CO6551754A2 - 7-[3.5-dihidroxi-2-(3-hidrixi-5-fenil-pent-1-enil)- ciclopentil] -n-etil-hept-5-enamida(bimatoprost) en forma cristalina ii, mètodos para la preparaciòn y mètodo para su uso - Google Patents
7-[3.5-dihidroxi-2-(3-hidrixi-5-fenil-pent-1-enil)- ciclopentil] -n-etil-hept-5-enamida(bimatoprost) en forma cristalina ii, mètodos para la preparaciòn y mètodo para su usoInfo
- Publication number
- CO6551754A2 CO6551754A2 CO12104940A CO12104940A CO6551754A2 CO 6551754 A2 CO6551754 A2 CO 6551754A2 CO 12104940 A CO12104940 A CO 12104940A CO 12104940 A CO12104940 A CO 12104940A CO 6551754 A2 CO6551754 A2 CO 6551754A2
- Authority
- CO
- Colombia
- Prior art keywords
- bimatoprost
- pent
- hept
- phenyl
- hidrixi
- Prior art date
Links
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 title abstract 3
- 229960002470 bimatoprost Drugs 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 title 1
- AQOKCDNYWBIDND-UHFFFAOYSA-N 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-enyl)cyclopentyl]-n-ethylhept-5-enamide Chemical compound CCNC(=O)CCCC=CCC1C(O)CC(O)C1C=CC(O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/39—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26347109P | 2009-11-23 | 2009-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6551754A2 true CO6551754A2 (es) | 2012-10-31 |
Family
ID=43639099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12104940A CO6551754A2 (es) | 2009-11-23 | 2012-06-22 | 7-[3.5-dihidroxi-2-(3-hidrixi-5-fenil-pent-1-enil)- ciclopentil] -n-etil-hept-5-enamida(bimatoprost) en forma cristalina ii, mètodos para la preparaciòn y mètodo para su uso |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8629185B2 (enExample) |
| EP (1) | EP2504313A1 (enExample) |
| JP (2) | JP5921439B2 (enExample) |
| KR (1) | KR20120085330A (enExample) |
| CN (2) | CN102712584B (enExample) |
| AU (1) | AU2010321831B2 (enExample) |
| BR (1) | BR112012012387A2 (enExample) |
| CA (1) | CA2781698A1 (enExample) |
| CL (1) | CL2012001339A1 (enExample) |
| CO (1) | CO6551754A2 (enExample) |
| HK (1) | HK1207570A1 (enExample) |
| IL (2) | IL219959A (enExample) |
| IN (1) | IN2012DN05209A (enExample) |
| MX (1) | MX2012005968A (enExample) |
| NZ (1) | NZ600263A (enExample) |
| PH (1) | PH12012501098A1 (enExample) |
| RU (1) | RU2577546C2 (enExample) |
| UA (1) | UA110696C2 (enExample) |
| WO (1) | WO2011063276A1 (enExample) |
| ZA (1) | ZA201203883B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12012501098A1 (en) * | 2009-11-23 | 2014-10-14 | Allergan Inc | 7-[3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl]-n-ethyl-hept-5-enamide (bimatoprost) in crystalline form ii, methods for preparation, and methods for use thereof |
| PL2723714T3 (pl) | 2011-06-02 | 2018-02-28 | CHINOIN Zrt. | Nowe sposoby otrzymywania amidów prostaglandyn |
| CN104884006B (zh) | 2012-10-26 | 2017-12-15 | 弗赛特影像5股份有限公司 | 用于持续释放药物到眼睛的眼科系统 |
| KR101891144B1 (ko) * | 2012-12-19 | 2018-08-23 | 에스에이알코드 바이오사이언스 인코포레이티드 | Lfa-1 저해제 제형 |
| US9120738B2 (en) | 2012-12-28 | 2015-09-01 | Allergan, Inc. | Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof |
| US9447014B2 (en) | 2012-12-28 | 2016-09-20 | Allergan, Inc. | Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof |
| US10273206B2 (en) | 2014-06-27 | 2019-04-30 | Allergan, Inc. | Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof |
| WO2016168141A1 (en) | 2015-04-13 | 2016-10-20 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
| CN115677549A (zh) * | 2022-10-27 | 2023-02-03 | 神隆医药（常熟）有限公司 | 一种贝美前列素手性异构体的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL143477A (en) * | 2001-05-31 | 2009-07-20 | Finetech Pharmaceutical Ltd | Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives |
