CO6351726A2 - Compuestos pirazolicos 436 - Google Patents

Compuestos pirazolicos 436

Info

Publication number
CO6351726A2
CO6351726A2 CO11005446A CO11005446A CO6351726A2 CO 6351726 A2 CO6351726 A2 CO 6351726A2 CO 11005446 A CO11005446 A CO 11005446A CO 11005446 A CO11005446 A CO 11005446A CO 6351726 A2 CO6351726 A2 CO 6351726A2
Authority
CO
Colombia
Prior art keywords
compounds
pirazolic
dimethoxyphenethyl
pyrazol
benzamide
Prior art date
Application number
CO11005446A
Other languages
English (en)
Inventor
David Buttar
Maria Elena Theoclitou
Andrew Peter Thomas
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40935715&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6351726(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO6351726A2 publication Critical patent/CO6351726A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan nuevos compuestos isómeros de N-(3-(3,5-dimetoxifenetil)-1H-pirazol-5-il)-4-(3, 4-dimetil piperazin -1-il) benzamida, de fórmula (la) o (Ib):aceptables de estos, procesos para su preparación, o sales farmacéuticamente composiciones farmacéuticas que los contienen y su uso en terapia.
CO11005446A 2008-06-19 2011-01-19 Compuestos pirazolicos 436 CO6351726A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7388308P 2008-06-19 2008-06-19

Publications (1)

Publication Number Publication Date
CO6351726A2 true CO6351726A2 (es) 2011-12-20

Family

ID=40935715

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11005446A CO6351726A2 (es) 2008-06-19 2011-01-19 Compuestos pirazolicos 436

Country Status (23)

Country Link
US (1) US20090318468A1 (es)
EP (1) EP2328872A1 (es)
JP (1) JP2011524888A (es)
KR (1) KR20110020904A (es)
CN (1) CN102123989A (es)
AR (1) AR072261A1 (es)
AU (1) AU2009261683A1 (es)
BR (1) BRPI0914233A2 (es)
CA (1) CA2728063A1 (es)
CL (1) CL2010001470A1 (es)
CO (1) CO6351726A2 (es)
CR (1) CR11857A (es)
DO (1) DOP2010000387A (es)
EA (1) EA201100030A1 (es)
EC (1) ECSP10010693A (es)
IL (1) IL210082A0 (es)
MX (1) MX2010014234A (es)
PE (1) PE20110062A1 (es)
SV (1) SV2010003767A (es)
TW (1) TW201002693A (es)
UY (1) UY31918A (es)
WO (1) WO2009153592A1 (es)
ZA (1) ZA201100471B (es)

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US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
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US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
AU2018317153B2 (en) 2017-08-15 2021-12-23 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. FGFR inhibitor and medical application thereof
DK3769765T3 (da) 2018-03-19 2024-05-13 Taiho Pharmaceutical Co Ltd Farmaceutisk sammensætning indeholdende natriumalkylsulfat
MX2020008610A (es) 2018-03-28 2020-09-21 Eisai R&D Man Co Ltd Agente terapeutico para carcinoma hepatocelular.
CN110317173B (zh) * 2018-03-30 2022-10-11 上海奕拓医药科技有限责任公司 用作fgfr不可逆抑制剂的酰胺基吡唑类化合物
JP2021523118A (ja) 2018-05-04 2021-09-02 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｆｇｆｒ阻害剤の塩
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
AU2020366006A1 (en) 2019-10-14 2022-04-21 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
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Also Published As

Publication number Publication date
UY31918A (es) 2010-01-29
DOP2010000387A (es) 2012-09-30
KR20110020904A (ko) 2011-03-03
MX2010014234A (es) 2011-03-25
CA2728063A1 (en) 2009-12-23
CN102123989A (zh) 2011-07-13
WO2009153592A1 (en) 2009-12-23
EP2328872A1 (en) 2011-06-08
CR11857A (es) 2011-02-25
SV2010003767A (es) 2011-05-20
TW201002693A (en) 2010-01-16
AR072261A1 (es) 2010-08-18
EA201100030A1 (ru) 2011-08-30
JP2011524888A (ja) 2011-09-08
CL2010001470A1 (es) 2011-05-06
IL210082A0 (en) 2011-02-28
BRPI0914233A2 (pt) 2015-11-03
AU2009261683A1 (en) 2009-12-23
ZA201100471B (en) 2012-06-27
ECSP10010693A (es) 2011-01-31
US20090318468A1 (en) 2009-12-24
PE20110062A1 (es) 2011-03-09

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