CO6260075A2 - Derivados de 2, 4- diamino pirimidina como inhibidores de eph b4 o eph a2 utiles en el tratamiento de cancer - Google Patents
Derivados de 2, 4- diamino pirimidina como inhibidores de eph b4 o eph a2 utiles en el tratamiento de cancerInfo
- Publication number
- CO6260075A2 CO6260075A2 CO10017544A CO10017544A CO6260075A2 CO 6260075 A2 CO6260075 A2 CO 6260075A2 CO 10017544 A CO10017544 A CO 10017544A CO 10017544 A CO10017544 A CO 10017544A CO 6260075 A2 CO6260075 A2 CO 6260075A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- amino
- hydrogen
- alkanoyl
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto de Fórmula (I):en la que uno de A1, A2 o A3 es N, y los otros se seleccionan independientemente de CH o N;R1 es hidrógeno o un grupo alquilo (C1-4) que está opcionalmente sustituido con uno o más grupos sustituyentes seleccionados de -OR5 (en el que R5 se selecciona de hidrógeno o alquilo (C1-2), ciano, halo, o -NR6R7 (en el que R6 y R7 se seleccionan independientemente de hidrógeno, alquilo (C1-2) o alcanoilo (C1-2);el anillo B es un anillo carbocíclico o heterocíclico de 5 ó 6 miembros condensado que está opcionalmente sustituido en un átomo de carbono con uno o más grupos halo o grupos alquilo C1-6, y en el que cualesquiera átomos de nitrógeno en el anillo están opcionalmente sustituidos con un alquilo C1-6 o alquil C1-6-carbonilo;n es 0, 1, 2 ó 3,y cada grupo R2 se selecciona independientemente de halógeno, trifluorometilo, ciano, nitro o un grupo de sub-Fórmula (i):-X1-R11 (i)en la que X1 se selecciona de un enlace directo u O, S, SO, SO2, OSO2, NR13, CO, CH(OR13), CONR13, N(R13)CO, SO2N(R13), N(R13)SO2, C(R13)2O, C(R13)2S, C(R13)2N(R13) y N(R13)C(R13)2, en los que R13 es hidrógeno o alquilo C1-6, yR11 se selecciona de hidrógeno, alquilo C1-6, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, arilo o heterociclilo, alquil C1-6-cicloalquilo C3-8, alquil C1-6-arilo o alquil C1-6-heterociclilo, cualquiera de los cuales puede estar opcionalmente sustituido con uno o más grupos seleccionados de halógeno, trifluorometilo, ciano, nitro, hidroxi, amino, carboxi, carbamoilo, alcoxi C1-6, alquenil C2-6-oxi, alquinil C2-6-oxi, alquil C1-6-tio, alquil C1-6-sulfinilo, alquil C1-6-sulfonilo, alquil C1-6-amino, di-(alquil C1-6)amino, alcoxi C1-6-carbonilo, N-alquil C1-6-carbamoilo, N,N-di-(alquil C1-6)carbamoilo, alcanoilo C2-6, alcanoil C2-6-oxi, alcanoil C2-6-amino, N-alquil C1-6-alcanoil C2-6-amino, alquenoil C3-6-amino, N-alquil C1-6-alquenoil C3-6-amino, alquinoil C3-6-amino, N-alquil C1-6-alquinoil C3-6-amino, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07301236 | 2007-07-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6260075A2 true CO6260075A2 (es) | 2011-03-22 |
Family
ID=40260140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10017544A CO6260075A2 (es) | 2007-07-16 | 2010-02-16 | Derivados de 2, 4- diamino pirimidina como inhibidores de eph b4 o eph a2 utiles en el tratamiento de cancer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7718653B2 (es) |
