CR20120623A - Composiciones Farmacéuticas que comprenden Monohidrato de Lactato de 4-amino-5-Fluoro-3-[6-(4-Metil-Piperazin-1-Il)-1H- Bencimidazol-2-Il]-1H-Quinolin-2-Ona - Google Patents
Composiciones Farmacéuticas que comprenden Monohidrato de Lactato de 4-amino-5-Fluoro-3-[6-(4-Metil-Piperazin-1-Il)-1H- Bencimidazol-2-Il]-1H-Quinolin-2-OnaInfo
- Publication number
- CR20120623A CR20120623A CR20120623A CR20120623A CR20120623A CR 20120623 A CR20120623 A CR 20120623A CR 20120623 A CR20120623 A CR 20120623A CR 20120623 A CR20120623 A CR 20120623A CR 20120623 A CR20120623 A CR 20120623A
- Authority
- CR
- Costa Rica
- Prior art keywords
- benzimidazol
- quinolin
- piperazin
- fluoro
- amino
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- AEEGSXBXXSNVIR-UHFFFAOYSA-N O.OC(C(=O)O)C.N1C(C=CC2=CC=CC=C12)=O Chemical compound O.OC(C(=O)O)C.N1C(C=CC2=CC=CC=C12)=O AEEGSXBXXSNVIR-UHFFFAOYSA-N 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una composición farmacéutica para su administración oral, la cual comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1H-bencimidazol-2-il]-1H-quinolin-2-ona,un relleno en una cantidad del 15 al 70 por ciento en peso, un desintegrante en una cantidad de menos del 15 por ciento en peso, un derrapante y/o un lubricante en una cantidad del 0.1 al 10 por ciento en peso, en donde las cantidades en peso se basan en el peso total de la composición.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10168028 | 2010-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20120623A true CR20120623A (es) | 2013-02-11 |
Family
ID=42751565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20120623A CR20120623A (es) | 2010-06-30 | 2012-12-11 | Composiciones Farmacéuticas que comprenden Monohidrato de Lactato de 4-amino-5-Fluoro-3-[6-(4-Metil-Piperazin-1-Il)-1H- Bencimidazol-2-Il]-1H-Quinolin-2-Ona |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9545402B2 (es) |
| EP (2) | EP2588086B1 (es) |
| JP (1) | JP6043281B2 (es) |
| KR (2) | KR101840182B1 (es) |
| CN (2) | CN106943355B (es) |
| AR (1) | AR081776A1 (es) |
| AU (1) | AU2011273519B2 (es) |
| BR (1) | BR112012033479A8 (es) |
| CA (1) | CA2801826C (es) |
| CL (1) | CL2012003729A1 (es) |
| CO (1) | CO6650354A2 (es) |
| CR (1) | CR20120623A (es) |
| CU (1) | CU20120177A7 (es) |
| DK (1) | DK2588086T3 (es) |
| DO (1) | DOP2012000324A (es) |
| EA (1) | EA026244B1 (es) |
| EC (1) | ECSP13012411A (es) |
| ES (1) | ES2701161T3 (es) |
| GE (1) | GEP20146049B (es) |
| GT (1) | GT201200348A (es) |
| HU (1) | HUE042355T2 (es) |
| IL (1) | IL223799A (es) |
| MA (1) | MA34387B1 (es) |
| MX (1) | MX345404B (es) |
| MY (2) | MY163369A (es) |
| NI (1) | NI201200189A (es) |
| NZ (1) | NZ604055A (es) |
| PE (1) | PE20130481A1 (es) |
| PL (1) | PL2588086T3 (es) |
| PT (1) | PT2588086T (es) |
| SG (1) | SG186182A1 (es) |
| TN (1) | TN2012000574A1 (es) |
| TR (1) | TR201818761T4 (es) |
| TW (1) | TWI583384B (es) |
| UA (1) | UA109659C2 (es) |
| UY (1) | UY33472A (es) |
| WO (1) | WO2012001074A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013063003A1 (en) | 2011-10-28 | 2013-05-02 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
| KR20140117457A (ko) | 2012-01-31 | 2014-10-07 | 노파르티스 아게 | Rtk 억제제와 항에스트로겐의 조합물 및 암의 치료를 위한 그의 용도 |
