CO6190525A2 - Fosfoindoles enantiomericamente puros como inhibidores de vih - Google Patents
Fosfoindoles enantiomericamente puros como inhibidores de vihInfo
- Publication number
- CO6190525A2 CO6190525A2 CO09033082A CO09033082A CO6190525A2 CO 6190525 A2 CO6190525 A2 CO 6190525A2 CO 09033082 A CO09033082 A CO 09033082A CO 09033082 A CO09033082 A CO 09033082A CO 6190525 A2 CO6190525 A2 CO 6190525A2
- Authority
- CO
- Colombia
- Prior art keywords
- carbon atoms
- hydrogen
- alkenyl
- alkyl
- nrr
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 11
- 239000001257 hydrogen Substances 0.000 abstract 11
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 125000005518 carboxamido group Chemical group 0.000 abstract 2
- -1 hydrate Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1.- Un compuesto puro de la fórmula (A), o una sal, solvato, hidrato, o éster farmacéuticamente aceptable del mismo:en donde: X es hidrógeno; arilo o heterociclo; alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, o alquilo; Y es hidrógeno, -R, -O-R, -NH-R, o -NRR; Z es -OR, -NHR, -NRR, carboxamido, amido, carboxilo, carbonilo, o un residuo de aminoácido;R1 es hidrógeno, acilo, -S(O)n-R, carboxilo, carbonilo, o un residuo de aminoácido; cada R4', R5´, R6' y R7´ es independientemente hidrógeno, alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, arilo, heterociclo, halógeno, -CN, -CF3, -OR, -NHR, -NRR, o -NO2;n es 0, 1, ó 2; y cada R es independientemente hidrógeno, alquilo, alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, arilo, o heterociclo. 2.- El compuesto de la reivindicación 1, en donde X es arilo o heterociclo; alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, o alquilo; yY es -R, O-R, -NH-R, o -NRR. 3.- El compuesto de la reivindicación 1, en donde: cada R4' y R5´ es independientemente hidrógeno o halógeno R6´ y R7´ son hidrógeno; R1 es hidrógeno o -S(O)n-R; Y es hidrógeno, -R, ó -O-R;Z es carboxamido, amido, carboxilo, o carbonilo;n es 1 ó 2; ycada R es independientemente hidrógeno o alquilo. 4.- El compuesto de cualquiera de las reivindicaciones de 1 a 3 de acuerdo con la fórmula (C):en donde cada R2", R3", R4", R5" y R6" es independientemente hidrógeno, halógeno, alquilo sustituido o insustituido, o alquenilo de 2 a 6 átomos de carbono sustituido o insustituido.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84858406P | 2006-09-29 | 2006-09-29 | |
| US85798006P | 2006-11-09 | 2006-11-09 | |
| US90311507P | 2007-02-23 | 2007-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190525A2 true CO6190525A2 (es) | 2010-08-19 |
Family
ID=39145445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09033082A CO6190525A2 (es) | 2006-09-29 | 2009-03-31 | Fosfoindoles enantiomericamente puros como inhibidores de vih |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7960428B2 (es) |
| EP (1) | EP2078029B1 (es) |
| JP (1) | JP2010504978A (es) |
| KR (1) | KR20090077813A (es) |
| AU (1) | AU2007305447A1 (es) |
| BR (1) | BRPI0717511A2 (es) |
| CA (1) | CA2664396A1 (es) |
| CO (1) | CO6190525A2 (es) |
| CR (1) | CR10693A (es) |
| EA (1) | EA016267B1 (es) |
| ES (1) | ES2488922T3 (es) |
| HK (1) | HK1129679A1 (es) |
| IL (1) | IL197777A (es) |
| MA (1) | MA30806B1 (es) |
| MX (1) | MX2009003410A (es) |
| NO (1) | NO20091258L (es) |
| NZ (1) | NZ575831A (es) |
| TW (1) | TW200821287A (es) |
| WO (1) | WO2008042240A2 (es) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1799696B1 (en) * | 2004-09-17 | 2008-11-12 | IDENIX Pharmaceuticals, Inc. | Phosphoindoles as hiv inhibitors |
| CA2664396A1 (en) | 2006-09-29 | 2008-04-10 | Idenix Pharmaceuticals, Inc. | Enantiomerically pure phosphoindoles as hiv inhibitors |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| TW200946541A (en) * | 2008-03-27 | 2009-11-16 | Idenix Pharmaceuticals Inc | Solid forms of an anti-HIV phosphoindole compound |
| TW200944537A (en) * | 2008-04-03 | 2009-11-01 | Idenix Pharmaceuticals Inc | Formulations comprising a phosphoindole compound and one or more second active agents |
| CN102115452A (zh) * | 2009-12-30 | 2011-07-06 | 上海特化医药科技有限公司 | (e)-3-(3-取代-5-甲基苯基)丙烯腈及其制备方法 |
| ES2969969T3 (es) | 2010-01-27 | 2024-05-23 | Viiv Healthcare Co | Combinaciones de dolutegravir y lamivudina para el tratamiento de la infección por VIH |
| KR101301253B1 (ko) * | 2011-12-09 | 2013-08-28 | 한국원자력연구원 | 방사선을 이용한 크로메논 유도체의 제조방법 |
| WO2013142873A2 (en) | 2012-03-23 | 2013-09-26 | The Board Of Trustees Of The University Of Illinois | Complex and structurally diverse compounds |
| US9867819B2 (en) | 2013-11-05 | 2018-01-16 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects |
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- 2007-09-28 EA EA200900358A patent/EA016267B1/ru not_active IP Right Cessation
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- 2007-09-28 BR BRPI0717511-6A patent/BRPI0717511A2/pt not_active IP Right Cessation
- 2007-09-28 AU AU2007305447A patent/AU2007305447A1/en not_active Abandoned
- 2007-09-28 MX MX2009003410A patent/MX2009003410A/es active IP Right Grant
- 2007-09-28 WO PCT/US2007/020900 patent/WO2008042240A2/en active Application Filing
- 2007-09-28 EP EP07838974.9A patent/EP2078029B1/en active Active
- 2007-09-28 JP JP2009530421A patent/JP2010504978A/ja active Pending
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| IL197777A0 (en) | 2009-12-24 |
| EP2078029B1 (en) | 2014-05-14 |
| US8486991B2 (en) | 2013-07-16 |
| WO2008042240A3 (en) | 2008-06-05 |
| MX2009003410A (es) | 2009-07-17 |
| KR20090077813A (ko) | 2009-07-15 |
| MA30806B1 (fr) | 2009-10-01 |
| JP2010504978A (ja) | 2010-02-18 |
| US7960428B2 (en) | 2011-06-14 |
| WO2008042240A2 (en) | 2008-04-10 |
| TW200821287A (en) | 2008-05-16 |
| CR10693A (es) | 2009-06-25 |
| EP2078029A2 (en) | 2009-07-15 |
| AU2007305447A1 (en) | 2008-04-10 |
| HK1129679A1 (en) | 2009-12-04 |
| EA200900358A1 (ru) | 2009-10-30 |
| EA016267B1 (ru) | 2012-03-30 |
| BRPI0717511A2 (pt) | 2013-11-19 |
| NO20091258L (no) | 2009-06-22 |
| IL197777A (en) | 2013-08-29 |
| ES2488922T3 (es) | 2014-09-01 |
| US20080213217A1 (en) | 2008-09-04 |
| NZ575831A (en) | 2011-12-22 |
| US20110257129A1 (en) | 2011-10-20 |
| CA2664396A1 (en) | 2008-04-10 |
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