ES2530578T3 - Cristales y cristales reticulados de Proteína A y métodos de uso de los mismos - Google Patents

Cristales y cristales reticulados de Proteína A y métodos de uso de los mismos Download PDF

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Publication number
ES2530578T3
ES2530578T3 ES10817707T ES10817707T ES2530578T3 ES 2530578 T3 ES2530578 T3 ES 2530578T3 ES 10817707 T ES10817707 T ES 10817707T ES 10817707 T ES10817707 T ES 10817707T ES 2530578 T3 ES2530578 T3 ES 2530578T3
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Prior art keywords
crystals
protein
cross
methods
linked
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ES10817707T
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English (en)
Inventor
Bhami Shenoy
Reena Patel
Sibyl Baladi
Margaret Mcgrath
Nazar Khalaf
Chanchai Randhawa
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Una composición que comprende forma cristalina reticulada de Proteína A.
ES10817707T 2009-09-15 2010-09-13 Cristales y cristales reticulados de Proteína A y métodos de uso de los mismos Active ES2530578T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24253709P 2009-09-15 2009-09-15
PCT/US2010/048664 WO2011034822A1 (en) 2009-09-15 2010-09-13 Protein a crystals and cross-linked crystals and methods of use thereof

Publications (1)

Publication Number Publication Date
ES2530578T3 true ES2530578T3 (es) 2015-03-03

Family

ID=43758972

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10817707T Active ES2530578T3 (es) 2009-09-15 2010-09-13 Cristales y cristales reticulados de Proteína A y métodos de uso de los mismos

Country Status (12)

Country Link
US (2) US8921531B2 (es)
EP (1) EP2478005B1 (es)
JP (1) JP5700581B2 (es)
KR (1) KR101530417B1 (es)
CN (1) CN102753570B (es)
BR (1) BR112012005869A2 (es)
CA (1) CA2774212C (es)
DK (1) DK2478005T3 (es)
EA (1) EA033141B1 (es)
ES (1) ES2530578T3 (es)
HK (1) HK1173457A1 (es)
WO (1) WO2011034822A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753570B (zh) 2009-09-15 2016-01-20 阿尔泰亚科技公司 A蛋白晶体和交联晶体及其使用方法
JP5963538B2 (ja) * 2012-02-24 2016-08-03 三井造船株式会社 モーレラ属細菌の遺伝子組換え法
JP6147340B2 (ja) * 2013-05-29 2017-06-14 Jsr株式会社 洗浄用組成物、タンパク質精製方法、及びタンパク質
EP2986307A4 (en) 2014-01-03 2017-04-12 Bio-rad Laboratories, Inc. Removal of impurities from protein a eluates
WO2016031932A1 (ja) * 2014-08-27 2016-03-03 田辺三菱製薬株式会社 アルカリ洗浄によるＦｃ領域を有するタンパク質の製造方法
AR103726A1 (es) * 2015-02-27 2017-05-31 Merck Sharp & Dohme Cristales de anticuerpos monoclonales anti-pd-1 humanos
CA3046561A1 (en) * 2016-12-12 2018-06-21 Hurrah S.A R.L. Compositions and methods for increasing the immunoglobulin binding capacities of immunoglobulin-binding polypeptides and oligopeptides
CN110913906A (zh) 2017-05-02 2020-03-24 默沙东公司 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
CN112816700A (zh) * 2020-12-28 2021-05-18 杭州新脉生物科技有限公司 一种检测尿液中hiv抗体的胶体金试纸条

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS508549A (es) 1973-05-21 1975-01-29
DK0861888T3 (da) * 1990-08-03 2006-08-14 Vertex Pharma Anvendelse af tværbundne krystaller som en ny form for immobilisering af enzymer
US5618710A (en) 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
AU628264B2 (en) 1990-08-14 1992-09-10 Oracle International Corporation Methods and apparatus for providing a client interface to an object-oriented invocation of an application
AU2429397A (en) 1996-03-29 1997-10-22 David S. Terman Polymerized staphylococcal protein a for treatment of diseases
US6140475A (en) 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
CN101120017A (zh) * 2004-08-30 2008-02-06 英国龙沙生物医药股份有限公司 用于纯化抗体的亲和力加离子交换层析
CN102753570B (zh) 2009-09-15 2016-01-20 阿尔泰亚科技公司 A蛋白晶体和交联晶体及其使用方法

Also Published As

Publication number Publication date
KR20140002459A (ko) 2014-01-08
EP2478005B1 (en) 2014-11-12
KR101530417B1 (ko) 2015-06-19
CN102753570B (zh) 2016-01-20
HK1173457A1 (zh) 2013-05-16
US8921531B2 (en) 2014-12-30
CA2774212A1 (en) 2011-03-24
CN102753570A (zh) 2012-10-24
EP2478005A1 (en) 2012-07-25
EA033141B1 (ru) 2019-09-30
US20150239962A1 (en) 2015-08-27
EA201270425A1 (ru) 2013-02-28
JP2013504621A (ja) 2013-02-07
EP2478005A4 (en) 2013-07-24
DK2478005T3 (en) 2015-02-16
CA2774212C (en) 2018-01-30
US9273123B2 (en) 2016-03-01
JP5700581B2 (ja) 2015-04-15
WO2011034822A1 (en) 2011-03-24
US20130053548A1 (en) 2013-02-28
BR112012005869A2 (pt) 2017-01-31

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