| US7166730B2 (en) * | 2000-01-27 | 2007-01-23 | Fine Tech Laboratories, Ltd | Process for the preparation of prostaglandin derivatives |
| AR035651A1 (es) * | 2000-07-28 | 2004-06-23 | Univ Madrid Complutense | Uso de derivados de indol para la manufactura de un medicamento para reducir la presion intraocular y una composicion |
| ES2315737T3 (es) * | 2003-12-30 | 2009-04-01 | Metabolix, Inc. | Agentes nucleantes. |
| IL177762A0 (en) * | 2006-08-29 | 2006-12-31 | Arieh Gutman | Bimatoprost crystalline form i |
| PH12012501098A1 (en) * | 2009-11-23 | 2014-10-14 | Allergan Inc | 7-[3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl]-n-ethyl-hept-5-enamide (bimatoprost) in crystalline form ii, methods for preparation, and methods for use thereof |
-
2010
- 2010-11-19 PH PH1/2012/501098A patent/PH12012501098A1/en unknown
- 2010-11-19 KR KR1020127016191A patent/KR20120085330A/ko not_active Ceased
- 2010-11-19 AU AU2010321831A patent/AU2010321831B2/en active Active
- 2010-11-19 CN CN201080062129.5A patent/CN102712584B/zh active Active
- 2010-11-19 IN IN5209DEN2012 patent/IN2012DN05209A/en unknown
- 2010-11-19 JP JP2012541130A patent/JP5921439B2/ja active Active
- 2010-11-19 WO PCT/US2010/057494 patent/WO2011063276A1/en not_active Ceased
- 2010-11-19 CA CA2781698A patent/CA2781698A1/en not_active Abandoned
- 2010-11-19 BR BR112012012387A patent/BR112012012387A2/pt not_active IP Right Cessation
- 2010-11-19 CN CN201410542159.6A patent/CN104367580A/zh active Pending
- 2010-11-19 UA UAA201207505A patent/UA110696C2/uk unknown
- 2010-11-19 EP EP10785274A patent/EP2504313A1/en not_active Ceased
- 2010-11-19 MX MX2012005968A patent/MX2012005968A/es not_active Application Discontinuation
- 2010-11-19 NZ NZ600263A patent/NZ600263A/en unknown
- 2010-11-19 RU RU2012125185/04A patent/RU2577546C2/ru active
- 2010-11-22 US US12/951,780 patent/US8629185B2/en active Active
-
2012
- 2012-05-23 CL CL2012001339A patent/CL2012001339A1/es unknown
- 2012-05-23 IL IL219959A patent/IL219959A/en active IP Right Grant
- 2012-05-28 ZA ZA2012/03883A patent/ZA201203883B/en unknown
- 2012-06-22 CO CO12104940A patent/CO6551754A2/es unknown
-
2013
- 2013-12-20 US US14/136,323 patent/US9181176B2/en active Active
-
2015
- 2015-07-12 IL IL239892A patent/IL239892A0/en unknown
- 2015-08-25 HK HK15108218.2A patent/HK1207570A1/xx unknown
-
2016
- 2016-02-05 JP JP2016021287A patent/JP2016094471A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140113974A1 (en) | 2014-04-24 |
| RU2577546C2 (ru) | 2016-03-20 |
| AU2010321831A1 (en) | 2012-06-21 |
| CN102712584B (zh) | 2014-10-29 |
| PH12012501098A1 (en) | 2014-10-14 |
| IN2012DN05209A (enExample) | 2015-10-23 |
| NZ600263A (en) | 2014-08-29 |
| AU2010321831B2 (en) | 2016-07-07 |
| JP2016094471A (ja) | 2016-05-26 |
| BR112012012387A2 (pt) | 2019-09-24 |
| CL2012001339A1 (es) | 2012-08-10 |
| UA110696C2 (uk) | 2016-02-10 |
| US8629185B2 (en) | 2014-01-14 |
| CA2781698A1 (en) | 2011-05-26 |
| US20110152376A1 (en) | 2011-06-23 |
| JP5921439B2 (ja) | 2016-05-24 |
| CN104367580A (zh) | 2015-02-25 |
| ZA201203883B (en) | 2013-01-31 |
| US9181176B2 (en) | 2015-11-10 |
| KR20120085330A (ko) | 2012-07-31 |
| WO2011063276A1 (en) | 2011-05-26 |
| IL239892A0 (en) | 2015-08-31 |
| EP2504313A1 (en) | 2012-10-03 |
| MX2012005968A (es) | 2012-08-15 |
| CN102712584A (zh) | 2012-10-03 |
| IL219959A0 (en) | 2012-07-31 |
| RU2012125185A (ru) | 2013-12-27 |
| IL219959A (en) | 2015-07-30 |
| JP2013511573A (ja) | 2013-04-04 |
| HK1207570A1 (en) | 2016-02-05 |
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