CO6410292A2 - 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3 - Google Patents

2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3

Info

Publication number
CO6410292A2
CO6410292A2 CO11107978A CO11107978A CO6410292A2 CO 6410292 A2 CO6410292 A2 CO 6410292A2 CO 11107978 A CO11107978 A CO 11107978A CO 11107978 A CO11107978 A CO 11107978A CO 6410292 A2 CO6410292 A2 CO 6410292A2
Authority
CO
Colombia
Prior art keywords
kcnq2
mercaptoquinolin
substituted
compounds
carboxamides
Prior art date
Application number
CO11107978A
Other languages
English (en)
Inventor
Sven Kuhnert
Gregor Bahrenberg
Wolfgang Schroder
Achim Kless
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40671387&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6410292(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of CO6410292A2 publication Critical patent/CO6410292A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un objetivo de la invención consiste en disponer de nuevos compuestos que presentaran ventajas frente a los compuestos existentes en el mercado para el tratamiento del dolor, especialmente del dolor neuropático. Los compuestos debían ser adecuados especialmente como principios activos farmacológicos en medicamentos, de preferencia en medicamentos para tratar alteraciones o enfermedades, que, al menos en parte, se transmiten a través de los canales de K+ KCNQ2/3. Inesperadamente, se descubrió que las 2-mercaptoquinolin-3-carboxamidas sustituidas de la fórmula general de la presente solicitud son adecuadas para el tratamiento del dolor. Asimismo, se descubrió que las 2-mercaptoquinolin-3-carboxamidas sustituidas de la fórmula general de la presente solicitud también presentan una afinidad sobresaliente con el canal de K+ KCNQ2/3 y, por lo tanto, son adecuadas para tratar alteraciones o enfermedades que, al menos en parte, se transmiten a través de los canales de K+ KCNQ2/3. De esta manera, las 2-mercaptoquinolin-3-carboxamidas sustituidas actúan como moduladores, es decir, agonistas o antagonistas, del canal de K+ KCNQ2/3, el procedimiento para producirlas, a los medicamentos que contienen estos compuestos, así como el uso de estos compuestos para la elaboración de medicamentos.
CO11107978A 2009-03-12 2011-08-24 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3 CO6410292A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09003597 2009-03-12

Publications (1)

Publication Number Publication Date
CO6410292A2 true CO6410292A2 (es) 2012-03-30

Family

ID=40671387

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11107978A CO6410292A2 (es) 2009-03-12 2011-08-24 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3

Country Status (20)

Country Link
US (2) US20100234372A1 (es)
EP (1) EP2406229A1 (es)
JP (1) JP5727946B2 (es)
KR (1) KR20110132590A (es)
CN (1) CN102348692A (es)
AR (1) AR075824A1 (es)
AU (1) AU2010223513B2 (es)
BR (1) BRPI1008939A2 (es)
CA (1) CA2755004A1 (es)
CL (1) CL2011002209A1 (es)
CO (1) CO6410292A2 (es)
EC (1) ECSP11011348A (es)
IL (1) IL214945A0 (es)
MX (1) MX2011009369A (es)
NZ (1) NZ595625A (es)
PE (1) PE20120790A1 (es)
RU (1) RU2011141188A (es)
TW (1) TWI461197B (es)
WO (1) WO2010102811A1 (es)
ZA (1) ZA201107444B (es)

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Also Published As

Publication number Publication date
AR075824A1 (es) 2011-04-27
RU2011141188A (ru) 2013-04-20
PE20120790A1 (es) 2012-07-08
CL2011002209A1 (es) 2012-02-10
EP2406229A1 (de) 2012-01-18
TWI461197B (zh) 2014-11-21
AU2010223513B2 (en) 2014-12-04
US8399673B2 (en) 2013-03-19
ECSP11011348A (es) 2011-10-31
AU2010223513A1 (en) 2011-11-03
US20120252841A1 (en) 2012-10-04
NZ595625A (en) 2012-10-26
MX2011009369A (es) 2011-09-27
CA2755004A1 (en) 2010-09-16
CN102348692A (zh) 2012-02-08
US20100234372A1 (en) 2010-09-16
ZA201107444B (en) 2012-06-27
TW201034670A (en) 2010-10-01
KR20110132590A (ko) 2011-12-08
IL214945A0 (en) 2011-11-30
BRPI1008939A2 (pt) 2016-03-15
WO2010102811A1 (de) 2010-09-16
JP5727946B2 (ja) 2015-06-03
JP2012520249A (ja) 2012-09-06

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