CO5280089A1 - Antagonistas del receptor il-8 - Google Patents
Antagonistas del receptor il-8Info
- Publication number
- CO5280089A1 CO5280089A1 CO01020681A CO01020681A CO5280089A1 CO 5280089 A1 CO5280089 A1 CO 5280089A1 CO 01020681 A CO01020681 A CO 01020681A CO 01020681 A CO01020681 A CO 01020681A CO 5280089 A1 CO5280089 A1 CO 5280089A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- chloro
- optionally substituted
- aryl
- heterocycle
- Prior art date
Links
- 108090001007 Interleukin-8 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 25
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 229910052757 nitrogen Inorganic materials 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- -1 aryl- C1-4 alkyl Chemical group 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- GKPBKEGYKTZZSE-UHFFFAOYSA-N 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-(2,2,3,3-tetramethylcyclopropyl)urea Chemical compound CC1(C)C(C)(C)C1NC(=O)NC1=CC=C(Cl)C(S(N)(=O)=O)=C1O GKPBKEGYKTZZSE-UHFFFAOYSA-N 0.000 abstract 1
- CMRLUFNYQJTEFJ-UHFFFAOYSA-N 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-(2-methylcyclopropyl)urea Chemical compound CC1CC1NC(=O)NC1=CC=C(Cl)C(S(N)(=O)=O)=C1O CMRLUFNYQJTEFJ-UHFFFAOYSA-N 0.000 abstract 1
- ZTLMJQZASJPGLX-UHFFFAOYSA-N 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-(3-methoxycyclohexyl)urea Chemical compound C1C(OC)CCCC1NC(=O)NC1=CC=C(Cl)C(S(N)(=O)=O)=C1O ZTLMJQZASJPGLX-UHFFFAOYSA-N 0.000 abstract 1
- VAJDPANPZHGXTF-UHFFFAOYSA-N 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-(oxan-2-yl)urea Chemical compound NS(=O)(=O)C1=C(Cl)C=CC(NC(=O)NC2OCCCC2)=C1O VAJDPANPZHGXTF-UHFFFAOYSA-N 0.000 abstract 1
- VDFURVFRSNIHPU-RDJZCZTQSA-N 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-[(1s,2s)-2-phenylmethoxycyclohexyl]urea Chemical compound NS(=O)(=O)C1=C(Cl)C=CC(NC(=O)N[C@@H]2[C@H](CCCC2)OCC=2C=CC=CC=2)=C1O VDFURVFRSNIHPU-RDJZCZTQSA-N 0.000 abstract 1
- FXCSFWFPSKYJDE-UHFFFAOYSA-N 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-cyclohexylurea Chemical compound NS(=O)(=O)C1=C(Cl)C=CC(NC(=O)NC2CCCCC2)=C1O FXCSFWFPSKYJDE-UHFFFAOYSA-N 0.000 abstract 1
- BJRTUULSRWFVBT-UHFFFAOYSA-N 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-piperidin-4-ylurea Chemical compound NS(=O)(=O)C1=C(Cl)C=CC(NC(=O)NC2CCNCC2)=C1O BJRTUULSRWFVBT-UHFFFAOYSA-N 0.000 abstract 1
- KGAGRXQEAHQPHP-UHFFFAOYSA-N 4-[6-chloro-3-(cyclopentylcarbamoylamino)-2-hydroxyphenyl]sulfonylpiperazine-1-carboxylic acid Chemical compound C1CN(C(=O)O)CCN1S(=O)(=O)C1=C(Cl)C=CC(NC(=O)NC2CCCC2)=C1O KGAGRXQEAHQPHP-UHFFFAOYSA-N 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910003813 NRa Inorganic materials 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
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- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
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- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18984800P | 2000-03-16 | 2000-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5280089A1 true CO5280089A1 (es) | 2003-05-30 |
Family
ID=22699008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO01020681A CO5280089A1 (es) | 2000-03-16 | 2001-03-14 | Antagonistas del receptor il-8 |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1263427A4 (cs) |
| JP (1) | JP2003526664A (cs) |
| KR (1) | KR20020091130A (cs) |
| CN (1) | CN1424910A (cs) |
| AP (1) | AP2002002606A0 (cs) |
| AR (1) | AR031098A1 (cs) |
| AU (1) | AU2001250873A1 (cs) |
| BG (1) | BG107013A (cs) |
| BR (1) | BR0108749A (cs) |
| CA (1) | CA2403062A1 (cs) |
| CO (1) | CO5280089A1 (cs) |
| CZ (1) | CZ20023075A3 (cs) |
| DZ (1) | DZ3317A1 (cs) |
| EA (1) | EA200200981A1 (cs) |
| HU (1) | HUP0300470A3 (cs) |
| MA (1) | MA25659A1 (cs) |
| MX (1) | MXPA02009094A (cs) |
| NO (1) | NO20024367L (cs) |
| OA (1) | OA12231A (cs) |
| PL (1) | PL366034A1 (cs) |
| SK (1) | SK13282002A3 (cs) |
| WO (1) | WO2001068084A1 (cs) |
| ZA (1) | ZA200207325B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR030689A1 (es) * | 2000-03-14 | 2003-09-03 | Smithkline Beecham Corp | Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas |
