CO6331309A2 - Derivados 6-heterociclico-imidazo[1,2-alfa]piridina-2-carboxamidas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados 6-heterociclico-imidazo[1,2-alfa]piridina-2-carboxamidas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6331309A2 CO6331309A2 CO10080887A CO10080887A CO6331309A2 CO 6331309 A2 CO6331309 A2 CO 6331309A2 CO 10080887 A CO10080887 A CO 10080887A CO 10080887 A CO10080887 A CO 10080887A CO 6331309 A2 CO6331309 A2 CO 6331309A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- alkoxy
- halogen
- alkyl group
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 229910003827 NRaRb Inorganic materials 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Compuestos de formula (I)en la que:X representa un grupo fenilo sustituido opcionalmente con uno o varios grupos elegidos independientemente los unos de los otros entre los átomos o grupos siguientes:halógeno, alcoxi(C1-C6), alquilo(C1-C6), NRaRb, ciano, alcoxi(C1-C6)carbonilo, estando los grupos alquilo(C1-C6) y alcoxi(C1-C6) sustituidos opcionalmente con uno 10 o varios átomos de halógeno;R1, representa un átomo de hidrógeno, un halógeno, un grupo alcoxi(C1-C6), un grupo alquilo(C1-C6), un grupo NRaRb; pudiendo estar los grupos alquilo y alcoxi sustituidos opcionalmente con uno o varios halógeno, hidroxi, amino o grupo alcoxi(C1-C6);R2 representa un grupo heterocíclico aromático, insaturado, parcialmente saturado o totalmente saturado, sustituido opcionalmente con uno o varios grupos elegidos independientemente los unos de los otros entre los átomos o grupos siguientes:hidroxi, alcoxi(C1-C6), halógeno, ciano, NRaRb, -CO-R5, -CO-NR6R7, -CO-O-R8, -NR9-CO-R10 cicloalquilo(C3-C7)alquilo(C1-C6), cicloalquilo(C3-C7)alcoxi C1-C6), un grupo alquilo(C1-C6), sustituido opcionalmente con uno o varios hidroxi o NRaRb, un grupo óxido;R3; representa un átomo de hidrógeno, u11 grupo alquilo(C1-C6), un grupo alcoxi(C1-C6) o un átomo de halógeno; R4 representa un átomo de hidrógeno, un grupo alquilo(C1-C4), un grupo alcoxi(C1-C4) o un átomo de flúor; R5 representa un átomo de hidrógeno, un grupo fenilo o un grupo alquilo(C1-C6);R6 y R7, idénticos o diferentes, representan un átomo de hidrógeno o un grupo alquilo(C1-C6)o forman con el átomo de nitrógeno u11 ciclo de 4 a 7 eslabones que incluye opcionalmente otro heteroátomo elegido entre N, O o S;R8 representa un grupo alquilo(C1-C6);R9 y R10, idénticos o diferentes, representan un átomo de hidrógeno o un grupo alquilo(C1-C6);Ra y Rb son independientemente el uno del otro, hidrógeno alquilo(C1-C6) o forman con el átomo de nitrógeno al que están unidos un ciclo de 4 a 7 eslabones, que incluye opcionalmente otro heteroátomo elegido entre N, O o S;con la excepción de N-(4-bromofenil)-6-(1-metil-2- piperidinil)imidazo[1,2-a]piridina-2-carboxamida;en el estado de base o de sal de adición a un ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800005A FR2925903B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6331309A2 true CO6331309A2 (es) | 2011-10-20 |
Family
ID=39745373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10080887A CO6331309A2 (es) | 2008-01-02 | 2010-07-02 | Derivados 6-heterociclico-imidazo[1,2-alfa]piridina-2-carboxamidas su preparacion y su aplicacion en terapeutica |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8314109B2 (es) |
| EP (1) | EP2225240B1 (es) |
| JP (1) | JP5258899B2 (es) |
| KR (1) | KR101600635B1 (es) |
| CN (1) | CN101959884B (es) |
| AR (1) | AR070074A1 (es) |
| AU (1) | AU2008351928B2 (es) |
| BR (1) | BRPI0821458A2 (es) |
| CA (1) | CA2710947C (es) |
| CL (1) | CL2008003928A1 (es) |
| CO (1) | CO6331309A2 (es) |
| EA (1) | EA019122B1 (es) |
| FR (1) | FR2925903B1 (es) |
| HK (1) | HK1148016A1 (es) |
| IL (1) | IL206669A (es) |
