CR20160348A - Compuestos - Google Patents

Compuestos

Info

Publication number
CR20160348A
CR20160348A CR20160348A CR20160348A CR20160348A CR 20160348 A CR20160348 A CR 20160348A CR 20160348 A CR20160348 A CR 20160348A CR 20160348 A CR20160348 A CR 20160348A CR 20160348 A CR20160348 A CR 20160348A
Authority
CR
Costa Rica
Prior art keywords
disease
activity
compounds
lrrk2 kinases
lrrk2
Prior art date
Application number
CR20160348A
Other languages
English (en)
Spanish (es)
Inventor
Xiao; Ding
Colin Michael Edge
Yingxia; Sang
Baowei; Zhao
Qian; Liu
Luigi Piero Stasi
Zehong; Wan
Original Assignee
Glaxosmithline Intellectual Property Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithline Intellectual Property Dev Ltd filed Critical Glaxosmithline Intellectual Property Dev Ltd
Publication of CR20160348A publication Critical patent/CR20160348A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CR20160348A 2014-01-29 2015-01-28 Compuestos CR20160348A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2014000139 2014-01-29
PCT/CN2015/000055 WO2015113452A1 (en) 2014-01-29 2015-01-28 Compounds

Publications (1)

Publication Number Publication Date
CR20160348A true CR20160348A (es) 2017-04-28

Family

ID=53756224

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160348A CR20160348A (es) 2014-01-29 2015-01-28 Compuestos

Country Status (20)

Country Link
US (2) US10087186B2 (enExample)
EP (1) EP3099695B1 (enExample)
JP (1) JP6422986B2 (enExample)
KR (1) KR20160106622A (enExample)
CN (1) CN105940004B (enExample)
AU (2) AU2015210593A1 (enExample)
CA (1) CA2937431A1 (enExample)
CL (1) CL2016001895A1 (enExample)
CR (1) CR20160348A (enExample)
DO (2) DOP2016000195A (enExample)
EA (1) EA029774B1 (enExample)
ES (1) ES2802174T3 (enExample)
IL (1) IL246579B (enExample)
MA (1) MA39219B1 (enExample)
MX (1) MX367370B (enExample)
PE (1) PE20161443A1 (enExample)
PH (1) PH12016501307A1 (enExample)
SG (1) SG11201605342UA (enExample)
UA (1) UA118369C2 (enExample)
WO (1) WO2015113452A1 (enExample)