| EP1745032B1 (en) | 2004-05-12 | 2013-07-31 | Merck Sharp & Dohme Corp. | CXCR1 and CXCR2 chemokine antagonists |
| JP2009534420A (ja) * | 2006-04-21 | 2009-09-24 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体アンタゴニスト |
| JP5269763B2 (ja) * | 2006-04-21 | 2013-08-21 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｉｌ−８受容体アンタゴニスト |
| CR20160557A (es) * | 2014-05-29 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2 |
| CN106660950A (zh) * | 2014-07-31 | 2017-05-10 | 葛兰素史密斯克莱知识产权发展有限公司 | Cxcr2拮抗剂用于预防和/或治疗化疗诱导的周围神经病变(cipn)的用途 |
| WO2019137484A1 (zh) * | 2018-01-11 | 2019-07-18 | 南京明德新药研发股份有限公司 | Cxcr2拮抗剂 |
| EP3998256A4 (en) * | 2019-07-11 | 2023-07-19 | Shenzhen Optimum Biological Technology Co., Ltd | CRYSTALLINE FORM OF CXCR2 ANTAGONIST AND ITS USE |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996025157A1 (en) * | 1995-02-17 | 1996-08-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| WO1997049680A1 (en) * | 1996-06-27 | 1997-12-31 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| US6214881B1 (en) * | 1996-08-21 | 2001-04-10 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| SK284757B6 (sk) * | 1998-09-23 | 2005-11-03 | Tularik Inc. | Arylsulfónanilidmočoviny, farmaceutický prostriedok s ich obsahom a ich použitie |
| UY25842A1 (es) * | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
-
2001
- 2001-03-14 AR ARP010101183A patent/AR031098A1/es unknown
- 2001-03-14 CO CO01020681A patent/CO5280089A1/es not_active Application Discontinuation
- 2001-03-16 CA CA002403062A patent/CA2403062A1/en not_active Abandoned
- 2001-03-16 SK SK1328-2002A patent/SK13282002A3/sk unknown
- 2001-03-16 CZ CZ20023075A patent/CZ20023075A3/cs unknown
- 2001-03-16 WO PCT/US2001/008672 patent/WO2001068084A1/en not_active Ceased
- 2001-03-16 EP EP01924195A patent/EP1263427A4/en not_active Withdrawn
- 2001-03-16 DZ DZ013317A patent/DZ3317A1/fr active
- 2001-03-16 KR KR1020027012102A patent/KR20020091130A/ko not_active Withdrawn
- 2001-03-16 AU AU2001250873A patent/AU2001250873A1/en not_active Abandoned
- 2001-03-16 HU HU0300470A patent/HUP0300470A3/hu unknown
- 2001-03-16 MX MXPA02009094A patent/MXPA02009094A/es active IP Right Grant
- 2001-03-16 CN CN01806605A patent/CN1424910A/zh active Pending
- 2001-03-16 OA OA1200200289A patent/OA12231A/en unknown
- 2001-03-16 AP APAP/P/2002/002606A patent/AP2002002606A0/en unknown
- 2001-03-16 JP JP2001566648A patent/JP2003526664A/ja not_active Withdrawn
- 2001-03-16 EA EA200200981A patent/EA200200981A1/ru unknown
- 2001-03-16 PL PL01366034A patent/PL366034A1/xx not_active Application Discontinuation
- 2001-03-16 BR BR0108749-5A patent/BR0108749A/pt not_active Application Discontinuation
-
2002
- 2002-08-20 BG BG107013A patent/BG107013A/bg unknown
- 2002-09-12 ZA ZA200207325A patent/ZA200207325B/en unknown
- 2002-09-12 MA MA26815A patent/MA25659A1/fr unknown
- 2002-09-12 NO NO20024367A patent/NO20024367L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1263427A4 (en) | 2005-08-24 |
| WO2001068084A1 (en) | 2001-09-20 |
| BR0108749A (pt) | 2004-06-29 |
| SK13282002A3 (sk) | 2003-02-04 |
| HUP0300470A3 (en) | 2005-05-30 |
| MA25659A1 (fr) | 2002-12-31 |
| AR031098A1 (es) | 2003-09-10 |
| AP2002002606A0 (en) | 2002-09-30 |
| NO20024367L (no) | 2002-10-22 |
| BG107013A (bg) | 2003-05-30 |
| EA200200981A1 (ru) | 2003-02-27 |
| NO20024367D0 (no) | 2002-09-12 |
| AU2001250873A1 (en) | 2001-09-24 |
| CA2403062A1 (en) | 2001-09-20 |
| ZA200207325B (en) | 2003-10-17 |
| PL366034A1 (en) | 2005-01-24 |
| KR20020091130A (ko) | 2002-12-05 |
| MXPA02009094A (es) | 2003-03-12 |
| JP2003526664A (ja) | 2003-09-09 |
| OA12231A (en) | 2003-11-07 |
| DZ3317A1 (cs) | 2001-09-20 |
| HUP0300470A2 (hu) | 2003-06-28 |
| CZ20023075A3 (cs) | 2003-05-14 |
| CN1424910A (zh) | 2003-06-18 |
| EP1263427A1 (en) | 2002-12-11 |
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Legal Events
| Date | Code | Title | Description |
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| FA | Application withdrawn |