CO5690556A2 - Metodos y composiciones para la inhibicion de selectina - Google Patents
Metodos y composiciones para la inhibicion de selectinaInfo
- Publication number
- CO5690556A2 CO5690556A2 CO06045580A CO06045580A CO5690556A2 CO 5690556 A2 CO5690556 A2 CO 5690556A2 CO 06045580 A CO06045580 A CO 06045580A CO 06045580 A CO06045580 A CO 06045580A CO 5690556 A2 CO5690556 A2 CO 5690556A2
- Authority
- CO
- Colombia
- Prior art keywords
- aryl
- heterocycle
- arylalkyl
- alkyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- Un compuesto caracterizado porque tiene la Fórmula I: o una sal farmacéuticamente aceptable del mismo;donde:L es CO2H, un éster del mismo o un mimético de ácido farmacéuticamente aceptable;Y es O, (CR3R4)p ó NR5;p es 1 a 3;X es hidrógeno, OH, OR3, Oalquilo C1-6, OC(=O) arilo, OC(=O) alquilo C1-6, OC(=O)O alquilo C1-6 ó NR3R3AND#39;cada R1, R2, R3, R3AND#39, y R4 es independientemente hidrógeno, alquilo C1-6, perhaloalquilo C1-6, Oalquilo C1-6, Operhaloalquilo C1-6, halógeno, tioalquilo, CN, OH, SH, (CH2)nOSO3H, (CH2)nSO3H, (CH2)nCO2R6, OSO3R6, SO2R6, SO3R6, PO3R6R7, (CH2)nSO2NR8R9, (CH2)nC(=O)NR8R9, NR8R9, C(=O)R12, arilo, heterociclo, C(=O) arilo, C(=O) heterociclo, OC(=O) arilo, OC(=O) heterociclo, Oarilo, Oheterociclo, arilalquilo, C(=O), arilalquilo OC(=O) arilalquilo, Oarilalquilo, alquenilo, alquinilo o NHCOR8, donde cualquiera de alquilo, Oalquilo, arilo, heterociclo, C(=O)arilo, C(=O) heterociclo, O-C(=O) arilo, O-C(=O) heterociclo, O-arilo, O-heterociclo, arilalquilo, C(=O)arilalquilo, C(=O)arilalquilo, O-arilalquilo, alquenilo o alquinilo pueden sustituirse opcionalmente con hasta tres sustitutos iguales o diferentes seleccionados de halógeno, alquilo C1-6, Oalquilo C1-6 y CN;cada R6 y R7 es independientemente seleccionado del grupo que comprende hidrógeno y alquilo C1-6 opcionalmente sustituido con hasta tres sustitutos iguales o diferentes seleccionados de OH, CF3, SH y halógeno;cada R5, R8 y R9 se selecciona independientemente del grupo que comprende hidrógeno, alquilo C1-6, haloalquilo C1-6, tioalquilo, OH, (CH2)IOSO3H, (CH2)ISO3R10, (CH2)nCO2R10, SO3R10, PO3R10R11, (CH2)nSO2(CH2)nNR10R11, (CH2)nCONR10R11, COR10, arilo, heterociclo, C(=O) arilo, C(=O) heterociclo, O-C(=O)arilo, O-C(=O)heterociclo, Oarilo, Oheterociclo, arilalquilo, C(=O)arilalquilo, OC(=O) arilalquilo, Oarilalquilo, alquenilo o alquinilo, donde cada uno de alquilo, arilo, heterociclo, C(=O) arilo, C(=O) heterociclo, OC(=O) arilo, OC(=O) heterociclo, Oarilo, Oheterociclo, arilalquilo, C(=O) arilalquilo, OC(=O) arilalquilo, Oarilalquilo, ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51895003P | 2003-11-10 | 2003-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5690556A2 true CO5690556A2 (es) | 2006-10-31 |
Family
ID=34590327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO06045580A CO5690556A2 (es) | 2003-11-10 | 2006-05-12 | Metodos y composiciones para la inhibicion de selectina |
Country Status (21)
Country | Link |
---|---|
US (2) | US7465799B2 (es) |
EP (1) | EP1682511A2 (es) |
JP (1) | JP2007510742A (es) |
KR (1) | KR20060108666A (es) |
CN (1) | CN1902179A (es) |
AR (1) | AR046704A1 (es) |
AU (1) | AU2004288800A1 (es) |
BR (1) | BRPI0416357A (es) |
CA (1) | CA2544693A1 (es) |
CO (1) | CO5690556A2 (es) |
CR (1) | CR8384A (es) |
EC (1) | ECSP066558A (es) |
GT (1) | GT200400232A (es) |
IL (1) | IL175389A0 (es) |
NO (1) | NO20062348L (es) |
PA (1) | PA8617101A1 (es) |
PE (1) | PE20050579A1 (es) |
RU (1) | RU2006120450A (es) |
TW (1) | TW200526583A (es) |
WO (1) | WO2005047257A2 (es) |
ZA (1) | ZA200603683B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200522954A (en) * | 2003-11-10 | 2005-07-16 | Wyeth Corp | Methods and compositions for selectin inhibition |