| EP (1) | EP2183242A2 (es) |
| JP (1) | JP2010533700A (es) |
| KR (1) | KR20100042272A (es) |
| CN (1) | CN101796046A (es) |
| AU (1) | AU2008277446A1 (es) |
| BR (1) | BRPI0814821A2 (es) |
| CA (1) | CA2693880A1 (es) |
| CO (1) | CO6260075A2 (es) |
| CR (1) | CR11220A (es) |
| DO (1) | DOP2010000022A (es) |
| EA (1) | EA201000101A1 (es) |
| EC (1) | ECSP109958A (es) |
| MX (1) | MX2010000658A (es) |
| NI (1) | NI201000011A (es) |
| SV (1) | SV2010003459A (es) |
| WO (1) | WO2009010789A2 (es) |
| ZA (1) | ZA201000107B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012029647A2 (pt) | 2010-05-21 | 2016-08-02 | Chemilia Ab | novos derivados de pirimidinas |
| RU2013147417A (ru) | 2011-03-24 | 2015-04-27 | Кемилиа Аб | Новые производные пиримидина |
| CN111499580A (zh) | 2011-04-22 | 2020-08-07 | 西格诺药品有限公司 | 取代的二氨基甲酰胺和二氨基甲腈嘧啶，其组合物，和用其治疗的方法 |
| EP2705521B1 (de) | 2011-05-03 | 2021-06-23 | Phoenix Contact GmbH & Co. KG | Anordnung und verfahren zur kontaklosen energieübertragung mit einer kopplungsminimierten matrix aus planaren sendespulen |
| CN103222842B (zh) | 2013-04-18 | 2015-09-09 | 安翰光电技术（武汉）有限公司 | 一种控制胶囊内窥镜在人体消化道运动的装置及方法 |
| NZ715903A (en) | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
| EA033530B1 (ru) | 2014-12-16 | 2019-10-31 | Signal Pharm Llc | Композиции 2-(трет-бутиламино)-4-((1r,3r,4r)-3-гидрокси-4-метилциклогексиламино)пиримидин-5-карбоксамида |
| WO2016100308A1 (en) | 2014-12-16 | 2016-06-23 | Signal Pharmaceuticals, Llc | Methods for measurement of inhibition of c-jun n-terminal kinase in skin |
| WO2016123291A1 (en) | 2015-01-29 | 2016-08-04 | Signal Pharmaceuticals, Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| JP6805232B2 (ja) | 2015-07-24 | 2020-12-23 | セルジーン コーポレイション | （１ｒ，２ｒ，５ｒ）−５−アミノ−２−メチルシクロヘキサノール塩酸塩の合成方法及びそれに有用な中間体 |
| CN106543089A (zh) * | 2016-11-04 | 2017-03-29 | 山东铂源药业有限公司 | 一种达沙替尼中间体的合成方法 |
| WO2021239133A1 (zh) * | 2020-05-29 | 2021-12-02 | 南京正大天晴制药有限公司 | 作为axl抑制剂的嘧啶类化合物 |
| CN116178433A (zh) * | 2021-11-26 | 2023-05-30 | 南京正大天晴制药有限公司 | Axl激酶抑制剂的盐及其制备方法和用途 |
| CN116178434A (zh) * | 2021-11-26 | 2023-05-30 | 南京正大天晴制药有限公司 | Axl激酶抑制剂的单对甲苯磺酸盐及其晶型 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2400447C (en) * | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
| ES2286408T3 (es) | 2002-03-05 | 2007-12-01 | Astrazeneca Ab | Sales de alquilamonio de omeprazol e esomeprazol. |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| SI1660458T1 (sl) * | 2003-08-15 | 2012-05-31 | Novartis Ag | pirimidindiamini uporabni pri zdravljenju neoplastičnih bolezni vnetnih motenj in motenj imunskega sistema |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| CN101155799A (zh) | 2005-03-16 | 2008-04-02 | 塔格根公司 | 嘧啶化合物和使用方法 |
| WO2006129100A1 (en) * | 2005-06-03 | 2006-12-07 | Glaxo Group Limited | Novel compounds |
| WO2007028445A1 (en) * | 2005-07-15 | 2007-03-15 | Glaxo Group Limited | 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives |
