CO5290257A1 - Nuevos derivados de fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia - Google Patents

Nuevos derivados de fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia

Info

Publication number
CO5290257A1
CO5290257A1 CO01013432A CO01013432A CO5290257A1 CO 5290257 A1 CO5290257 A1 CO 5290257A1 CO 01013432 A CO01013432 A CO 01013432A CO 01013432 A CO01013432 A CO 01013432A CO 5290257 A1 CO5290257 A1 CO 5290257A1
Authority
CO
Colombia
Prior art keywords
alkyl
alkoxy
optionally substituted
phenyl
halogen
Prior art date
Application number
CO01013432A
Other languages
English (en)
Inventor
Tim Birkinshaw
David Cheshire
Antonio Mete
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5290257A1 publication Critical patent/CO5290257A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de la fórmula (I)<EMI FILE="01013432_1" ID="1" IMF=JPEG >En donde X y Y independientemente representan alquil C1 a 4, alcoxi C1 a 4, halógeno, CF3, OCF3, CN, C=CH, S(O)mCH3, S(O)pCF3, NO2 o NHCHO,m y p independientemente representan un entero 0, 1 o 2;Z representa H o fluoro;V representa O, S(O)n o NR3; W representa alquil C1 a 4, alquenil C2 a 4, alquinil C2 a 4, cicloalquil C3 a 6 o un anillo heterociclico saturado de 4 a 8 miembros que incorpora un heteroátomo seleccionado entre O, S y N; cualquiera de dichos grupos siendo además opcionalmente substituido por alquil C1 a 4, alcoxi C1 a 4, alquiltio C1 a 4, cicloalquil C3 a 6, halógeno o fenil; dicho grupo fenil siendo opcionalmente substituido además por uno o más substituyentes seleccionados independientemente entre halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2;o W representa fenil o un anillo heterocíclico aromático de cinco o seis miembros que contiene 1 a 3 heteroátomos independientemente seleccionados entre O, S y N; dicho fenil o anillo heterocíclico aromático siendo opcionalmente substituido por uno o más substituyentes seleccionados independientemente entre halógeno, alquil C1 a 4, alcoxi C1 a C4, OH, CN, NO2 o NR4R5; dicho grupo alquil o alcoxi siendo además opcionalmente substituido por uno o más átomos de flúor;R1 y R2 independientemente representan H, alquil C1 a 4 o cicloalquil C3 a 6; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, halógeno, hidroxi, NR6R7, fenil o un anillo heterocíclico saturado o aromático de cinco o seis miembros que contiene 1 a 3 heteroátomos independientemente seleccionados entre O, S y N; - 2 -dicho fenil o anillo heterocíclico aromático siendo además opcionalmente substituido por halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2;o el grupo NR1R2 junto representa un anillo azacíclico saturado de 4 a 8 miembros que incorpora opcionalmente un heteroátomo adicional seleccionado entre O, S o NR8; dicho anillo siendo opcionalmente substituido por alquil C1 a 4, alcoxi C1 a 4 o OH; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, OH o NR9R10; o el grupo NR1R2 junto representa parte de un anillo azacíclico aromático de cinco miembros que incorpora opcionalmente un átomo N adicional;R3 representa H o alquil C1 a 4;R4, R5, R6, R7, R9 y R10 independiente representan H o alquil C1 a 4;R8 representa H o alquil C1 a 6; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, OH, NR11R12, fenil o un anillo heterocíclico saturado o aromático de cinco a seis miembros que contiene 1 a 3 heteroátomos independientemente seleccionados entre O, S y N; dicho fenil o anillo heterocíclico aromático siendo además opcionalmente substituido por halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2; R11 y R12 independientemente representan H o alquil C1 a 4;n representa un entero 0, 1 o 2;o una sal, enantiómero o racemato del mismo farmacéuticamente aceptable.
CO01013432A 2000-02-23 2001-02-20 Nuevos derivados de fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia CO5290257A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0004149.1A GB0004149D0 (en) 2000-02-23 2000-02-23 Novel compounds

Publications (1)

Publication Number Publication Date
CO5290257A1 true CO5290257A1 (es) 2003-06-27

Family

ID=9886161

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01013432A CO5290257A1 (es) 2000-02-23 2001-02-20 Nuevos derivados de fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia

Country Status (10)

Country Link
US (1) US6743939B2 (es)
EP (1) EP1263714B1 (es)
JP (1) JP2003523992A (es)
AR (1) AR028220A1 (es)
AT (1) ATE265422T1 (es)
AU (1) AU2001234313A1 (es)
CO (1) CO5290257A1 (es)
DE (1) DE60103033T2 (es)
GB (1) GB0004149D0 (es)
WO (1) WO2001062713A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0004151D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004152D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
AR035700A1 (es) * 2001-05-08 2004-06-23 Astrazeneca Ab Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados
SE0102641D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0102640D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0202280D0 (sv) * 2002-07-19 2002-07-19 Astrazeneca Ab Novel compounds
SE0202279D0 (sv) * 2002-07-19 2002-07-19 Astrazeneca Ab Novel comppounds
SE0203304D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Coumpounds
EP2865381A1 (en) 2006-05-18 2015-04-29 Pharmacyclics, Inc. ITK inhibitors for treating blood cell malignancies
DE102006031813B4 (de) * 2006-07-07 2011-04-28 Christian-Albrechts-Universität Zu Kiel Verwendung basischer Acetophenone als Hemmstoffe von NO-Synthasen
JP6229896B2 (ja) 2013-01-21 2017-11-15 国立大学法人大阪大学 フェノキシアルキルアミン化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52941B1 (es) 1969-12-09 1977-01-11
JPS5144934B1 (es) 1969-12-09 1976-12-01
US4314081A (en) 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
FR2432500A1 (fr) 1978-02-24 1980-02-29 Roussel Uclaf Nouveaux derives de la benzene propanamine et leurs sels, procede de preparation et application a titre de medicaments
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
US4902710A (en) * 1988-12-14 1990-02-20 Eli Lilly And Company Serotonin and norepinephrine uptake inhibitors
US5320825A (en) 1991-05-01 1994-06-14 Trustees Of The University Of Pennsylvania Serotonin reuptake inhibitors for S.P.E.C.T. imaging
EP0576766A1 (en) 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
HN1998000118A (es) * 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
HN1998000125A (es) 1997-08-28 1999-02-09 Pfizer Prod Inc 2-aminopiridinas con sustituyentes alcoxi ramificados
DE69923448T2 (de) 1998-06-03 2005-12-29 Pfizer Products Inc., Groton 2-aminopyridine mit kondensierten ringsubstituenten als stickstoff-oxid-synthase inhibitoren

Also Published As

Publication number Publication date
DE60103033D1 (de) 2004-06-03
AU2001234313A1 (en) 2001-09-03
DE60103033T2 (de) 2005-04-28
US20030105161A1 (en) 2003-06-05
JP2003523992A (ja) 2003-08-12
ATE265422T1 (de) 2004-05-15
WO2001062713A1 (en) 2001-08-30
EP1263714B1 (en) 2004-04-28
GB0004149D0 (en) 2000-04-12
EP1263714A1 (en) 2002-12-11
US6743939B2 (en) 2004-06-01
AR028220A1 (es) 2003-04-30

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