| US20150202203A1 (en) | 2012-07-11 | 2015-07-23 | Novartis Ag | Method of Treating Gastrointestinal Stromal Tumors |
| US9395468B2 (en) | 2012-08-27 | 2016-07-19 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
| WO2014058785A1 (en) | 2012-10-10 | 2014-04-17 | Novartis Ag | Combination therapy |
| AU2014240404B2 (en) * | 2013-03-14 | 2016-07-21 | Societe Des Produits Nestle S.A. | Manufacture of peanut formulations for oral desensitization |
| WO2014159609A1 (en) * | 2013-03-14 | 2014-10-02 | Allergen Research Corporation | Peanut formulations and uses thereof |
| EP3988992A1 (en) | 2013-11-15 | 2022-04-27 | Tangible Science, Inc. | Contact lens with a hydrophilic layer |
| WO2015187736A1 (en) * | 2014-06-02 | 2015-12-10 | Allergen Research Corporation | Placebo formulations and uses thereof |
| CN107206119B (zh) | 2014-12-09 | 2021-01-29 | 实体科学公司 | 具有生物相容性层的医疗设备涂层 |
| TWI829098B (zh) | 2015-01-02 | 2024-01-11 | 美商梅拉洛伊卡公司 | 細菌組成物 |
| JP2021501763A (ja) | 2017-11-02 | 2021-01-21 | アイミューン セラピューティクス，インコーポレイテッド | 経口免疫療法の方法 |
| WO2020231843A1 (en) | 2019-05-10 | 2020-11-19 | Aimmune Therapeutics, Inc. | Methods for improving the quality of life of a patient with a peanut allergy |
| US10835531B1 (en) | 2019-06-18 | 2020-11-17 | Oncology Venture ApS | Methods for predicting drug responsiveness in cancer patients |
| US20230302139A1 (en) * | 2020-07-31 | 2023-09-28 | University Of Florida Research Foundation, Incorporated | Targeted rna degradation allows precision repurposing of protein-targeted small molecule medicines to rna |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5009897A (en) * | 1988-06-24 | 1991-04-23 | Abbott Laboratories | Pharmaceutical granules and tablets made therefrom |
| DE60132937T2 (de) | 2000-09-11 | 2009-02-12 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zur Herstellung von Benzimidazol-2-yl -Chinolinonderivaten |
| JP4613130B2 (ja) | 2002-08-23 | 2011-01-12 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | ベンゾイミダゾールキノリノンおよびそれらの使用 |
| US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
| GB0504203D0 (en) * | 2005-03-01 | 2005-04-06 | Novartis Ag | Organic compounds |
| CN101218228A (zh) * | 2005-05-23 | 2008-07-09 | 诺瓦提斯公司 | 4-氨基-5-氟-3-[6-(4-甲基哌嗪-1-基)-1h-苯并咪唑-2-基]-1h-喹啉-2-酮乳酸盐的结晶和其它形式 |
| EA200800360A1 (ru) * | 2005-07-22 | 2008-06-30 | Мириад Дженетикс, Инк. | Формуляции с высоким содержанием лекарства и дозированные формы |
| CN101316593B (zh) * | 2005-11-29 | 2012-05-02 | 诺瓦提斯公司 | 喹啉酮类的制剂 |
| EP2772257A1 (en) * | 2005-11-29 | 2014-09-03 | Novartis AG | Formulations of quinolinones |
| CL2008000681A1 (es) | 2007-03-09 | 2008-10-24 | Novartis Ag | Metodo de tratamiento de melanoma mediante el uso de compuestos derivados de 4-amino-5-fluoro-(benzoimidazol sustituido)-1h-quinolin-2-ona. |
| ES2436266T3 (es) | 2007-11-08 | 2013-12-30 | Ambit Biosciences Corporation | Métodos para administrar N-(5-terc-butil-isoxazol-3-il)-N'-{4-[7-(2-morfolin-4-il-etoxi)imidazo[2,1-b][1,3]benzotiazol-2-il]fenil}urea para tratar enfermedades proliferativas |
| AR070924A1 (es) | 2008-03-19 | 2010-05-12 | Novartis Ag | Formas cristalinas y dos formas solvatadas de sales del acido lactico de 4- amino -5- fluoro-3-(5-(4-metilpiperazin-1-il ) -1h- bencimidazol-2-il) quinolin -2-(1h) - ona |