US8686002B2 (en) * | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
WO2008043075A2 (en) * | 2006-10-05 | 2008-04-10 | Wyeth | Compositions for the treatment of scleritis |
MX2009010384A (es) * | 2007-03-30 | 2009-10-16 | Wyeth Corp | Derivados de quinolina y composiciones farmaceuticas que los comprenden para la inhibicion de selectinas. |
MX2009010514A (es) | 2007-03-30 | 2009-10-19 | Wyeth Corp | Metodos y composiciones para la inhibicion de selectina. |
EP2379076B1 (en) | 2008-12-23 | 2014-11-12 | The Trustees of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
US11946927B2 (en) | 2016-03-14 | 2024-04-02 | Musidora Biotechnology Llc | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
US10295527B2 (en) | 2016-03-14 | 2019-05-21 | Bruce Yacyshyn | Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
WO1999029705A2 (en) * | 1997-12-08 | 1999-06-17 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
AU2002345796A1 (en) * | 2001-06-26 | 2003-03-03 | Beth Israel Deaconess Medical Center | Compositions and methods for inhibiting platelet activation and thrombosis |
US7851701B2 (en) * | 2001-07-06 | 2010-12-14 | Nippon Kayaku Kabushiki Kaisha | Dye-sensitized photoelectric conversion device |
-
2004
- 2004-11-09 JP JP2006539741A patent/JP2007510742A/ja not_active Withdrawn
- 2004-11-09 AR ARP040104129A patent/AR046704A1/es unknown
- 2004-11-09 EP EP04818666A patent/EP1682511A2/en not_active Withdrawn
- 2004-11-09 KR KR1020067008995A patent/KR20060108666A/ko not_active Application Discontinuation
- 2004-11-09 CA CA002544693A patent/CA2544693A1/en not_active Abandoned
- 2004-11-09 WO PCT/US2004/037334 patent/WO2005047257A2/en active Application Filing
- 2004-11-09 US US10/984,093 patent/US7465799B2/en not_active Expired - Fee Related
- 2004-11-09 AU AU2004288800A patent/AU2004288800A1/en not_active Withdrawn
- 2004-11-09 CN CNA2004800397576A patent/CN1902179A/zh not_active Withdrawn
- 2004-11-09 PE PE2004001095A patent/PE20050579A1/es not_active Application Discontinuation
- 2004-11-09 TW TW093134111A patent/TW200526583A/zh unknown
- 2004-11-09 PA PA20048617101A patent/PA8617101A1/es unknown
- 2004-11-09 GT GT200400232A patent/GT200400232A/es unknown
- 2004-11-09 RU RU2006120450/04A patent/RU2006120450A/ru not_active Application Discontinuation
- 2004-11-09 BR BRPI0416357-5A patent/BRPI0416357A/pt not_active IP Right Cessation
-
2006
- 2006-05-02 IL IL175389A patent/IL175389A0/en unknown
- 2006-05-05 CR CR8384A patent/CR8384A/es not_active Application Discontinuation
- 2006-05-09 ZA ZA200603683A patent/ZA200603683B/en unknown
- 2006-05-10 EC EC2006006558A patent/ECSP066558A/es unknown
- 2006-05-12 CO CO06045580A patent/CO5690556A2/es not_active Application Discontinuation
- 2006-05-23 NO NO20062348A patent/NO20062348L/no not_active Application Discontinuation
-
2008
- 2008-11-11 US US12/268,681 patent/US20090076077A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2006120450A (ru) | 2007-12-27 |
CR8384A (es) | 2006-12-07 |
WO2005047257A2 (en) | 2005-05-26 |
NO20062348L (no) | 2006-08-01 |
AU2004288800A1 (en) | 2005-05-26 |
IL175389A0 (en) | 2006-09-05 |
CA2544693A1 (en) | 2005-05-26 |
JP2007510742A (ja) | 2007-04-26 |
ECSP066558A (es) | 2006-10-17 |
US7465799B2 (en) | 2008-12-16 |
CN1902179A (zh) | 2007-01-24 |
US20050101568A1 (en) | 2005-05-12 |
ZA200603683B (en) | 2008-05-28 |
KR20060108666A (ko) | 2006-10-18 |
PA8617101A1 (es) | 2006-09-22 |
EP1682511A2 (en) | 2006-07-26 |
BRPI0416357A (pt) | 2007-05-08 |
PE20050579A1 (es) | 2005-09-08 |
AR046704A1 (es) | 2005-12-21 |
TW200526583A (en) | 2005-08-16 |
US20090076077A1 (en) | 2009-03-19 |
GT200400232A (es) | 2005-09-14 |
WO2005047257A3 (en) | 2005-07-07 |
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