| MA (1) | MA32527B1 (es) |
| ME (1) | ME01157B (es) |
| MX (1) | MX2010007353A (es) |
| MY (1) | MY155468A (es) |
| NZ (1) | NZ586474A (es) |
| SG (1) | SG187408A1 (es) |
| TW (1) | TWI432432B (es) |
| UY (1) | UY31589A1 (es) |
| WO (1) | WO2009106750A2 (es) |
| ZA (1) | ZA201004644B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| CA2852615A1 (en) * | 2011-10-21 | 2013-04-25 | Torrent Pharmaceuticals Limited | Novel substituted imidazopyrimidines as gpbar1 receptor modulators |
| KR101716993B1 (ko) | 2012-12-25 | 2017-03-15 | 닛뽕소다 가부시키가이샤 | 할로겐화 아닐린 및 그 제조 방법 |
| CN108295074B (zh) * | 2018-02-01 | 2020-08-28 | 华中农业大学 | 一种噻二唑并三嗪类化合物在制备单胺氧化酶抑制剂中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2638161B1 (fr) * | 1988-10-24 | 1991-01-11 | Centre Nat Rech Scient | Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| IE904346A1 (en) * | 1989-12-04 | 1991-06-05 | Searle & Co | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY |
| AU2003269354B2 (en) * | 2002-09-24 | 2008-03-06 | Neuro Therapeutics Ab | Methods for promoting dopaminergic neuronal development by using NG4A-subfamily and Wnt-ligands |
| EP1567527A1 (en) * | 2002-11-27 | 2005-08-31 | Eli Lilly And Company | Condensed pyrazolo derivatives |
| WO2004103991A1 (fr) * | 2003-05-20 | 2004-12-02 | 'chemical Diversity Research Institute', Ltd. | Piperidines 2-substituees, bibliotheque focalisee et composition pharmaceutique |
| DE102005019181A1 (de) * | 2005-04-25 | 2006-10-26 | Novartis Ag | Peptid-Deformylase (PDF) Inhibitoren 1 |
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2903106B1 (fr) * | 2006-07-03 | 2010-07-30 | Sanofi Aventis | Utilisations de 2-benzoyl-imidazopyridines en therapeutique |
-
2008
- 2008-01-02 FR FR0800005A patent/FR2925903B1/fr not_active Expired - Fee Related
- 2008-12-30 UY UY31589A patent/UY31589A1/es not_active Application Discontinuation
- 2008-12-30 AR ARP080105779A patent/AR070074A1/es unknown
- 2008-12-30 CL CL2008003928A patent/CL2008003928A1/es unknown
- 2008-12-31 WO PCT/FR2008/001836 patent/WO2009106750A2/fr active Application Filing
- 2008-12-31 ME MEP-2010-103A patent/ME01157B/me unknown
- 2008-12-31 EP EP08872775.5A patent/EP2225240B1/fr active Active
- 2008-12-31 CN CN2008801277669A patent/CN101959884B/zh not_active Expired - Fee Related
- 2008-12-31 NZ NZ586474A patent/NZ586474A/en not_active IP Right Cessation
- 2008-12-31 EA EA201070814A patent/EA019122B1/ru not_active IP Right Cessation
- 2008-12-31 TW TW097151708A patent/TWI432432B/zh not_active IP Right Cessation
- 2008-12-31 JP JP2010541085A patent/JP5258899B2/ja not_active Expired - Fee Related
- 2008-12-31 MX MX2010007353A patent/MX2010007353A/es active IP Right Grant
- 2008-12-31 KR KR1020107017143A patent/KR101600635B1/ko not_active IP Right Cessation
- 2008-12-31 MY MYPI2010003073A patent/MY155468A/en unknown
- 2008-12-31 BR BRPI0821458-1A patent/BRPI0821458A2/pt not_active IP Right Cessation
- 2008-12-31 SG SG2012096269A patent/SG187408A1/en unknown
- 2008-12-31 CA CA2710947A patent/CA2710947C/fr not_active Expired - Fee Related
- 2008-12-31 AU AU2008351928A patent/AU2008351928B2/en not_active Ceased
-
2010
- 2010-06-28 IL IL206669A patent/IL206669A/en not_active IP Right Cessation
- 2010-07-01 ZA ZA2010/04644A patent/ZA201004644B/en unknown
- 2010-07-01 US US12/828,374 patent/US8314109B2/en not_active Expired - Fee Related
- 2010-07-02 CO CO10080887A patent/CO6331309A2/es active IP Right Grant
- 2010-07-27 MA MA33051A patent/MA32527B1/fr unknown
-
2011
- 2011-03-07 HK HK11102219.8A patent/HK1148016A1/xx not_active IP Right Cessation
-
2012
- 2012-10-10 US US13/648,731 patent/US8691990B2/en not_active Expired - Fee Related
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| FG | Application granted |