| EP2108365A1 (en) * | 2008-04-09 | 2009-10-14 | LEK Pharmaceuticals d.d. | Single dosage pharmaceutical formulation comprising eprosartan mesylate |
| NZ602807A (en) | 2010-04-16 | 2014-02-28 | Novartis Ag | 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one and an mtor inhibitor |
-
2011
- 2011-06-28 AR ARP110102271A patent/AR081776A1/es unknown
- 2011-06-28 UY UY0001033472A patent/UY33472A/es not_active Application Discontinuation
- 2011-06-29 CA CA2801826A patent/CA2801826C/en active Active
- 2011-06-29 ES ES11734043T patent/ES2701161T3/es active Active
- 2011-06-29 PT PT11734043T patent/PT2588086T/pt unknown
- 2011-06-29 TR TR2018/18761T patent/TR201818761T4/tr unknown
- 2011-06-29 CN CN201710208616.1A patent/CN106943355B/zh active Active
- 2011-06-29 TW TW100122927A patent/TWI583384B/zh not_active IP Right Cessation
- 2011-06-29 EP EP11734043.0A patent/EP2588086B1/en active Active
- 2011-06-29 HU HUE11734043A patent/HUE042355T2/hu unknown
- 2011-06-29 BR BR112012033479A patent/BR112012033479A8/pt not_active Application Discontinuation
- 2011-06-29 EA EA201291410A patent/EA026244B1/ru not_active IP Right Cessation
- 2011-06-29 MX MX2012015091A patent/MX345404B/es active IP Right Grant
- 2011-06-29 NZ NZ604055A patent/NZ604055A/en not_active IP Right Cessation
- 2011-06-29 MY MYPI2012005339A patent/MY163369A/en unknown
- 2011-06-29 SG SG2012089413A patent/SG186182A1/en unknown
- 2011-06-29 JP JP2013517282A patent/JP6043281B2/ja active Active
- 2011-06-29 EP EP18193864.8A patent/EP3446686A1/en active Pending
- 2011-06-29 PL PL11734043T patent/PL2588086T3/pl unknown
- 2011-06-29 CN CN2011800320095A patent/CN103068373A/zh active Pending
- 2011-06-29 GE GEAP201112986A patent/GEP20146049B/en unknown
- 2011-06-29 AU AU2011273519A patent/AU2011273519B2/en active Active
- 2011-06-29 MA MA35575A patent/MA34387B1/fr unknown
- 2011-06-29 KR KR1020177035178A patent/KR101840182B1/ko active IP Right Grant
- 2011-06-29 KR KR1020137002390A patent/KR20130091319A/ko not_active Application Discontinuation
- 2011-06-29 PE PE2012002517A patent/PE20130481A1/es not_active Application Discontinuation
- 2011-06-29 UA UAA201213966A patent/UA109659C2/uk unknown
- 2011-06-29 DK DK11734043.0T patent/DK2588086T3/en active
- 2011-06-29 WO PCT/EP2011/060949 patent/WO2012001074A2/en active Application Filing
- 2011-06-29 US US13/703,120 patent/US9545402B2/en active Active
- 2011-11-29 MY MYPI2016002052A patent/MY177741A/en unknown
-
2012
- 2012-12-05 TN TNP2012000574A patent/TN2012000574A1/en unknown
- 2012-12-11 CR CR20120623A patent/CR20120623A/es unknown
- 2012-12-20 IL IL223799A patent/IL223799A/en active IP Right Grant
- 2012-12-20 NI NI201200189A patent/NI201200189A/es unknown
- 2012-12-21 GT GT201200348A patent/GT201200348A/es unknown
- 2012-12-21 DO DO2012000324A patent/DOP2012000324A/es unknown
- 2012-12-24 CU CU2012000177A patent/CU20120177A7/es unknown
- 2012-12-27 CO CO12234898A patent/CO6650354A2/es not_active Application Discontinuation
- 2012-12-28 CL CL2012003729A patent/CL2012003729A1/es unknown
-
2013
- 2013-01-30 EC ECSP13012411 patent/ECSP13012411A/es unknown
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