| TW200740805A (en) | 2005-07-15 | 2007-11-01 | Glaxo Group Ltd | Novel compounds |
| US20090149467A1 (en) | 2005-09-15 | 2009-06-11 | Merck & Co., Inc. | Tyrosine Kinase Inhibitors |
| NZ592990A (en) * | 2005-11-01 | 2013-01-25 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
| TW200736232A (en) | 2006-01-26 | 2007-10-01 | Astrazeneca Ab | Pyrimidine derivatives |
| WO2007085540A1 (en) | 2006-01-27 | 2007-08-02 | Glaxo Group Limited | 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives |
| TW200840581A (en) | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
| WO2008118822A1 (en) * | 2007-03-23 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| RU2009143753A (ru) | 2007-04-27 | 2011-06-10 | Астразенека Аб (Se) | Производные n'-(фенил)-n-(морфолин-4-ил-пиридин-2-ил)-пиримидин-2, 4-идиамина в качестве ингибиторов ернв4 киназы для лечения пролиферативных состояний |
-
2008
- 2008-07-14 KR KR1020107002514A patent/KR20100042272A/ko not_active Application Discontinuation
- 2008-07-14 EP EP08776197A patent/EP2183242A2/en not_active Withdrawn
- 2008-07-14 EA EA201000101A patent/EA201000101A1/ru unknown
- 2008-07-14 JP JP2010516595A patent/JP2010533700A/ja active Pending
- 2008-07-14 AU AU2008277446A patent/AU2008277446A1/en not_active Abandoned
- 2008-07-14 CN CN200880105690A patent/CN101796046A/zh active Pending
- 2008-07-14 WO PCT/GB2008/050562 patent/WO2009010789A2/en active Application Filing
- 2008-07-14 CA CA2693880A patent/CA2693880A1/en not_active Abandoned
- 2008-07-14 MX MX2010000658A patent/MX2010000658A/es active IP Right Grant
- 2008-07-14 BR BRPI0814821-0A2A patent/BRPI0814821A2/pt not_active IP Right Cessation
- 2008-07-16 US US12/174,339 patent/US7718653B2/en not_active Expired - Fee Related
-
2010
- 2010-01-06 ZA ZA201000107A patent/ZA201000107B/xx unknown
- 2010-01-15 NI NI201000011A patent/NI201000011A/es unknown
- 2010-01-15 CR CR11220A patent/CR11220A/es not_active Application Discontinuation
- 2010-01-15 DO DO2010000022A patent/DOP2010000022A/es unknown
- 2010-01-15 SV SV2010003459A patent/SV2010003459A/es not_active Application Discontinuation
- 2010-02-11 EC EC2010009958A patent/ECSP109958A/es unknown
- 2010-02-16 CO CO10017544A patent/CO6260075A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010533700A (ja) | 2010-10-28 |
| ECSP109958A (es) | 2010-03-31 |
| ZA201000107B (en) | 2010-09-29 |
| MX2010000658A (es) | 2010-03-26 |
| CA2693880A1 (en) | 2009-01-22 |
| NI201000011A (es) | 2010-12-07 |
| CR11220A (es) | 2010-05-20 |
| EP2183242A2 (en) | 2010-05-12 |
| WO2009010789A2 (en) | 2009-01-22 |
| DOP2010000022A (es) | 2010-02-15 |
| AU2008277446A1 (en) | 2009-01-22 |
| US20090023719A1 (en) | 2009-01-22 |
| EA201000101A1 (ru) | 2010-08-30 |
| CN101796046A (zh) | 2010-08-04 |
| US7718653B2 (en) | 2010-05-18 |
| BRPI0814821A2 (pt) | 2015-02-03 |
| WO2009010789A3 (en) | 2009-05-07 |
| SV2010003459A (es) | 2010-04-30 |
| KR20100042272A (ko) | 2010-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |