CO6230991A2 - Derivados de 3,4-dihidro-1,4-benzoxazina, 3,4 -dihidro-1 4-benzotiazina y 1,2,3,4-tetrahidro-quinoxalina como agonistas de los adrenoreceptores alpha2c - Google Patents

Derivados de 3,4-dihidro-1,4-benzoxazina, 3,4 -dihidro-1 4-benzotiazina y 1,2,3,4-tetrahidro-quinoxalina como agonistas de los adrenoreceptores alpha2c

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Publication number
CO6230991A2
CO6230991A2 CO09084452A CO09084452A CO6230991A2 CO 6230991 A2 CO6230991 A2 CO 6230991A2 CO 09084452 A CO09084452 A CO 09084452A CO 09084452 A CO09084452 A CO 09084452A CO 6230991 A2 CO6230991 A2 CO 6230991A2
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Prior art keywords
dihidro
alkyl
group
halo
alkoxy
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CO09084452A
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English (en)
Inventor
Kevin D Mccormick
Christopher W Boyce
Neng-Yang Shih
Robert G Aslanian
Salem Fevrier
Pietro Mangiaracina
Lera Ruiz Manuel De
Younong Yu
Junying Zheng
Chia-Yu Huang
Bo Liang
Rong-Quiang Liu
Ruiyan Liu
Lisa Guise-Zawacki
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Schering Corp
Pharmacopeia Llc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39512854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6230991(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp, Pharmacopeia Llc filed Critical Schering Corp
Publication of CO6230991A2 publication Critical patent/CO6230991A2/es

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Abstract

1.- Un compuesto que tiene la estructura general que se muestra en la Fórmula I:o una sal, éster, solvato o prodroga farmacéuticamente aceptable de dicho compuesto donde: A es un anillo heterocíclico de 5 miembros que contiene 1-3 heteroátomos, y está opcionalmente sustituido con por lo menos un R5 y/o 1 o 2 grupos (=O) (carbonilo); X es -O-, -S(O)p-, o N(R6)-;J1, J2, J3, y J4 son independientemente -N-, -N(O)- o -C(R2)-, con la condición de que 0-3 de J1, J2, J3 y J4 sean -N-; R2 está independientemente seleccionado del grupo que consiste en H, -OH, halo, -CN, -NO2, -S(O)pR7, -NR7R7', -[C(Ra)(Rb)]qYR7', -[C(Ra)(Rb)]qN(R7)YR7´, C(Ra)(Rb)]qOYR7', -[C(Ra)Rb)]qON=CR7R7´, -P(=O)(OR7)(OR7´), -P(=O)NR7R7', y -P(=O)R82, y grupos alquilo, alcoxi, alquenilo, alqueniloxi, alquinilo, cicloalquilo, cicloalcoxi, arilo, ariloxi, arilalquilo, heteroarilo, heteroarilalquilo, heterociclilo, y heterociclilalquilo, sustituidos opcionalmente con por lo menos un R5;Y está seleccionado del grupo que consiste en un enlace, -C(=O)-, -C(=O)NR7-, -C(=O)O-, -C(=NR7)-, -C(=O)[C(Ra)(Rb)]n´, -O-C(=O)-, -C(=O)N(Rc)-O-, -C(=NOR7), -C(=NR7)NR7-, -C(=NR7)N(Rc)O, -S(O)p-, -SO2NR7-, y -C(S)NR7-; donde Ra y Rb están independientemente seleccionados del grupo que consiste en H, alquilo, alcoxi, y halo, Rc es H o alquilo; R3 está independientemente seleccionado del grupo que consiste en H, halo, y (=O), y grupos alquilo, alcoxi, alquenilo, alqueniloxi, alquinilo, cicloalquilo, cicloalcoxi, arilo, ariloxi, arilalquilo, heteroarilo, heteroarilalquilo, heterociclilo, y heterociclilalquilo, opcionalmente sustituidos con por lo menos un R5, con la condición de que cuando n es 3 o 4, no más de 2 de los grupos R3 pueden ser(=O); R4 está independientemente seleccionado del grupo que consiste en H, -CN, y halo, y grupos alquilo, alcoxi, alquenilo, alqueniloxi, alquinilo, cicloalquilo, cicloalcoxi, arilo, ariloxi, arilalquilo, heteroarilo, ...
CO09084452A 2007-02-13 2009-08-12 Derivados de 3,4-dihidro-1,4-benzoxazina, 3,4 -dihidro-1 4-benzotiazina y 1,2,3,4-tetrahidro-quinoxalina como agonistas de los adrenoreceptores alpha2c CO6230991A2 (es)

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US11/705,673 US7700592B2 (en) 2005-08-25 2007-02-13 α2C adrenoreceptor agonists

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CO6230991A2 true CO6230991A2 (es) 2010-12-20

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US (1) US7700592B2 (es)
EP (1) EP2194986A1 (es)
JP (1) JP2010518162A (es)
KR (1) KR20090111345A (es)
CN (1) CN102264369A (es)
AR (1) AR065310A1 (es)
AU (1) AU2008216804A1 (es)
BR (1) BRPI0807911A2 (es)
CA (1) CA2677678A1 (es)
CL (1) CL2008000438A1 (es)
CO (1) CO6230991A2 (es)
EC (1) ECSP099574A (es)
IL (1) IL200337A0 (es)
MX (1) MX2009008773A (es)
PE (1) PE20081782A1 (es)
RU (1) RU2009134061A (es)
TW (1) TW200836746A (es)
WO (1) WO2008100463A1 (es)
ZA (1) ZA200906127B (es)

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IL200337A0 (en) 2010-04-29
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MX2009008773A (es) 2010-01-29
AR065310A1 (es) 2009-05-27
KR20090111345A (ko) 2009-10-26
PE20081782A1 (es) 2008-12-18
US7700592B2 (en) 2010-04-20
TW200836746A (en) 2008-09-16
EP2194986A1 (en) 2010-06-16
CL2008000438A1 (es) 2008-06-06
ZA200906127B (en) 2010-06-30
CA2677678A1 (en) 2008-08-21
US20080039439A1 (en) 2008-02-14
AU2008216804A1 (en) 2008-08-21
CN102264369A (zh) 2011-11-30
BRPI0807911A2 (pt) 2014-06-17
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