307B1 (en) 2016-08-15
EP3099695B1 (en) 2020-04-08
US20180354956A1 (en) 2018-12-13
PH12016501307A1 (en) 2016-08-15
CL2016001895A1 (es) 2016-12-09
CN105940004A (zh) 2016-09-14
KR20160106622A (ko) 2016-09-12
CN105940004B (zh) 2018-02-02
AU2018200277A1 (en) 2018-02-01
SG11201605342UA (en) 2016-08-30

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