CO6551737A2 - Anàlogo peptìdico de oxintomodulina - Google Patents

Anàlogo peptìdico de oxintomodulina

Info

Publication number
CO6551737A2
CO6551737A2 CO12104387A CO12104387A CO6551737A2 CO 6551737 A2 CO6551737 A2 CO 6551737A2 CO 12104387 A CO12104387 A CO 12104387A CO 12104387 A CO12104387 A CO 12104387A CO 6551737 A2 CO6551737 A2 CO 6551737A2
Authority
CO
Colombia
Prior art keywords
peptide analog
oxintomoduline
gcgr
oxm
glp
Prior art date
Application number
CO12104387A
Other languages
English (en)
Inventor
Fernandez Jorge Alsina
Wayne David Kohn
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43568014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6551737(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO6551737A2 publication Critical patent/CO6551737A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención comprende un análogo peptídico de Oxintomodulina (OXM) con sustituciones de aminoácido introducidas para optimizar su estabilidad metabólica y modular las actividades de los receptores GcgR/GLP-1R mientras se incrementa su potencia total en el tratamiento de la diabetes y/u obesidad.Este análogo, a su vez, se encuentra PEGilado, para mejorar su tiempo de acción y reducir así la frecuencia de dosificación.
CO12104387A 2009-12-22 2012-06-21 Anàlogo peptìdico de oxintomodulina CO6551737A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28888409P 2009-12-22 2009-12-22
US35256910P 2010-06-08 2010-06-08

Publications (1)

Publication Number Publication Date
CO6551737A2 true CO6551737A2 (es) 2012-10-31

Family

ID=43568014

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12104387A CO6551737A2 (es) 2009-12-22 2012-06-21 Anàlogo peptìdico de oxintomodulina

Country Status (27)

Country Link
US (1) US8415296B2 (es)
EP (1) EP2515927B1 (es)
JP (1) JP5717758B2 (es)
KR (1) KR101399692B1 (es)
CN (1) CN102665752B (es)
AR (1) AR079344A1 (es)
AU (1) AU2010341650B2 (es)
BR (1) BR112012017054A2 (es)
CA (1) CA2784668C (es)
CL (1) CL2012001685A1 (es)
CO (1) CO6551737A2 (es)
CR (1) CR20120339A (es)
DO (1) DOP2012000175A (es)
EA (1) EA201290557A1 (es)
EC (1) ECSP12011988A (es)
ES (1) ES2512141T3 (es)
GT (1) GT201200205A (es)
HK (1) HK1170943A1 (es)
MA (1) MA33826B1 (es)
MX (1) MX2012007449A (es)
NZ (1) NZ600732A (es)
PE (1) PE20121721A1 (es)
SG (1) SG181872A1 (es)
TN (1) TN2012000303A1 (es)
TW (1) TWI451873B (es)
UA (1) UA106399C2 (es)
WO (1) WO2011087671A1 (es)

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Also Published As

Publication number Publication date
US20110152181A1 (en) 2011-06-23
EP2515927B1 (en) 2014-08-06
PE20121721A1 (es) 2012-12-17
EP2515927A1 (en) 2012-10-31
CL2012001685A1 (es) 2012-11-23
ECSP12011988A (es) 2012-07-31
CR20120339A (es) 2012-10-02
JP5717758B2 (ja) 2015-05-13
AR079344A1 (es) 2012-01-18
CN102665752B (zh) 2015-01-21
CA2784668A1 (en) 2011-07-21
HK1170943A1 (en) 2013-03-15
JP2013515055A (ja) 2013-05-02
AU2010341650B2 (en) 2014-03-27
WO2011087671A1 (en) 2011-07-21
DOP2012000175A (es) 2012-08-31
MA33826B1 (fr) 2012-12-03
GT201200205A (es) 2014-04-08
US8415296B2 (en) 2013-04-09
CN102665752A (zh) 2012-09-12
KR101399692B1 (ko) 2014-05-27
MX2012007449A (es) 2012-11-23
NZ600732A (en) 2014-06-27
EA201290557A1 (ru) 2012-12-28
UA106399C2 (ru) 2014-08-26
TWI451873B (zh) 2014-09-11
CA2784668C (en) 2015-05-05
TW201143792A (en) 2011-12-16
ES2512141T3 (es) 2014-10-23
TN2012000303A1 (en) 2013-12-12
BR112012017054A2 (pt) 2016-11-22
AU2010341650A1 (en) 2012-06-07
KR20120096023A (ko) 2012-08-29
SG181872A1 (en) 2012-07-30

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