CO6880065A2 - Nuevos compuestos de 4-piperidinilo para uso como inhibidores de la tankirasa - Google Patents

Nuevos compuestos de 4-piperidinilo para uso como inhibidores de la tankirasa

Info

Publication number
CO6880065A2
CO6880065A2 CO14031176A CO14031176A CO6880065A2 CO 6880065 A2 CO6880065 A2 CO 6880065A2 CO 14031176 A CO14031176 A CO 14031176A CO 14031176 A CO14031176 A CO 14031176A CO 6880065 A2 CO6880065 A2 CO 6880065A2
Authority
CO
Colombia
Prior art keywords
tankirase
inhibitors
new
piperidinyl compounds
piperidinyl
Prior art date
Application number
CO14031176A
Other languages
English (en)
Spanish (es)
Inventor
Christine Hiu-Tung Chen
Noel Chin Chin
Lucian V Dipietro
Jianme Fan
Mark G Palermo
Michael David Shultz
Bakary Barry Toure
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6880065A2 publication Critical patent/CO6880065A2/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CO14031176A 2011-07-13 2014-02-13 Nuevos compuestos de 4-piperidinilo para uso como inhibidores de la tankirasa CO6880065A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161507321P 2011-07-13 2011-07-13

Publications (1)

Publication Number Publication Date
CO6880065A2 true CO6880065A2 (es) 2014-02-28

Family

ID=46604017

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14031176A CO6880065A2 (es) 2011-07-13 2014-02-13 Nuevos compuestos de 4-piperidinilo para uso como inhibidores de la tankirasa

Country Status (21)

Country Link
US (2) US9163003B2 (cg-RX-API-DMAC7.html)
EP (1) EP2731940B1 (cg-RX-API-DMAC7.html)
JP (1) JP5957077B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140051944A (cg-RX-API-DMAC7.html)
CN (1) CN103797006B (cg-RX-API-DMAC7.html)
AP (1) AP2014007400A0 (cg-RX-API-DMAC7.html)
AU (1) AU2012282076A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014000792A2 (cg-RX-API-DMAC7.html)
CA (1) CA2841932A1 (cg-RX-API-DMAC7.html)
CO (1) CO6880065A2 (cg-RX-API-DMAC7.html)
CR (1) CR20140071A (cg-RX-API-DMAC7.html)
DO (1) DOP2014000012A (cg-RX-API-DMAC7.html)
EA (1) EA201490272A1 (cg-RX-API-DMAC7.html)
ES (1) ES2548513T3 (cg-RX-API-DMAC7.html)
IL (1) IL230430A0 (cg-RX-API-DMAC7.html)
MA (1) MA35342B1 (cg-RX-API-DMAC7.html)
MX (1) MX2014000536A (cg-RX-API-DMAC7.html)
PH (1) PH12014500126A1 (cg-RX-API-DMAC7.html)
TN (1) TN2014000016A1 (cg-RX-API-DMAC7.html)
WO (1) WO2013008217A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201400374B (cg-RX-API-DMAC7.html)

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CA2865511A1 (en) 2012-03-07 2013-09-12 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
MX364438B (es) * 2013-03-15 2019-04-26 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
LT3030554T (lt) * 2013-08-07 2018-05-10 Merck Patent Gmbh Piperidin-karbamido dariniai
US9611223B2 (en) 2013-09-11 2017-04-04 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
WO2015135461A1 (zh) * 2014-03-10 2015-09-17 四川海思科制药有限公司 取代的二氢苯并呋喃-哌啶-甲酮衍生物、其制备及用途
MX2016014436A (es) 2014-05-07 2017-01-23 Merck Patent Gmbh Derivados de heterociclil-butanamida.
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
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WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
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CA3121697A1 (en) 2018-12-03 2020-06-11 Merck Patent Gmbh 4-heteroarylcarbonyl-n-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases
JP7407461B2 (ja) 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ras病、及び線維性疾患の処置のためのrasスーパーファミリーと相互作用する化合物
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Also Published As

Publication number Publication date
WO2013008217A1 (en) 2013-01-17
CN103797006A (zh) 2014-05-14
MA35342B1 (fr) 2014-08-01
TN2014000016A1 (en) 2015-07-01
PH12014500126A1 (en) 2014-02-24
EP2731940A1 (en) 2014-05-21
BR112014000792A2 (pt) 2017-10-31
IL230430A0 (en) 2014-03-31
US9163003B2 (en) 2015-10-20
CR20140071A (es) 2014-10-16
JP2014522855A (ja) 2014-09-08
AP2014007400A0 (en) 2014-01-31
EP2731940B1 (en) 2015-08-19
CA2841932A1 (en) 2013-01-17
AU2012282076A1 (en) 2014-02-27
MX2014000536A (es) 2014-12-05
CN103797006B (zh) 2016-01-27
ZA201400374B (en) 2014-10-29
EA201490272A1 (ru) 2014-05-30
USRE46942E1 (en) 2018-07-10
US20150126513A1 (en) 2015-05-07
DOP2014000012A (es) 2014-07-31
NZ620426A (en) 2015-08-28
ES2548513T3 (es) 2015-10-19
KR20140051944A (ko) 2014-05-02
JP5957077B2 (ja) 2016-07-27

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