CO6230991A2 - Derivados de 3,4-dihidro-1,4-benzoxazina, 3,4 -dihidro-1 4-benzotiazina y 1,2,3,4-tetrahidro-quinoxalina como agonistas de los adrenoreceptores alpha2c - Google Patents

Derivados de 3,4-dihidro-1,4-benzoxazina, 3,4 -dihidro-1 4-benzotiazina y 1,2,3,4-tetrahidro-quinoxalina como agonistas de los adrenoreceptores alpha2c

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Publication number
CO6230991A2
CO6230991A2 CO09084452A CO09084452A CO6230991A2 CO 6230991 A2 CO6230991 A2 CO 6230991A2 CO 09084452 A CO09084452 A CO 09084452A CO 09084452 A CO09084452 A CO 09084452A CO 6230991 A2 CO6230991 A2 CO 6230991A2
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Colombia
Prior art keywords
dihidro
alkyl
group
halo
alkoxy
Prior art date
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CO09084452A
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English (en)
Inventor
Kevin D Mccormick
Christopher W Boyce
Neng-Yang Shih
Robert G Aslanian
Salem Fevrier
Pietro Mangiaracina
Lera Ruiz Manuel De
Younong Yu
Junying Zheng
Chia-Yu Huang
Bo Liang
Rong-Quiang Liu
Ruiyan Liu
Lisa Guise-Zawacki
Original Assignee
Schering Corp
Pharmacopeia Llc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39512854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6230991(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp, Pharmacopeia Llc filed Critical Schering Corp
Publication of CO6230991A2 publication Critical patent/CO6230991A2/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
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    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Un compuesto que tiene la estructura general que se muestra en la Fórmula I:o una sal, éster, solvato o prodroga farmacéuticamente aceptable de dicho compuesto donde: A es un anillo heterocíclico de 5 miembros que contiene 1-3 heteroátomos, y está opcionalmente sustituido con por lo menos un R5 y/o 1 o 2 grupos (=O) (carbonilo); X es -O-, -S(O)p-, o N(R6)-;J1, J2, J3, y J4 son independientemente -N-, -N(O)- o -C(R2)-, con la condición de que 0-3 de J1, J2, J3 y J4 sean -N-; R2 está independientemente seleccionado del grupo que consiste en H, -OH, halo, -CN, -NO2, -S(O)pR7, -NR7R7', -[C(Ra)(Rb)]qYR7', -[C(Ra)(Rb)]qN(R7)YR7´, C(Ra)(Rb)]qOYR7', -[C(Ra)Rb)]qON=CR7R7´, -P(=O)(OR7)(OR7´), -P(=O)NR7R7', y -P(=O)R82, y grupos alquilo, alcoxi, alquenilo, alqueniloxi, alquinilo, cicloalquilo, cicloalcoxi, arilo, ariloxi, arilalquilo, heteroarilo, heteroarilalquilo, heterociclilo, y heterociclilalquilo, sustituidos opcionalmente con por lo menos un R5;Y está seleccionado del grupo que consiste en un enlace, -C(=O)-, -C(=O)NR7-, -C(=O)O-, -C(=NR7)-, -C(=O)[C(Ra)(Rb)]n´, -O-C(=O)-, -C(=O)N(Rc)-O-, -C(=NOR7), -C(=NR7)NR7-, -C(=NR7)N(Rc)O, -S(O)p-, -SO2NR7-, y -C(S)NR7-; donde Ra y Rb están independientemente seleccionados del grupo que consiste en H, alquilo, alcoxi, y halo, Rc es H o alquilo; R3 está independientemente seleccionado del grupo que consiste en H, halo, y (=O), y grupos alquilo, alcoxi, alquenilo, alqueniloxi, alquinilo, cicloalquilo, cicloalcoxi, arilo, ariloxi, arilalquilo, heteroarilo, heteroarilalquilo, heterociclilo, y heterociclilalquilo, opcionalmente sustituidos con por lo menos un R5, con la condición de que cuando n es 3 o 4, no más de 2 de los grupos R3 pueden ser(=O); R4 está independientemente seleccionado del grupo que consiste en H, -CN, y halo, y grupos alquilo, alcoxi, alquenilo, alqueniloxi, alquinilo, cicloalquilo, cicloalcoxi, arilo, ariloxi, arilalquilo, heteroarilo, ...
CO09084452A 2007-02-13 2009-08-12 Derivados de 3,4-dihidro-1,4-benzoxazina, 3,4 -dihidro-1 4-benzotiazina y 1,2,3,4-tetrahidro-quinoxalina como agonistas de los adrenoreceptores alpha2c CO6230991A2 (es)

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US11/705,673 US7700592B2 (en) 2005-08-25 2007-02-13 α2C adrenoreceptor agonists

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US (1) US7700592B2 (es)
EP (1) EP2194986A1 (es)
JP (1) JP2010518162A (es)
KR (1) KR20090111345A (es)
CN (1) CN102264369A (es)
AR (1) AR065310A1 (es)
AU (1) AU2008216804A1 (es)
BR (1) BRPI0807911A2 (es)
CA (1) CA2677678A1 (es)
CL (1) CL2008000438A1 (es)
CO (1) CO6230991A2 (es)
EC (1) ECSP099574A (es)
IL (1) IL200337A0 (es)
MX (1) MX2009008773A (es)
PE (1) PE20081782A1 (es)
RU (1) RU2009134061A (es)
TW (1) TW200836746A (es)
WO (1) WO2008100463A1 (es)
ZA (1) ZA200906127B (es)

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IL200337A0 (en) 2010-04-29
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MX2009008773A (es) 2010-01-29
AR065310A1 (es) 2009-05-27
KR20090111345A (ko) 2009-10-26
PE20081782A1 (es) 2008-12-18
US7700592B2 (en) 2010-04-20
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