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US10087186B2 (en) 2014-01-29 2018-10-02 Glaxosmithkline Intellectual Property Development Limited Compounds as LRRK2 kinase inhibitors
CN105153131B (zh) * 2015-09-21 2017-10-17 马彦丽 一种在护理上治疗人神经胶质瘤的药物组合物
CN105348270B (zh) * 2015-11-09 2018-01-09 吕显艳 一种防治牙体牙髓感染的药物组合物
US11214565B2 (en) 2015-11-20 2022-01-04 Denali Therapeutics Inc. Compound, compositions, and methods
CN108934162A (zh) 2015-12-16 2018-12-04 南方研究所 吡咯并嘧啶化合物、作为激酶lrrk2抑制剂的用途及其制备方法
CN105418616B (zh) * 2015-12-26 2018-01-12 山东大学 一种含有 4‑氨基吡唑结构的jak 激酶抑制剂及其制备方法和应用
SI3472153T1 (sl) 2016-06-16 2022-01-31 Denali Therapeutics Inc. Pirimidin-2-ilamino-1H-pirazoli kot zaviralci LRRK2 za uporabo pri zdravljenju nevrodegenerativnih motenj
US10858367B2 (en) 2017-01-25 2020-12-08 Glaxosmithkline Intellectual Property Development Limited Compounds
EP3587422A4 (en) 2017-02-22 2020-05-06 Daegu-Gyeongbuk Medical Innovation Foundation PYRROLOPYRIMIDINE DERIVATIVE COMPOUND, PRODUCTION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION WITH THIS COMPOUND AS AN ACTIVE SUBSTANCE FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE
DK3604304T3 (da) * 2017-03-23 2022-10-31 Daegu Gyeongbuk Medical Innovation Found Pyrrolo-pyridinderivatforbindelse, fremgangsmåde til fremstilling deraf og farmaceutisk sammensætning indeholdende denne som aktiv ingrediens til forebyggelse eller behandling af proteinkinase-relaterede sygdomme
AU2018381574B2 (en) 2017-12-05 2022-09-15 Oscotec Inc. Pyrrolo(pyrazolo)pyrimidine derivative as LRRK2 inhibitor
CN108715834B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种富含cd41+、cd81+微囊的血小板裂解液制备方法
KR20200020622A (ko) * 2018-08-16 2020-02-26 재단법인 대구경북첨단의료산업진흥재단 치환된 헤테로아릴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020068854A1 (en) * 2018-09-25 2020-04-02 Cardurion Pharmaceuticals, Llc Aminopyrimidine compound
EP3915985A4 (en) 2019-01-18 2022-09-28 Voronoi Co., Ltd. PYRROLOPYRIDE DERIVATIVE AND USE THEREOF FOR THE PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED DISEASES
CZ308800B6 (cs) 2019-02-12 2021-05-26 Univerzita Palackého v Olomouci Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci
KR20230091150A (ko) * 2020-10-29 2023-06-22 수저우 야바오 파마슈티걸 알앤디 컴퍼니 리미티드 치환된 디아릴아민 화합물 및 이의 약학적 조성물, 제조 방법과 용도
KR20230097093A (ko) 2020-10-29 2023-06-30 머크 샤프 앤드 돔 엘엘씨 Lrrk2 억제제로서의 n-연결된 이소퀴놀린 아미드, 제약 조성물 및 그의 용도
KR20220081631A (ko) 2020-12-09 2022-06-16 보로노이 주식회사 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도
WO2023076404A1 (en) 2021-10-27 2023-05-04 Aria Pharmaceuticals, Inc. Methods for treating systemic lupus erythematosus
TW202330549A (zh) 2021-10-27 2023-08-01 丹麥商Ｈ 朗德貝克公司 Lrrk2抑制劑
WO2024056775A1 (en) 2022-09-15 2024-03-21 H. Lundbeck A/S Macrocyclic leucine-rich repeat kinase 2 (lrrk2) inhibitors

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US8778939B2 (en) * 2009-09-29 2014-07-15 Glaxo Group Limited Compounds
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
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CN105732639A (zh) 2012-06-29 2016-07-06 辉瑞大药厂 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类
ES2717757T3 (es) 2014-01-29 2019-06-25 Glaxosmithkline Ip Dev Ltd Compuestos
US10087186B2 (en) 2014-01-29 2018-10-02 Glaxosmithkline Intellectual Property Development Limited Compounds as LRRK2 kinase inhibitors

Also Published As

Publication number Publication date
IL246579A0 (en) 2016-08-31
EA029774B1 (ru) 2018-05-31
AU2015210593A1 (en) 2016-07-07
JP2017504631A (ja) 2017-02-09
MA39219B1 (fr) 2018-11-30
EP3099695A1 (en) 2016-12-07
UA118369C2 (uk) 2019-01-10
MX2016009893A (es) 2016-10-31
EA201691514A1 (ru) 2016-12-30
ES2802174T3 (es) 2021-01-15
CL2016001895A1 (es) 2016-12-09
KR20160106622A (ko) 2016-09-12
DOP2016000195A (es) 2016-10-31
US20170015668A1 (en) 2017-01-19
AU2018200277B2 (en) 2019-09-26
PH12016501307B1 (en) 2016-08-15
CA2937431A1 (en) 2015-08-06
IL246579B (en) 2019-05-30
PE20161443A1 (es) 2017-01-06
MX367370B (es) 2019-08-16
US20180354956A1 (en) 2018-12-13
US10618901B2 (en) 2020-04-14
PH12016501307A1 (en) 2016-08-15
AU2018200277A1 (en) 2018-02-01
CN105940004A (zh) 2016-09-14
SG11201605342UA (en) 2016-08-30
JP6422986B2 (ja) 2018-11-14
DOP2019000010A (es) 2019-03-15
CN105940004B (zh) 2018-02-02
EP3099695A4 (en) 2017-07-12
US10087186B2 (en) 2018-10-02
EP3099695B1 (en) 2020-04-08
WO2015113452A1 (en) 2015-08-06
MA39219A1 (fr) 2017-09-29

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